DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and exc-5

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001294029.1	Gene:	exc-5 / 177692	WormBaseID:	WBGene00001366	Length:	861	Species:	Caenorhabditis elegans

Alignment Length:	902	Identity:	186/902 - (20%)
Similarity:	337/902 - (37%)	Gaps:	226/902 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 TKRRPPMLSRSNSGSSRRSMQMN----SRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEF------ 1165
            |.|.||...:.:.....:|.:.|    |...|:.:..|.:|... |:.:..|..:|..|
Worm     3 TGRPPPFFKQMHYPHGPQSNEWNDFVPSFLAPKMSSLVQLPSQP-SSAFQLDFDAVRNFQNVPPV 66

  Fly  1166 ------LASACARRNLNPMEH-FVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQ 1223
                  |..|.....::|::. .|||...|                  .|...|..|:...:..:
Worm    67 DLEGGTLIDATEEEEIDPVDGCTVRVFTYR------------------ILSADEMEELTKTVRQK 113

  Fly  1224 VELQRT-TLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKG-DEIMVINGA--I 1284
            ::...| |:..:.....||.::|.::|                  .:|.||| ..|...|.:  |
Worm   114 IKFDCTQTMRSLKMIGSEANVVEKSQR------------------ISGDIKGMKPIEFSNNSKQI 160

  Fly  1285 VSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMIT 1349
            ..|...:.|:...:::|.:|.::..   .|...:.::....||...|.        |.:.|:|.|
Worm   161 CLDQHSLQLDPNDEQDQQISRVLNQ---VPNTFMSLLSREKDMFVKLY--------PELFEKMRT 214

  Fly  1350 -GLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLA-----VGGV--------------- 1393
             ..::|:.    |::.:.:|  :.|..|......:.::..:     |.||
Worm   215 ESSLIPST----TTEIITNP--DGSTTTRVKSSKSYSSHFSRQETYVNGVKKMSKSKFRAFVEYK 273

  Fly  1394 ---GGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSV-STTALTPSRQLTDAE 1454
               ||..|       ..|....||    |...|||...:|.:.|..|.: |.:.:|.....||.:
Worm   274 GPDGGFQV-------KLSDGDEFE----LSEDEQEDDDTSLSQSCYSEIDSESDITGPSPKTDLD 327

  Fly  1455 KLRK----VVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQR-QFL 1514
            |..:    ...||||:|:.||..|..|.:.:...:.:|..::|.:|..|..|:..:..|.. .||
Worm   328 KRYQKAWYAAKELVDSEQRYVDKLKLLGDTFRNRLIKEELITNDKITRLLANVSSLYQFHNTHFL 392

  Fly  1515 QNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHA 1579
            ..|.||:      ..:....:..||: ...:.||      |:||.:..::.:|.|:....:....
Worm   393 PQLLESI------RDWHTTKRIANVV-RKQAPFL------KMYSEYTNNYDRATKLFEELKKKKK 444

  Fly  1580 LQEFLAARNPKQQ-HSSTLESYLIKPIQRILKYPLLLQQMR--------NLTDTRADEHVHLCEA 1635
            ..:.:.....:.: ....|..:||.|:||:::|.||||:.:        :..||..        |
Worm   445 FADVVKEIEKQAECEGLPLGHHLICPVQRVMRYQLLLQEYKKHLQPSDVDFDDTTV--------A 501

  Fly  1636 LKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDL-SPG-DLLYYGGVEWLNISDFLG 1698
            |:.:.:.|.|.|||.:..:.:|.:.     :.|:.....|.| ||| :||..|.|:  .||....
Worm   502 LELVLQAAAHANEMMKKLDRFGKVI-----EVQEQLGNSISLVSPGRELLKSGSVQ--KISSTTE 559

  Fly  1699 KIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASS 1763
            |.::     ...|:|...|:      |..::|::|||.         .:.:.:...:.:||....
Worm   560 KTEE-----RFIFLFNDLVI------LASERKMIGVSK---------YKLRAVFSASHMQVCEGD 604

  Fly  1764 AKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGS 1828
            ..:.:..|     :||.......::...|...|...:|.::.:|..||.|: :..|:...:  .|
Worm   605 NLEREHSF-----YLRGSDGTGPKRCVELFTPTQKEKNDWVDSIFSIIDEA-KAHSLTFTS--SS 661

  Fly  1829 SGSVSGHSSQGMGS---------MGYPGNSQTLERPKQQITIVHGSHTLGKP---KKKSGSQRH- 1880
            ..|:|.:::..:.|         .|:      |.|..:   .|..|..|.|.   ::::.|::|
Worm   662 RSSISENNNNSIESKHCADCDIEFGF------LSRGSK---CVKCSRRLCKKCFGRRRNESKKHR 717

  Fly  1881 ----SAGNIDYDNL--SGSQEAD------DLPPSVGVVHYASGHTHGQQMQPAGFRG 1925
                ...|:|.|.:  |.|.:::      .||..      .||..|..|::   |||
Worm   718 ICDTCTKNMDLDGIPRSFSTQSNMRRNLLQLPAK------GSGVLHSSQIR---FRG 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	16/90 (18%)
		PDZ_signaling	1221..1308	CDD:238492	17/90 (19%)
		RhoGEF	1456..1647	CDD:238091	46/204 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	35/174 (20%)
		PH	1693..1812	CDD:278594	21/118 (18%)
exc-5	NP_001294029.1	RhoGEF	336..514	CDD:279015	46/198 (23%)
		PH	545..647	CDD:278594	24/128 (19%)
		PH1_FGD1-4_like	545..643	CDD:275423	23/124 (19%)
		FYVE	676..727	CDD:214499	10/59 (17%)
		PH-like	<773..845	CDD:302622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910