DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and tag-77

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001294044.2	Gene:	tag-77 / 177656	WormBaseID:	WBGene00006450	Length:	1029	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	85/445 - (19%)
Similarity:	154/445 - (34%)	Gaps:	114/445 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1887 YDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQ 1951
            || ::..:.:||.||:                        |:||                 ::..
Worm     3 YD-MNHRKNSDDTPPA------------------------SRTV-----------------KEMM 25

  Fly  1952 QQQQQLMQQG--HAHAHPHPHPHPRE-PPPPPIRQP-HLHHHSSDIERIDPGTKSEGEE------ 2006
            .:.|..:..|  .....|.|.|.||. |||||.|:| .|.....|...|.|.:.||..|
Worm    26 AEFQNKLDDGDNRFRKQPPPPPSPRRAPPPPPHRKPASLSPPPDDENTIRPPSSSESSENIPEEP 90

  Fly  2007 ------DSQQGTIRPKATLGRTPNHLT--LSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDL 2063
                  ::.:.::.||.|:...|..|.  |.::||..|.|..|..   ...||..:...:|:
Worm    91 QELITPNTTRRSLGPKPTVAPKPLFLNGLLPSSSTSDVSSQNSPK---CDPHPSCTTPTILV--- 149

  Fly  2064 GKPSPDESELESESEVHAAQVAASFNLSLGSSGSLF-ASDARDNQTQSRTQSQIH-SLHPSPRQS 2126
               ||..||.                    |:|..| |::...:..:.|.:..:: ...|..:..
Worm   150 ---SPATSEY--------------------SNGVFFGANETNGSGVKDRARQLVNMGFVPRMQNG 191

  Fly  2127 PRQSPRQSPKQDIEVIEIFESEAER--LAASQQVAVVHQHPSDQARESGHKQRRDRD-----RNP 2184
            ...:|.:.|...:..:.....|.:.  .:||.:.::     :.:.....|:...|.|     :|.
Worm   192 GTGTPSERPISQVSTLSQVSDEFDEGDTSASDEESM-----NSEKHLRRHRHEDDFDELPLPKNE 251

  Fly  2185 TETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFD--PQDLAE--DTGDHQQNDSSLS 2245
            .:|...|....:.::::|...:..|..:...:.:..|:...|  |.|:.:  |....:.|...:|
Worm   252 RKTTTVAATHSEIMNEMEHLFVRGGKKNNGVHKQQRRQSNIDEIPSDVGKLRDNRKGRHNSLFVS 316

  Fly  2246 PEPQTIVENTQQ-----TVVVDIES--PSRPATESDSTGNTTGPSERSGDETEEE 2293
            |.......:|..     ::..|..|  .|....|..:.|.:..|...:|||.:::
Worm   317 PTSGMSSSSTDDFSRITSMTSDRSSILTSHSGGEDSTDGASPVPDYETGDEKDDQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
tag-77	NP_001294044.2	RhoGEF	376..570	CDD:238091
		PH1_FGD5_FGD6	588..712	CDD:275424
		FYVE	793..860	CDD:214499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910