DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and osg-1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_498172.3 Gene:osg-1 / 175756 WormBaseID:WBGene00019832 Length:1182 Species:Caenorhabditis elegans


Alignment Length:1413 Identity:280/1413 - (19%)
Similarity:458/1413 - (32%) Gaps:494/1413 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1060 LPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSG 1124
            :|.||...| ||..|:|           ||:. ...||.:.||.........:||..|:..|...
 Worm    22 VPRPKRSAT-VSPSTRN-----------SFYN-SRRRSDANLNFFNERERQRERRRSMVRASRER 73

  Fly  1125 S-SRRSMQMNSR---DEPEKTFKVAMPD---NAYSTVYLRDAMSVEEFLASACARRNLNPMEHFV 1182
            | |||:.|.|.|   .||    .|.||.   .|...:.|    |:.:|::   |.||        
 Worm    74 SESRRASQQNLRKTNSEP----NVDMPSIDVEALQKLLL----SIPKFVS---ASRN-------- 119

  Fly  1183 RVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKIL-YQVELQRTTLEQMWGFSVEAELIEN 1246
            |:.:|.|.:........    ||......:.::...::| |..:    |.....|....|:.:|:
 Worm   120 RINQRHDSDSGGEMTTE----IEELKDAAKSIQSLQRVLAYPSQ----TSSDRGGNRRLADPVES 176

  Fly  1247 AERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLD-----MMYLESVLQEEQSLSMM 1306
            .....    ..|.|::.|:|.       |.|......|.:.|.     |.::.|:..::...:..
 Worm   177 CLESS----VFSDVDESSLAT-------DTIEGRRSGISTRLGHPRGVMQFIPSIRNDQFVPTSE 230

  Fly  1307 MR----SSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMS------EEMI---TGLIVPAP-- 1356
            :|    |.::..||  |.|  |.:|....|       |.|.:      :||.   |.|:|..|  
 Worm   231 IRRNSISRKSSVPD--GFM--TSEMESEPV-------PNVRNRRRGIVDEMFSSSTSLLVDRPSE 284

  Fly  1357 ---GWNGTSK--DLY-----SPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTS 1411
               |.|..:|  |.:     ||  |..|:.|: :|       .|...||..:...|         
 Worm   285 TLAGVNRFAKLLDTFRSRPTSP--EQHPSISW-NP-------YVYSDGGEALETCG--------- 330

  Fly  1412 SFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNN 1476
               :|:.|..|:....|.....|:....|...|              ...||:|||:::|:.|..
 Worm   331 ---MEDSLHEADILLWKKRSRASLRRHYSVRHL--------------AARELLDTEKSFVEGLEF 378

  Fly  1477 LLEHYLEPMKRE---TFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRN 1538
            |:..|:.|:::.   |.:..:.::.:|..|.||:...:..|..|.:.:|   .::|....|   :
 Worm   379 LVTKYMRPLRQPLECTLIEASLVDKIFYRIPEILAHHQVLLTTLSQRID---QWHKDAILG---D 437

  Fly  1539 VLFAIGS------AFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTL 1597
            ||.|..|      .::.:|::||...   ||..:|::       .||.:::.........:...|
 Worm   438 VLLAHFSKQSMIETYISFVDNFKFAK---ASIIQARQ-------KHAFEKYYNRCCRDHPNKLDL 492

  Fly  1598 ESYLIKPIQRILKYPLLLQQMRNLTDT---------RADEHVHLCEAL------KGMEKVAEHIN 1647
            :|.||.||||:.:|.|:::||...|..         ||..|:| |.|:      .|.|::.:.:.
 Worm   493 DSLLISPIQRVPRYELIVKQMLKHTPVEHEDRERLLRAQRHIH-CLAVAINQHKDGSEQMEQRLR 556

  Fly  1648 EMQRIHEEYGAIF--DHLFRQHQKSCKQPIDLSPGDLLYYGGVE----WLNISDFL--GKIKKG- 1703
            |::.|.:....:.  |....:|             |::...|.:    ...:||.|  ..:||. 
 Worm   557 EIEAIVDGLDDLVTKDRTLLRH-------------DIITLKGTDRERCIFMLSDLLLVTSVKKKP 608

  Fly  1704 --------------LELHAMCFVFKSAV--VFLCKERLRQ------------------KK----- 1729
                          ||.:....:||.|:  |.:.|:.|.|                  ||     
 Worm   609 KVLYSKMSSQSMGFLEGNRFKLLFKVALEDVQISKDTLSQLEEVERKLESSREDDRVLKKMSQLC 673

  Fly  1730 KLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSN 1794
            .|:....|.....:|.:.....:.:.|:..:.||..|:.:      :|| ..|.....:.:||..
 Worm   674 SLLKCERKVLMEMLETMETSNSMSIRELNEQMSSDPDLSA------VHL-DVLTSNGFEPFVLEF 731

  Fly  1795 STADFRNAFLKTIRQIIRESVRNM----SIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERP 1855
            ..|:.|:.|....:.......:|:    |..:|       ::..|.:                ||
 Worm   732 PNAEKRSVFEAMFKDAKATLAKNLLAAPSCSLK-------TIIAHQT----------------RP 773

  Fly  1856 KQQI---TIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQ 1917
            ..|:   |:|.|...                              |..||:.|.  ||....||.
 Worm   774 GLQLCTATVVPGKRV------------------------------DSTPSLWVC--ASDKFSGQV 806

  Fly  1918 MQPAGFRGRSKTVGDVTEITCSS------------PEPHQQQQQQQQQQQQLMQQGHAHAHPHPH 1970
            ...|      ...|::|..:||:            |.|.:.::::.:.|:.|             
 Worm   807 AVMA------LDTGEITIESCSAIGNAAVTAMCTVPPPMKLRKRKIKSQKSL------------- 852

  Fly  1971 PHPREPPPPPIRQPHL--------HHHSSDIE-RIDPGTKSEGE-------EDSQQGTI------ 2013
                         .||        :...||.| ..|.||.:.|:       :|.:...:      
 Worm   853 -------------EHLLNETIMDINSSGSDTESSSDEGTSTAGQTTVWIGNDDGEVFVVNSTERV 904

  Fly  2014 --RPKATLGRTPNHLT---LSTTSTLSVGSTGSQARLI----------------QSSH----PPA 2053
              |.:..|.|..|.:|   .:..:.|...|..:|.:|:                ...|    |..
 Worm   905 RSRARDRLARLRNSITSICAANGNVLVATSYSNQVQLLLFRPASDGSWDLENPQTVGHVCQAPIT 969

  Fly  2054 SYQPV--------------LMKDLGK--------PSPDESEL------------ESESEVHAAQV 2084
            |.|.:              ...|.||        ||.|...|            ...:||....|
 Worm   970 SMQLIGRRVIIASGNWLHAYFVDTGKFQPPVEILPSSDVITLMYVTGQNVFLCGRKSTEVFVVDV 1034

  Fly  2085 AASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPR--------------------- 2128
               ||||:.:..::.:.      .:|:...:.|.|........|                     
 Worm  1035 ---FNLSIINHFNVVSF------VRSQLSGREHILREHKMGCLRISCLTVARSHLWIGTSAGCVL 1090

  Fly  2129 ----QSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDA 2189
                ||.|..|..|:.|.||..|...|:...........|||       .||:|.....|.:..:
 Worm  1091 STSVQSARSQPTPDLRVCEIGHSGPCRILLPVHTPSHSNHPS-------RKQKRSSLNVPAQQSS 1148

  Fly  2190 TARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDH 2237
            ....:..      .|.|.|||.               .||.:.|..:|
 Worm  1149 QLMLVSC------GEGLDDGTA---------------TQDPSTDAINH 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413 15/80 (19%)
PDZ_signaling 1221..1308 CDD:238492 16/92 (17%)
RhoGEF 1456..1647 CDD:238091 53/214 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/224 (17%)
PH 1693..1812 CDD:278594 31/160 (19%)
osg-1NP_498172.3 RhoGEF 361..543 CDD:214619 51/198 (26%)
PH-like 524..>612 CDD:302622 19/101 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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