DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and ect-2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_496318.1	Gene:	ect-2 / 174658	WormBaseID:	WBGene00002297	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	1029	Identity:	181/1029 - (17%)
Similarity:	346/1029 - (33%)	Gaps:	319/1029 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1130 MQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHN 1194
            |.::....|:|..| .:...|.|...:.|...:.|.|.....:||:|.:::........|..::.
Worm     1 MDVSMLQSPQKRIK-TIQKLAVSKKDVHDFKDIFEMLEEQKEKRNINIIQYDSLDDLSGDWSEYT 64

  Fly  1195 YFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSR 1259
            :|..:.:..:...|..|:..:....|               |.||
Worm    65 FFCGNFDSDLFRTLTKHQETQALFII---------------GASV-------------------- 94

  Fly  1260 VEDKSVAMHNGIIKGDEIMVINGA------IVSDLDMMYLESVLQEEQSLSMM------MRS--- 1309
                   :.|.::|.:::|.:..|      ::.|:.|.....|..:.:.:.::      :|.
Worm    95 -------LKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAAEVPNKRELVDLVHYMGGSVRKDTV 152

  Fly  1310 SRT------------EPPDLVGIMRVTDDMI--------DSLVCPPPP----------------- 1337
            |||            :...|||:..:..|.:        ||......|
Worm   153 SRTNVFIAAKVEAKVQSISLVGVPTMRADWVTECWKHRDDSYFDVMEPCFVDKHRLGVFEGLSLF 217

  Fly  1338 --------TDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLA----- 1389
                    .|..:.|.|...|.:.|:|  ...:..:|:|:.:.      |:..|:::...
Worm   218 FHGFKQTEIDDMLRSLENTGGKLAPSP--TLATHVVYNPDNDE------VETLAVSSNQVHVTKE 274

  Fly  1390 ---VGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLT 1451
               |....|........|.||.:.....:|:        :..|||.|....|.::.:|:..|..:
Worm   275 WFWVSLHRGCCAIEDNFALPTGKLHRKPLES--------SSVSSPIGKSLRSQNSRSLSSMRDCS 331

  Fly  1452 ------------------DAE----------KLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRE 1488
                              |.|          |..:|.||:|:||:.|:. |..|:..:.|.::.|
Worm   332 VEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLS-LLKLVVKFKEALECE 395

  Fly  1489 ----TFLSNAEINALFG------NIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFA- 1542
                .|:|.:::..:||      .:||.:..:...:.|...:|....:..|.:.    :|:.||
Worm   396 ISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANTLLTVVNGKKNDD----KNLDFAQ 456

  Fly  1543 --------IGSAFLYYVNHF----KLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSS 1595
                    :..|:..|:|.:    :|:......:||........|.|   .||         |..
Worm   457 VWIDAKEEMKKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKESN---PEF---------HRL 509

  Fly  1596 TLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIF 1660
            .|...::||:||:....|||::|...:|::...:..  ||.|.:::|.:..|:.:..::.:   .
Worm   510 KLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKNNAE--EAAKAIDEVLKTANKTREKNDNF---I 569

  Fly  1661 DHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHA--MCFVFKSAVVFLCKE 1723
            .||.:........||.::...:.    :..|.:|. :.....||:..|  ..|:|...::.   .
Worm   570 SHLSKFTDIENVPPILVAANRMF----IRELVVSP-IASTSPGLQQFAKMKLFLFHDVLII---T 626

  Fly  1724 RLRQKKKLMGVSSKNAT---------------NEVEI----IRYQVLIP-----VTEVQVRASSA 1764
            ::|.:|..|...:::|:               :::::    ..:::..|     ..|:|.:..|.
Worm   627 KIRSEKNTMQRLARHASFASLHSRQRRPYRYIDQIQLNTMRSAFRIRAPDEIAKCLELQQQNGST 691

  Fly  1765 KDMDSHFLWELIH-------------------LRSQLQRRSEKV------YVLSNSTADFRNAFL 1804
            |  .:.|:|.|||                   :|..|.....|:      :..|:..:|......
Worm   692 K--PNVFVWCLIHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKILSDCGRFFYSSDPSDMNEIND 754

  Fly  1805 KTIRQIIRESVRNMSIPMKNFGGSSG---SVSGHSSQGMGS-----MGYPGNSQTLER--PKQQI 1859
            ..:..:.....||:......:|..|.   :||..|:|...|     |..|.:...:.|  ...|:
Worm   755 AMVSDMTTRYFRNLCGAKPQYGHGSQMNITVSERSTQNEWSHNESFMPPPQSQSRMRRAFSNAQL 819

  Fly  1860 TIVHGSHTLGKPKKKSGSQRHSAGNIDYD-----------------------NLSGSQEADDLPP 1901
            |:   :.|||..:.:|   |::.|.|:.:                       .|.|.|...:..|
Worm   820 TL---ATTLGFGRNQS---RNNLGQINENTTFLQSPRVSCDPAALANMTSVGGLPGCQSESESTP 878

  Fly  1902 SVGV------------VHYASGHTHGQQMQPAGFR------GRSKTVG-DVTEI 1936
            ..|:            .|...|.....:.|..||.      .||||.. .||:|
Worm   879 KRGIRSRLTSTTFLGGRHNILGRNTSMRRQATGFAHSEKELPRSKTSSYRVTDI 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	13/77 (17%)
		PDZ_signaling	1221..1308	CDD:238492	10/98 (10%)
		RhoGEF	1456..1647	CDD:238091	48/213 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	32/223 (14%)
		PH	1693..1812	CDD:278594	25/169 (15%)
ect-2	NP_496318.1	BRCT	131..188	CDD:237994	8/56 (14%)
		BRCT	209..280	CDD:214602	11/78 (14%)
		RhoGEF	367..560	CDD:279015	48/211 (23%)
		PH-like	551..729	CDD:302622	29/190 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910