DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and rhgf-2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001368191.1 Gene:rhgf-2 / 173748 WormBaseID:WBGene00006476 Length:1149 Species:Caenorhabditis elegans


Alignment Length:1243 Identity:240/1243 - (19%)
Similarity:430/1243 - (34%) Gaps:347/1243 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1046 FRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGA 1110
            ||..|........|||         :.||.:|         ||...|:              ...
 Worm    70 FRESCSTIGSPLDELP---------ALPTSST---------SSPFKFM--------------ESI 102

  Fly  1111 TKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMP------DNAYSTV-YLRDAM-SVEEFLA 1167
            .::|..|..|:.|.|:     :.:.::...|.:.::|      |...|:| :.|... |:.....
 Worm   103 QRKRKSMFRRNQSSSN-----LINTEKRRTTRRPSLPSIPPTIDEMSSSVGHARSRRPSLHNDWT 162

  Fly  1168 SACARRN-LNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEV-CMKILYQV-----E 1225
            :..|:|| |:...|.:.:    |....|||:....||.:....:.|.:.. |.:::|:|     .
 Worm   163 NEHAQRNALDNRIHHIDI----DPPQINYFIAVFKDLDDREKDSVEHIRFDCNQLIYEVFEPFLR 223

  Fly  1226 LQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLD- 1289
            ::..|:..: .|.:|.......|..........|:..:.        :|:..:|.:......:| 
 Worm   224 IRGLTINDV-EFFLEKSSTPIPENSGARFLAGQRIFVRG--------RGNMKVVRHTRATHSMDE 279

  Fly  1290 -------MMYLESVLQEEQSLS--MMMRSSRTEPPDLVGI-------MRVTDDMI---DSLVCPP 1335
                   .|..|:|.::...::  ::.|.||..|    |:       .|..|..:   ||.    
 Worm   280 SNERATRKMSAEAVSRKSSFVNSRILNRGSRNHP----GLNGSDDAECRSNDSSLSVRDSW---- 336

  Fly  1336 PPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGG 1400
             ..|.|..||       ||..|  ||.:   :....||..:.|                      
 Worm   337 -QYDEPSCSE-------VPDDG--GTRR---ARSVTSSRISLF---------------------- 366

  Fly  1401 LGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVT----------SSVSTTALTPSRQLTDAEK 1455
              ..|.|.:... |:..:|...:::|....||..:.          .|:|..::          |
 Worm   367 --FGKETGKIEK-EMFRILNQKKEDTDLEYPTYKLEKDWREIVHNHESLSDKSI----------K 418

  Fly  1456 LRKVVMELVDTERTYVKHLNNL--LEHYLEPMKRETFLSNAEINALFGNIHEI--VTFQRQFLQN 1516
            .::.:.|:|.||..|:|.|..|  |..||..::...||.:.|...:|.|...:  |.:...:||:
 Worm   419 QQEAIWEIVTTEFRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQS 483

  Fly  1517 LEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKA----QKVLHPNEGN 1577
                  :||...|....|:..:|.: :.:.|....|..:.|::|..:||.:    ||.|..:|. 
 Worm   484 ------IEPILAKSRETGEPLDVNY-LQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESEN- 540

  Fly  1578 HALQEFL----AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKG 1638
              .::|:    |..|..:|  ..::::.: |:||:.:|.|||:.:..:| |..:|...:...:..
 Worm   541 --FRDFVTWAEAQENLDRQ--KLIDTFSV-PMQRLTRYNLLLKAVLKVT-TDENEREMISNLVDC 599

  Fly  1639 MEKVAEHINEMQRIHEEYGAIFDHLFR-------------QHQKSCKQPIDLSPGD--------- 1681
            .|.....:|: :..:.:..|:...:.|             :...:.|.|::|  ||         
 Worm   600 AESATAQLNK-ELNNNDLRAMLGDVMRTIEGPDYVDQDELERLFNLKLPLNL--GDFMPLLHPRK 661

  Fly  1682 -----LLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATN 1741
                 |:|.|.:.       :.:.|||.:....|.:|..  :||...:::.||.           
 Worm   662 PTHRTLIYRGDLR-------MQEGKKGSKADVHCIIFTD--MFLICRKVQGKKD----------- 706

  Fly  1742 EVEIIRYQVLIPVTEVQVRASSAKDMDSHFL----WELIHLRSQLQRRSEKVYVLSNS------- 1795
                 |.::|.|...:      .|.|..:|.    :.|:||..  ...::.:|.:..|       
 Worm   707 -----RLKILKPPIHM------GKMMFHYFADQNGFYLVHLTD--FHTAQALYSMHTSGPEDTLR 758

  Fly  1796 TADFRNAFLKTIRQIIRES---VRNMSIPMKNFG-GSSGSVSGHSSQGMGSMGYPGNSQTLERPK 1856
            ..|.....|...::|.|:|   ......|:..:| |.....|...||.|...||         .:
 Worm   759 WTDMLKMALDEFKKIHRDSWSQQNQQESPLDEYGRGFIMEPSSFYSQRMLPPGY---------AQ 814

  Fly  1857 QQITIVH-----------GSHT--------------------LGKPKKKSGSQRH--SAGNIDYD 1888
            ||:.::|           .:|.                    .|....|....||  |..:...:
 Worm   815 QQMPVIHRKCSSMDSQAVAAHAHLNYMHRSSAVSSTEQLDRHSGTDSMKCSPPRHKLSVASCHAN 879

  Fly  1889 NLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQ 1953
            .||.|:.:.||..|:|.       .:|...:|   |.||.:         |.||....:|:.:..
 Worm   880 PLSSSKSSVDLYVSLGA-------ENGDIERP---RSRSNS---------SGPEIEGLKQRSRSS 925

  Fly  1954 QQQLMQQGHAHAHPHPHPHPREPPPPPIR-QPHLHHHSSD-IERIDPGTKSEGEEDSQQG--TIR 2014
            .....:.|.......|..:      .|.| .|.|...|.| :|.:..|.:.|....:..|  .::
 Worm   926 SPDQKELGTPAQIGSPQTN------TPCRDSPTLLITSDDCVEPLQFGRRFEKRYHTADGIDVLK 984

  Fly  2015 PKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSS--HPPASYQPVLMKDLGKPSPDESELESES 2077
            ||  :.:.|..:....:.....|:.||..:.::||  :..|| ....:...|..:...|...|.:
 Worm   985 PK--ISKLPGAILKRFSLNGGSGAVGSSCKKLESSKRNSQAS-NAASLDSFGSSTSGISTASSNN 1046

  Fly  2078 E-----------VHAAQVAASFN-LSLGSSGSLFASDARDNQTQSRTQSQIHSLH---PSPRQSP 2127
            .           .|.:.::.:.: .|:.|.|:|..|.........:.:.| ||:.   |.|.:.|
 Worm  1047 NDPSMETLTSKLSHISTISINDSPSSIDSQGTLSISLEAPPTVLEKDEDQ-HSIEVSVPPPPELP 1110

  Fly  2128 RQSPRQSP 2135
            ..|...||
 Worm  1111 PPSKTPSP 1118

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413 20/87 (23%)
PDZ_signaling 1221..1308 CDD:238492 13/101 (13%)
RhoGEF 1456..1647 CDD:238091 49/202 (24%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/213 (17%)
PH 1693..1812 CDD:278594 23/129 (18%)
rhgf-2NP_001368191.1 RBD_PLEKHG5 186..262 CDD:340588 14/84 (17%)
RhoGEF 419..608 CDD:238091 49/202 (24%)
PH_PLEKHG5_G6 665..765 CDD:270064 24/132 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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