DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and unc-73

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001021496.1 Gene:unc-73 / 171988 WormBaseID:WBGene00006805 Length:2488 Species:Caenorhabditis elegans


Alignment Length:2300 Identity:426/2300 - (18%)
Similarity:730/2300 - (31%) Gaps:807/2300 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   490 LYLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQ-----------DQSYGQQQSSGQH 543
            |..|.|:.:..:.|...|...:||.:.:..|..:.|..:|.           .:...:::|:..|
 Worm   323 LSAEFEQFQIAVRGMEVSVKQVFDKENHLRTIGARNQITDHVAARLAEEWHLVKELMERRSAVLH 387

  Fly   544 PQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALL 608
                 ...:..:..|.:..:.|..|..||...:.:|...| .|...:.|           .:|..
 Worm   388 -----NAKEFFTSAQRYFAEVPRWTAQPGVNPNDVLFNQE-SLEEAIRK-----------HDAFW 435

  Fly   609 SQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERD------RDRDGYYS 667
            :|..|               .|.....:|...|..|           ||.|      |:......
 Worm   436 AQVEE---------------VYAQAYDDASKVTRAL-----------KEADAEDNVAREHSSRLQ 474

  Fly   668 DRNELIRERERERD-------------------RGYLSDHNSSFSNSRCASCIGES---ARAQWF 710
            ..::.:.|:.:||.                   ..:|..|...:......  |||:   ||:...
 Worm   475 RAHKQLMEKWKERQVLLHHMLAMIAFETDVRLVVDWLEQHGEPYLRRNIH--IGENVNQARSFQR 537

  Fly   711 RHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRA 775
            .|::..|..::|.|:......:.|.:..||.|....|::..|..|.|.     |..:...:|...
 Worm   538 NHTNFQRVAANTYGNVQKLHQVYQDVTKSGSKICDVDTMHGLMTDLSA-----KIEKFTKIENSR 597

  Fly   776 E-FIRQDSLRSEYLSDRESRYGIV--------------------QQASIESTDSRMCYLTSSEIS 819
            | .:||..|...:..:....||.:                    ::..:|:.::...|..:.:..
 Worm   598 ELLLRQSVLFHTHYKELTDWYGKMGEKYKDRRIDLTVPTCDKNKERFVLETDETAQAYAMTIDEG 662

  Fly   820 DD--DRMSLTTAVSDEDDGESV-----MASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRK 877
            ..  :.|...|.|.|.|...||     :.|..:.|.|     ..:...:.|:.......|:.:.:
 Worm   663 KTLIEMMQRATRVFDVDYSASVAHIQLLISDIEDKNT-----QISSEWSPRRTLLHIASKFAMFE 722

  Fly   878 KHQIE-LARKRGWKGYWVCLK------------GTTLLFYPCDSREGRS----VEAAPKHLIIV- 924
            ::|.| |.:.:.|:   |.::            .:.|.|:..:.::.|:    ::.:.|.|... 
 Worm   723 QNQFEVLEQIKSWE---VDMREMAESDSFYDKADSVLPFHKDNQQQVRNAIADIQKSAKELSQAL 784

  Fly   925 ------------DGAIMQPIPEHPKRDYIF---CLSTAFGDAYLFQAPCQV-ELENWVNSI---- 969
                        |..:::.|.||.:...|.   .::.|...:...||..:| :|....||:    
 Worm   785 YSQKLTDLRDKRDRVVLEAIREHVRELEIAESRVMTYANETSMRMQAASEVGDLRRISNSVCKLI 849

  Fly   970 ---HSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLK--------HMAELQQSVVTDQET 1023
               .||.............|:. .|||:.....|::  ||||        ...||.::.:.::: 
 Worm   850 DNQLSALTQLGVIPNDYNDTVQ-KQEELRAFRDAVQ--HKLKEPYDAFVIRFRELMENRLANRD- 910

  Fly  1024 RHQIQTQILQWEENLERLHCEQFRL------------RCYMASLQSGELPNPKSLLTHVSRPTKN 1076
                  :::...|.::..:|....|            .|| .:.::..||....|.:....|   
 Worm   911 ------EVVYHNEAIQAKYCRLMNLCEDRNKLLKSAHGCY-KTYETAVLPILNQLESEYHSP--- 965

  Fly  1077 TLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKT 1141
                    ||:.:    ||...|.::   |.|.|..  ..:||:          .|:.::...|.
 Worm   966 --------TVTDW----CAGCTSSID---ADRAAYV--ADLLSK----------HMDYKERFGKG 1003

  Fly  1142 FKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIEN 1206
            ...|:.:..:...|:|              |..:|..|......|..||:  |.....:::::|.
 Worm  1004 CTYALRNGDFLLRYIR--------------RSTVNQSERKRHETKIADMK--NNIRERQSNILEL 1052

  Fly  1207 YLHNHEFVEVCMKILYQVELQRTTLEQMWG--------FSVEAELIENAERQDELCCYVSRVEDK 1263
            ::.....:|.|...::.....:..||.|.|        |..:... |:.:..||...:.|.|:.|
 Worm  1053 WMQKKLLLEGCQSFIFIEASAKELLEFMKGEGNRKLKHFEKKGRR-ESTDDDDEFAKFKSEVKQK 1116

  Fly  1264 SVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMI 1328
            ...:...::......:..|....::|.. :|.|..|      ..|.||          ||.|   
 Worm  1117 KTDIQTFLMLSTNETMSRGVHGDEIDRC-IEQVKDE------FSRFSR----------RVGD--- 1161

  Fly  1329 DSLVCPPPPTDPPVMSEEMITGLIVPAPGWNG---TSKDLYSPEAESSPATSFVDPAAMAAQLAV 1390
                |.                  |...|.||   :|||.:|.:..|.                 
 Worm  1162 ----CE------------------VVLRGENGSTQSSKDEFSLDRHSD----------------- 1187

  Fly  1391 GGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEK 1455
                               |:.|. |..:....:|.||              .|.|.|       
 Worm  1188 -------------------TAIFN-EKKINERREENRK--------------MLEPMR------- 1211

  Fly  1456 LRKVVMELVDTERTYVKHLNNLLEHY---------------LEPMKRETFLSNAEINALFGNIHE 1505
                  ||:.:||.|:|.|...:..|               |.|:|.|          :||||.:
 Worm  1212 ------ELIQSERDYIKDLERCVNIYVKEFDQAAKNGTIPTLNPLKYE----------IFGNIEK 1260

  Fly  1506 IVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF-KLYSSFCASHSKAQK 1569
            |..|....|  |.|.:             ::.|...|:|::|:.:::.. :||:.:|.  :|.||
 Worm  1261 IFKFHNDKL--LHELI-------------KYENQPEAVGASFIVWIDLLNELYTEYCV--NKEQK 1308

  Fly  1570 VLHPNEGNH------ALQEFLAARNPKQQH----SSTLESYLIKPIQRILKYPLLLQQ-MRNLTD 1623
                   ||      |:..|...|   ::|    ::.:.|.||||:|||.:|.||::| ||:.||
 Worm  1309 -------NHVIATPDAVSFFTGIR---ERHGLEINNEIASLLIKPVQRITRYRLLIEQLMRSCTD 1363

  Fly  1624 TRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGV 1688
            ...|                        :.|.|..:           |..|..::  ||::|   
 Worm  1364 KTND------------------------LKEAYEVV-----------CSVPRKVN--DLIHY--- 1388

  Fly  1689 EWLNISDF----LGKIK--------------KGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVS 1735
            ..|::.||    ||...              ||.......|:|..::||         .|.:.||
 Worm  1389 NCLDLKDFKVDELGPFVTQDTLTFWEPRAYFKGRGKERQVFLFDISIVF---------AKRIEVS 1444

  Fly  1736 SKNATNEVEIIRYQVL---IPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNS-- 1795
            .||       |:|.:.   :|::||.:               :.|:.....|...:|..:|::  
 Worm  1445 PKN-------IKYVIKGKPLPLSEVSI---------------VEHVEGDTCRFGLRVGTVSSNDN 1487

  Fly  1796 ----TADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMG-SMGYPGNSQTLERP 1855
                .|:..:..:|.: |.||:....| :|:                |:| |..|...:.:..| 
 Worm  1488 RIDLKANNHHTKVKWV-QKIRDLTAGM-LPL----------------GLGVSEAYSVGTLSTAR- 1533

  Fly  1856 KQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQ- 1919
              .:::..|:.|      .||.:...           ||:.:.|     :.|..|.|:...:.. 
 Worm  1534 --SVSVRSGAST------SSGGENRQ-----------SQDVESL-----LRHRYSVHSCDSEQSS 1574

  Fly  1920 -----PAGFRGRSK---TV--GDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHA-HPHPHPHP 1973
                 .|.|.|:.:   ||  ||..||.     ..|.....:..|..|..|...|. .|.....|
 Worm  1575 EVWIVTADFDGQVEGHLTVHKGDRVEIV-----EDQATDCAEYVQVVLCDQPTKHGLVPASIIAP 1634

  Fly  1974 REPPPPPIRQPHLHHHSSDI---------------ERIDPGTKSEGEEDS-----QQGTIRPKAT 2018
            .|....|.|....:...|.:               ||......|....:|     ...|..|...
 Worm  1635 PESGSVPDRPDDSNASGSTVSKRKSLRRIFANSSKERAAAANSSSSNNNSPATRQSTSTSSPVTA 1699

  Fly  2019 LGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHP--------PASYQPVLMKDLGK-----PSPDE 2070
            .|.|....|.:....||.|...|...:..||.|        ||:..|:::.:..|     |.|.|
 Worm  1700 NGHTTESSTSAPIGVLSSGEPTSSNSIPSSSTPTHTVPSSVPATVIPIVVAEDEKAEDCLPPPME 1764

  Fly  2071 SELESESEVHAAQVAASFNLSLGSS--------GSLFASDARDNQTQSRTQSQIHSLHPSPRQSP 2127
                              |:::.:|        .|:.||||.:.:.         :|.....::|
 Worm  1765 ------------------NITINNSIDEKDMNEDSVAASDAVEPEV---------ALPAKVEKTP 1802

  Fly  2128 RQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQH---------PSDQARESG---------- 2173
            .::.|.  |:...::|:.|:|.:.:  ....:||..:         |:|...:..          
 Worm  1803 EETARF--KRSYVLMELVETEQDYV--KDLTSVVEGYIGNLNKMDLPADLVGKDKIIFANIVNIL 1863

  Fly  2174 --HKQR--RDRDRNPTETDAT-ARFM---------------DKHLSD--LEQENLTD-------- 2208
              ||..  ::.::.....:|. |.|:               :|..||  |.|::...        
 Worm  1864 EFHKTNFLKEIEKCSENYEAAGAAFVKYERRLHTLYVTYCQNKPKSDYLLAQDDFEAFFADTKAK 1928

  Fly  2209 -----GTCD--------IVAYMESLR------EKAFDPQDLAE-----------------DTGDH 2237
                 ..||        |:.|...|:      |:|.|..|..:                 ..|..
 Worm  1929 LGHKVALCDLLIKPVQRIMKYQLLLKDILKFTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRL 1993

  Fly  2238 QQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDS-TGNTTGPSERSGDETEEEATTSSLAS 2301
            |..|.|||.:.:.|.:.|.|.              |:| .||...|.:|.....|:.|.   :|.
 Worm  1994 QNFDKSLSAQGKLIHQGTLQI--------------SESIAGNVQKPKDRRIFLFEQSAI---IAD 2041

  Fly  2302 HI----------------VVIDKKVDKIFKAKSPERPASTKVKGGRRQIYISPDRCKSQGSSPVR 2350
            ||                .:::|.|   |:...|:.|....:|             .|..:.|..
 Worm  2042 HIPPKKEFGNPTYIFKSQFMVNKMV---FEPNVPDDPLRFVIK-------------SSDPTQPTS 2090

  Fly  2351 IIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRR---SSEGGGILKHTTGPDPGILK 2412
            .|.....:....:..:::|...   :.|.||.|.  ...|||   .|.|.|.|  :.|...|..:
 Worm  2091 FIANAQSQEEKDEWNRKMSELL---DQQKRLLAA--LVDPRRYNDMSSGMGDL--SLGAPGGDRR 2148

  Fly  2413 -PPSS-----PAKSKSPDRSCLKKG 2431
             .|||     .:.||.|..|..|:|
 Worm  2149 GAPSSANRSAASSSKKPAESPKKEG 2173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 26/165 (16%)
PH 873..974 CDD:278594 24/141 (17%)
TIAM1_RBD 1141..1219 CDD:176413 13/77 (17%)
PDZ_signaling 1221..1308 CDD:238492 16/94 (17%)
RhoGEF 1456..1647 CDD:238091 54/217 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 39/199 (20%)
PH 1693..1812 CDD:278594 27/145 (19%)
unc-73NP_001021496.1 SEC14 19..156 CDD:214706
SPEC 422..568 CDD:295325 30/185 (16%)
SPEC 849..1063 CDD:295325 46/270 (17%)
RhoGEF 1208..1383 CDD:238091 60/259 (23%)
PH-like 1391..1509 CDD:302622 30/149 (20%)
PH 1419..1511 CDD:278594 25/123 (20%)
SH3 1575..1634 CDD:302595 15/63 (24%)
RhoGEF 1813..1986 CDD:279015 26/174 (15%)
PH2_Kalirin_Trio_p63RhoGEF 1990..2128 CDD:270061 36/175 (21%)
I-set 2305..2391 CDD:254352
Ig 2335..2392 CDD:299845
FN3 2395..2473 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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