DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Arhgef1

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_006539628.1	Gene:	Arhgef1 / 16801	MGIID:	1353510	Length:	980	Species:	Mus musculus

Alignment Length:	797	Identity:	165/797 - (20%)
Similarity:	267/797 - (33%)	Gaps:	241/797 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 VGIMRVTDDMIDS----LVCPPPPTDPPVMSEEMITGLIVPAP---------GWNGTSKDLYSPE 1369
            |.:..::.|.:||    :..|..|.|.|......:..|..|..         .|...|..|  ..
Mouse   322 VSLHPLSTDSVDSREPGVDTPQEPGDTPPQGPTSLEPLAPPESTEDNGETERRWKRLSGRL--GR 384

  Fly  1370 AESSPATSFVDPAAMAAQLAVGGVGG---------------VVVGGLGVAKPTSRT--------- 1410
            :||...:....|:  ...|...|.||               .|:|      ||.|.
Mouse   385 SESLRVSDRRRPS--RGSLGAKGRGGGRSRSDVDMDPGSATAVLG------PTRRATPEPGDDGE 441

  Fly  1411 ---SSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALT-PSRQLTDAEKLRKVVMELVDTERTYV 1471
               |..|:|           ...|.|........|.|: |..|:    |.::|:.||:.||..:|
Mouse   442 PGRSGLELE-----------PEEPPGWRELVPPDTLLSLPKSQV----KRQEVISELLVTEAAHV 491

  Fly  1472 KHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNL----EESLDLEPDFNKFEH 1532
            :.|..|.:.:.:||....|....|:..:|.::.|::.....||..|    :||..|      .|.
Mouse   492 RMLRVLHDLFYQPMADGGFFPLDELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL------IEE 550

  Fly  1533 CGQFRNVLF--AIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHA-----LQEFLAARNPK 1590
            .|......|  |.||.|.      |:.|.||:..|.|.:.|...:....     :||  |...|:
Mouse   551 IGDVLLARFDGAEGSWFQ------KISSRFCSRQSFALEQLKAKQRKEPRFCAFVQE--AESRPR 607

  Fly  1591 QQHSSTLESYLIKPIQRILKYPLLLQQM-RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHE 1654
            .:... |:..:...:||:.|||||||.: :|..::.....|.|  |.:...::..|:|:..|..|
Mouse   608 CRRLQ-LKDMIPTEMQRLTKYPLLLQSIGQNTEESTERGKVEL--AAECCREILHHVNQAVRDME 669

  Fly  1655 EYGAIFDHLFR---QHQKSCKQP-------IDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAM 1709
            :...:.|:..|   .|.:....|       :|::...|::.|.:.|....|      |.:|:|
Mouse   670 DLLRLKDYQRRLDLTHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKD------KAIEVH-- 726

  Fly  1710 CFVFKSAVVFLCKERL----RQKKKLMGVSSKNATNEVEIIRYQVLIPV---TEVQVR--ASSAK 1765
                    |.|..:.|    ||.::|: :.|.:.|.........:|.||   |....|  |:..|
Mouse   727 --------VLLLDDLLLLLQRQDERLL-LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHK 782

  Fly  1766 DMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSG 1830
            .....|.|:          :..::|.|...|:..|    |....:|.|:..::.:|
Mouse   783 AFYVIFTWD----------QEAQIYELVAQTSSER----KNWCNLITETAGSLKVP--------- 824

  Fly  1831 SVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQE 1895
                                   .|..::          ||:....|.|...       ||.|:.
Mouse   825 -----------------------APASRL----------KPRPSPSSIREPL-------LSSSEN 849

  Fly  1896 ADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQ----QQQQ 1956
            .                |.|.:|.||..| ..:.:.|:.......||........|:    :|..
Mouse   850 G----------------TGGAEMAPADAR-TERLLNDLLPFCRPGPEGQLAATALQKVLSLKQIL 897

  Fly  1957 LMQQGHAHAHPHPHPHPRE-------PPPPPIRQPHLHHHSSDIER----IDPGTKSEGEEDSQQ 2010
            |..:..:.|.|     ||:       ..|.|:       |:.:||.    ::...:...|.:.:.
Mouse   898 LSTEEDSGAGP-----PRDGDGVPGGRAPGPV-------HTQEIEENLLSLEVAIRQLEELEEEF 950

  Fly  2011 GTIRP-KATLGRT--PN 2024
            ..:|| .:.||.|  ||
Mouse   951 CRLRPLLSQLGGTLSPN 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	53/202 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957	39/191 (20%)
		PH	1693..1812	CDD:278594	26/127 (20%)
Arhgef1	XP_006539628.1	RGS_p115RhoGEF	50..242	CDD:188709
		PHA03247	<277..462	CDD:223021	30/160 (19%)
		RhoGEF	479..663	CDD:214619	53/200 (27%)
		PH_p115RhoGEF	697..821	CDD:275429	32/154 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910