DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Arhgef2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006501121.1 Gene:Arhgef2 / 16800 MGIID:103264 Length:1185 Species:Mus musculus


Alignment Length:1396 Identity:251/1396 - (17%)
Similarity:444/1396 - (31%) Gaps:477/1396 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1000 AIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCE------QFRLRCYMAS---- 1054
            |:||..:|:.:           |.|.:.|      |:|.:..|..      .||.|.|...    
Mouse    27 AVESREQLEEV-----------EGREENQ------EDNKDGFHTSLLRRSGAFRARSYTTDSFKR 74

  Fly  1055 -----------------LQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLN 1102
                             |||.|.|..:      ..|...:|.:||.                   
Mouse    75 HSWGPGKEFQDPISRRRLQSSECPGSQ------EAPFLQSLEELGT------------------- 114

  Fly  1103 NLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTF----KVAMPDNAYS----TVYLRDA 1159
                         |:      |:.::..|.....:..:.|    ....|..|.|    |..|..|
Mouse   115 -------------PL------GAQQQEQQQGQEQQRGQPFHRGQSFCYPSAASSVPSVTGMLSKA 160

  Fly  1160 MSVEEF-LASACARRNLNPMEHFVRVKKR-----------------------------RDMEDHN 1194
            :|:.:. |.|.|:..|.|..:.:|....:                             ||.....
Mouse   161 VSMSDINLLSDCSDPNGNSPQSYVTDLSKCGKQLEEDSGTWAGSSLRRTFSFLLGMTGRDKTREK 225

  Fly  1195 YFVPHRNDLIENYLHNHEFVEVC---MKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCY 1256
            ..:....|  ..|.:.|.|..:.   |.:.|......|..|.:...:....:....:.....|..
Mouse   226 EKMKEAKD--ARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTK 288

  Fly  1257 VSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIM 1321
            |.:.:.|:..:.|           |.|:                ||:|:..:::..|.|      
Mouse   289 VKQKQQKAALLRN-----------NTAL----------------QSVSLRSKTTTRERP------ 320

  Fly  1322 RVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWN----GTSKDLYSPEAESSPATS----- 1377
                                       |..|.|:..:.    |:.:.|.|.....|.:|:     
Mouse   321 ---------------------------TSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGH 358

  Fly  1378 FVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFE------IE---NLLKTAEQETRKSSPTG 1433
            |.|.:.:       |:..::..........:||.|.|      :|   |.|.:..:...|.....
Mouse   359 FNDESPL-------GLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEAD 416

  Fly  1434 SVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINA 1498
            |.:.:|.::.|...::  :..|.:.|:.||:.||..:|:.|..:...:...|..|..:....:..
Mouse   417 SWSLAVDSSFLQQHKK--EVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQG 479

  Fly  1499 LFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHC-GQFRN-VLFAIGSAFLYYVNHF------- 1554
            ||..:.|:.....:||..|.|.       .:...| |..|| |:..:|...   ::.|       
Mouse   480 LFPCVDELSDIHTRFLNQLLER-------RRQALCPGSTRNFVIHRLGDLL---ISQFSGSNAEQ 534

  Fly  1555 --KLYSSFCASHSKAQKV---LHPNEGNHALQEFLAARNPKQQHSSTLESY-----LIKPIQRIL 1609
              |.||.||:.|:||.|:   |:..:  ...|:|:.    |...|:.|:.:     ::...|||.
Mouse   535 MRKTYSEFCSRHTKALKLYKELYARD--KRFQQFIR----KMTRSAVLKRHGVQECILLVTQRIT 593

  Fly  1610 KYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHE-EYGAIFDHLFRQHQKSCKQ 1673
            |||:|:.::...:....:|:..|..||..::::..:::  |.:|| |..|....::.:.....:.
Mouse   594 KYPVLINRILQNSHGVEEEYQDLASALGLVKELLSNVD--QDVHELEKEARLQEIYNRMDPRAQT 656

  Fly  1674 PIDLSPG------------DLLYYGGVEW------------LNISDFLGKIKKGLELHAMCFVFK 1714
            |:   ||            .|::.|.:.|            |.::|.|..:::..:.:....:.|
Mouse   657 PV---PGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLDK 718

  Fly  1715 SAVV----FLCKERLRQKKKLMGVSS-------------KNATNEVEIIRYQVLI-------PVT 1755
            .:||    .:.::...|.|.:..:||             .:.|..:.:|:..|.:       |:.
Mouse   719 PSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLI 783

  Fly  1756 EVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTAD---------------------- 1798
            |.:.:|            .|..::::||::::.:..|.....:                      
Mouse   784 ETEDKA------------YLRRIKTKLQQKNQALVELLQKNVELFAEMVHFQALKAGFVGMPPPA 836

  Fly  1799 -----FRNAFLKTIR--QIIRESVRN------------MSIPMKN------FGGSSGSVSGHSSQ 1838
                 ||....:::|  :::::::|.            :.:||.:      ....|||..|.::.
Mouse   837 LPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPMTSREPALPLDSDSGSCPGVTAN 901

  Fly  1839 GMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSV 1903
            |                  :....:||..|.:....| ||:...||    .|...|| :.|.|.:
Mouse   902 G------------------EARTFNGSIELCRADSDS-SQKDRNGN----QLRSPQE-EVLQPLI 942

  Fly  1904 ---GVVH----------------YASGHTHGQQMQPAGFR----GRSKTVGDVTEITCSSPEPHQ 1945
               |::|                :..|....:::..|..|    ||: .|..||      ||...
Mouse   943 NLYGLLHGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRA-AVASVT------PEKQA 1000

  Fly  1946 QQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQ 2010
            .:....|:|..|:|:..............|......|........:.:||       |.||..:|
Mouse  1001 TELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLER-------EAEEIRRQ 1058

  Fly  2011 ----GTIRP---KATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQ-------PVLMK 2061
                |...|   :|...|.|..   ....:|..|..     |..|.:||...:       ||.::
Mouse  1059 LAALGQNEPLPAEAPWARRPLD---PRRRSLPAGDA-----LYLSFNPPQPSRGHDRLDLPVTVR 1115

  Fly  2062 DLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQS 2126
            .|.:|..|....|                 |||..... .|:.|..|.|..:       .|.|.|
Mouse  1116 SLHRPFDDREAQE-----------------LGSPEDRL-QDSSDPDTGSEEE-------VSSRLS 1155

  Fly  2127 PRQSPRQSPK-QDIEVIEIFESEAERLAASQ 2156
            |..|||...: |||.  |..||......||:
Mouse  1156 PPHSPRDFTRMQDIP--EETESRDGEPTASE 1184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413 20/118 (17%)
PDZ_signaling 1221..1308 CDD:238492 12/86 (14%)
RhoGEF 1456..1647 CDD:238091 49/209 (23%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/262 (14%)
PH 1693..1812 CDD:278594 22/171 (13%)
Arhgef2XP_006501121.1 C1 240..285 CDD:237996 6/44 (14%)
RhoGEF 437..631 CDD:238091 49/209 (23%)
PH_ARHGEF2 671..786 CDD:275428 18/114 (16%)
TIGR02680 <1000..>1072 CDD:274256 14/78 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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