DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and AgaP_AGAP006188

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_001688819.1 Gene:AgaP_AGAP006188 / 1276854 VectorBaseID:AGAP006188 Length:1633 Species:Anopheles gambiae


Alignment Length:1787 Identity:347/1787 - (19%)
Similarity:599/1787 - (33%) Gaps:579/1787 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   500 CIEGSPPSDNVMFDNQCYA----TTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHH 560
            ||...|.:..    .:.||    |:|.|:.|.:....:.....::.|       ||..|..::..
Mosquito   157 CIRPEPDTSK----PELYAVWRGTSPPSAAGAAPASSTVACSSATTQ-------PPHPSIVYRRL 210

  Fly   561 HQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAES-LPGS 624
            ......|||                    ||..|..|.     ..|||...:..:|.|.| :|..
Mosquito   211 DPIRDPVTP--------------------LAVEMLTED-----LPALLQNLLVGIERAISRVPLE 250

  Fly   625 NQRSPYP---LRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERE------- 679
            :...|.|   |..|.:.::|....|..|         |.|.:|      ||:.|..|.       
Mosquito   251 DLSFPTPDGGLTVPASVTTTATTAPSDP---------DGDENG------ELLNEAGRSPAANNST 300

  Fly   680 ---------RDRGYLSDHNSSFSNSR--------CASCIGESAR---AQWFRHSDGWRSGSSTIG 724
                     :.|..::.:|....||:        .|:.:...|.   |...:|..|     :..|
Mosquito   301 PGTPKLGLLKRRELITKNNKLLINSKYTQLKRQPLAATVVSGANLSTAGSHQHRPG-----AIGG 360

  Fly   725 SGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLS 789
            :.:|||       |:|.|..  ::||.: ..:..||.                            
Mosquito   361 NQNGHG-------GTGGKSE--NALPQI-GSNQCNDG---------------------------- 387

  Fly   790 DRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAAS 854
                       .|:...|:.........::.|::.|  |||   |.|.|..|:  .|..|.:|..
Mosquito   388 -----------LSVTICDTGGVEGGGGGLAGDNQQS--TAV---DAGASAAAA--AAAVTPSAGM 434

  Fly   855 SFNCTGAV-------------RKAG----FLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLL 902
            ...|.|..             .::|    ::.|:|.|....:..|:|              |.||
Mosquito   435 PLFCLGGSFPHIDSDEESRTHDRSGTPIIYIEVEKTLASGLNCYEIA--------------TVLL 485

  Fly   903 FYPC----------------DSREGRSVEAAPKHLIIVD----------------GAIMQPIPEH 935
            :|..                :|.:...::.....|.::|                |.:.|....|
Mosquito   486 YYNTLPIQRPTHYALHLLVNESGQLHFLDTIESTLQLLDGHLKLSAVFVSGGYDAGGVDQQQQHH 550

  Fly   936 PKRDYIFCLSTAFGDAYLFQAPCQVE--------LENWV--NSIHSACAAAFARHRGKTGTLHLL 990
            |.::|:              .|..|.        ::|::  :::...|...:...:.:......|
Mosquito   551 PPKEYL--------------RPGSVRVRYLNNETVKNFISTDNLPIQCCGFYVHDQREWVDFFQL 601

  Fly   991 QEEIFRLEKAIESDHKLKHMAELQQSVVTD------QETRHQIQTQILQWEENLERLHCEQFRLR 1049
            .|::  .::.:|:..:|       .:|:.|      ..||.|:.:|    ...|.|...:     
Mosquito   602 LEQL--QQQCVETGRRL-------VAVLGDLRGNGTATTRRQLHSQ----HRALSRALMD----- 648

  Fly  1050 CYMASLQSGELPNPKSL------LTHV-SRPT-KNTLNKLGVFTVSSFHAFICARSPSLLNNLLA 1106
               :.|||.....|.::      ||.: :|.| |.|.|.:...:|.|     .||...::|..||
Mosquito   649 ---SELQSLRRKGPNTIQRLQDKLTVINNRQTLKQTKNLVRALSVDS-----SARGSDIINGRLA 705

  Fly  1107 G----RGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTV-YLRD--AMSVEE 1164
            .    .|...|....|.:.......|..:|        |.:.|:.|.....: ::|:  ..|:..
Mosquito   706 EVIAIYGEVDRAARKLEQLTEQRRERLREM--------TRQRALDDEINEVICWMRNEGEQSLRT 762

  Fly  1165 F---LASAC---ARRNLNPMEHFV-----RVKKRRDMEDHNYFVPHRND---LIENYLHNHEFVE 1215
            |   .|..|   |:.:....|.|.     .|.|.||:.|.:..:....|   |:::.:  .||.|
Mosquito   763 FSDPAALECPDAAKESETQFEQFYYTARKHVSKGRDLCDASGELEIMRDNLKLLKDCV--DEFQE 825

  Fly  1216 VCMKILYQVE----------LQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNG 1270
            ...::..::|          :|:..|:.    .:..|:::.||:.|.....:.|....|:. |.|
Mosquito   826 RLERVRERIEGAARLHSLLGMQQLKLDD----DIRTEMLKLAEKIDAPGRLIERCRRLSMP-HGG 885

  Fly  1271 IIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPP 1335
               ||:....:|               :||.:|:..: .:.||..|..|     .|....:....
Mosquito   886 ---GDQNDSASG---------------KEEDTLATPL-PTLTEQGDDQG-----QDASQGVTMRH 926

  Fly  1336 P-------------------PTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAE-SSPATSFVD 1380
            |                   ..:...:|:...:||       .|..:...:.:.| :....||.|
Mosquito   927 PKGHHHHHHHHHHHHHHQRHDEEDEELSKMADSGL-------GGCDRCEGNAKLERTCSCQSFDD 984

  Fly  1381 PAAMAAQLAVGGVGGVVVGGLGVAKPTS-------RTSSFEI---ENLLKTAEQETRKSSPTGSV 1435
            |..:...|......|:....|.:..|..       ..|:.::   ||  ...:|:|:|:      
Mosquito   985 PKNVCDDLDEDCFEGISKPPLDLQIPLQANAHLYCHASNLQLDYEEN--NPFDQKTQKT------ 1041

  Fly  1436 TSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETF--LSNAEINA 1498
                                |..::.|::.|||.||:.|..::|:|.:.:.||..  ....:.|.
Mosquito  1042 --------------------LLLIMREMIGTERDYVRSLQYVIENYTQELLREDIPQALRGQRNV 1086

  Fly  1499 LFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCA 1562
            :||||..|..|.|| ||..| ||.:..|               ..:|:|||.:.:.|.||:.:..
Mosquito  1087 IFGNIERISEFHRQHFLSEL-ESCEHHP---------------LKVGTAFLRHESKFYLYALYNK 1135

  Fly  1563 SHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQ-MRNLTDTR- 1625
            :..|:..::..|.     .:|...:..:......|.|||:||:||:.||.||||| |:...|.: 
Mosquito  1136 NKPKSDSLMSENG-----TQFFKTKQIELNDKMDLASYLLKPVQRMGKYALLLQQLMKACADLQH 1195

  Fly  1626 ADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEW 1690
            .:.:..:.|.|:.::|.    .||.|....:|.  |.|.....:.|...:. ..|.|        
Mosquito  1196 TNSNAEILEDLEMLQKA----EEMVRFQLRHGN--DLLAMDSLRDCDVNVK-EQGRL-------- 1245

  Fly  1691 LNISDFL---GKI-KKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVL 1751
            |..::||   ||. ||.|.   ..|:|:..|:|....|...:|.|            :|..|:..
Mosquito  1246 LRQNEFLVWEGKAGKKSLR---QVFLFEELVLFSKARRFPDRKNL------------DIYIYKNS 1295

  Fly  1752 IPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQII-RESV 1815
            |..:::.:.|...   ||.:.:| |..|   :|:....:.|...:.|.:||:.:.|.::: :::.
Mosquito  1296 IKTSDIGLTAHVG---DSPYRFE-IWFR---KRKPGDTWTLQTMSEDVKNAWTEEISKLLWKQAK 1353

  Fly  1816 RNMSIPMKNFGGSSGSVSGHSSQGMGS---------------------------------MGYPG 1847
            ||..|.:...          ||.|:||                                 ||...
Mosquito  1354 RNREIRLAEM----------SSMGIGSKPCLDIRPSQDQINDRSISISQLGKAPKLRNSFMGTLP 1408

  Fly  1848 NSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAG-NIDYDNLSGSQEADDLPPSVGVVHYASG 1911
            .|::.:||:..|::  .|.:.|.....:|:...::| .....::||:..:     |.|....||.
Mosquito  1409 ESKSSKRPQSIISV--SSSSSGSSSVSTGTSSTTSGCEATTVSVSGNSNS-----SSGTSSAASN 1466

  Fly  1912 HTHGQQMQPAGFRGRSKTVGDVT--------EITCS-----SPEPHQQQQQQQQQQQQLMQQGHA 1963
            .........:...|.|......|        .:|.|     :|.|.:...::.|:...|:.|...
Mosquito  1467 SGSSSSSSSSSSSGSSSASSTTTTSITTAGKRLTLSITDPNAPAPLKTSYKKHQRSTTLVSQCSM 1531

  Fly  1964 HA---------------HPH-PHPHPRE-----------PPPPPIRQPH----LHHHSSDIE--- 1994
            .:               :|| ||.||..           |....:::.|    ..|.|..|.   
Mosquito  1532 ESGIIADISLSPDEVLDNPHWPHHHPHHHNNNNNNNHHLPKHTNLKKTHSLASSTHSSGPISLPI 1596

  Fly  1995 ---RIDPGTKS-EGEEDSQQGTIRPKATLGRT 2022
               ..:.|||. :|:.|:...|:.|....|.|
Mosquito  1597 TLLPSEDGTKGVDGKPDTLSPTVEPAGDNGTT 1628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 23/183 (13%)
PH 873..974 CDD:278594 18/142 (13%)
TIAM1_RBD 1141..1219 CDD:176413 21/94 (22%)
PDZ_signaling 1221..1308 CDD:238492 17/96 (18%)
RhoGEF 1456..1647 CDD:238091 57/195 (29%)
PH2_Tiam1_2 1650..1823 CDD:269957 40/177 (23%)
PH 1693..1812 CDD:278594 29/123 (24%)
AgaP_AGAP006188XP_001688819.1 SPEC 635..835 CDD:295325 47/226 (21%)
RhoGEF 1045..1225 CDD:279015 60/206 (29%)
PH_puratrophin-1 1217..1356 CDD:270062 38/171 (22%)
PH 1255..1348 CDD:278594 27/114 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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