Protein Alignment sif and FGD4

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: NP_001357227.2
• Gene: FGD4 / 121512
• HGNCID: 19125
• Length: 903
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 120/577 - (20%)
• Similarity: 215/577 - (37%)
• Gaps: 167/577 - (28%)

  Fly  1273 KGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPP 1337
            :|.:..|.||.:.:...|     ..:||::.::   ||.|.       ::.::.::|:.:.
Human   220 QGAQTCVANGVMAAQNQM-----ECEEEKAATL---SSDTS-------IQASEPLLDTHIV---- 265

  Fly  1338 TDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLG 1402
                                 ||...:  :..|.:||.|...|..|..:.....|:|.|:
Human   266 ---------------------NGERDE--TATAPASPTTDSCDGNASDSSYRTPGIGPVL----- 302

  Fly  1403 VAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQL--TDAEKLRKVVMELVD 1465
               |.....:   |...|..|:|..:        |.:....|....::  |:.:||.|:..||:.
Human   303 ---PLEERGA---ETETKVQERENGE--------SPLELEQLDQHHEMKETNEQKLHKIANELLL 353

  Fly  1466 TERTYVKHLNNLLEHY----LEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPD 1526
            |||.||..|:.|.:.:    ||...|.:|.:.. :|.:|.||..|..|..:||  |.|   ||..
Human   354 TERAYVNRLDLLDQVFYCKLLEEANRGSFPAEM-VNKIFSNISSINAFHSKFL--LPE---LEKR 412

  Fly  1527 FNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQ 1591
            ..::|...:..::|..: :.||      |:|..:......|.:::  ......:.:|.:.....|
Human   413 MQEWETTPRIGDILQKL-APFL------KMYGEYVKGFDNAMELV--KNMTERIPQFKSVVEEIQ 468

  Fly  1592 QH----SSTLESYLIKPIQRILKYPLLLQQ-MRNLTDTRADEHVHLCEALKGMEKV---AEHINE 1648
            :.    |.||:.::::|:|||.:|.:||:. :|.|.....|.:    :|.|.:|.:   |.|.|.
Human   469 KQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWN----DAKKSLEIISTAASHSNS 529

  Fly  1649 MQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGK-----------IKK 1702
            ..|..|....:                               |.|.:.||:           ||:
Human   530 AIRKMENLKKL-------------------------------LEIYEMLGEEEDIVNPSNELIKE 563

  Fly  1703 G--LELHA--------MCFVFKSAVVFLC---------KERLRQKKKLMGVSSKNATNEVEIIRY 1748
            |  |:|.|        ..|:|.:.::: |         |..:|.:..:.|:......||.....:
Human   564 GQILKLAARNTSAQERYLFLFNNMLLY-CVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTF 627

  Fly  1749 QVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLK 1805
            ||......::::||||:|.:.   |        ::...|.:.........||||..|
Human   628 QVSGKERTLELQASSAQDKEE---W--------IKALQETIDAFHQRHETFRNAIAK 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492	7/34 (21%)
		RhoGEF	1456..1647	CDD:238091	54/202 (27%)
		PH2_Tiam1_2	1650..1823	CDD:269957	34/186 (18%)
		PH	1693..1812	CDD:278594	31/143 (22%)
FGD4	NP_001357227.2	RhoGEF	344..528	CDD:238091	54/202 (27%)
		PH1_FDG4	560..653	CDD:275434	22/104 (21%)
		FYVE_FGD1_2_4	691..755	CDD:277280
		PH2_FGD1-4	774..876	CDD:270056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910