DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Mcf2l

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006253478.1 Gene:Mcf2l / 117020 RGDID:619782 Length:1280 Species:Rattus norvegicus


Alignment Length:1665 Identity:325/1665 - (19%)
Similarity:543/1665 - (32%) Gaps:555/1665 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   620 SLPGSNQRSPYPLR-----RPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERE 679
            ||||:.....:..|     ||  ..|.|||||..|.|.|..|            |..|...|.  
  Rat     4 SLPGAQVVHTHDSRCGVVTRP--AGSVLPLPPSAPRSPINAK------------RAPLPVARR-- 52

  Fly   680 RDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGS-GSGHGMMTQQIPGSGHKR 743
                                                     ..:|| |..|..:........|.:
  Rat    53 -----------------------------------------PILGSQGKRHNPLPAPAAPPPHAQ 76

  Fly   744 SPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDS 808
             |..:.|.:::.:....|..       |.:|..|    .||:|.::..|    :||:.:..|.: 
  Rat    77 -PHPTAPLVQRRTIFWGSVL-------LSRRMRF----WLRNEEMALEE----MVQRLNAVSKN- 124

  Fly   809 RMCYLTSSEISDDDRMSLTTAVSDE--------------DDGESVMASP-YKA------KATGTA 852
                  :.||...|.:.|..|...|              .||..|:..| |.|      |.....
  Rat   125 ------TDEIMHQDIVPLCAADIQEQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNV 183

  Fly   853 ASSFNCTGAVRKA--GFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVE 915
            .:......:::.|  ||:.|   :.|::.:            |..:|.:.|          |...
  Rat   184 MTYLTSIPSLQDAGIGFILV---IDRRQDK------------WTSVKASVL----------RIAA 223

  Fly   916 AAPKHLIIVDGAIMQPIP--EHPKRDYIFCLSTAFGDAYLFQAPCQV-----ELENWVNSIH--- 970
            :.|.:|.:|  .:::|..  :....|..|..:.   |.:..:.|..:     ||..:::...   
  Rat   224 SFPANLQLV--LVLRPTGFFQRTLSDIAFKFNR---DEFKMKVPVMMLSSVPELHGYIDKSQLTE 283

  Fly   971 ------SACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQ-------QSVVTDQE 1022
                  ..|.:.:..||....:..|:.::..::.:|..::     :||.:       .|:|....
  Rat   284 DLGGTLDYCHSRWLCHRTAIESFALMVKQTAQMLQAFGTE-----LAETELPNDVQSTSLVLSAH 343

  Fly  1023 T------RHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNP---KSLLTHVSRPTKNTL 1078
            |      :..:|..:.:....||.|  .:......:.|:...:|.|.   |.|||.::.      
  Rat   344 TEKKAKVKEDLQLALTEGNSILESL--REPLAESIVHSVNQDQLDNQATVKRLLTQLNE------ 400

  Fly  1079 NKLGVFTVSSFHAFICARSPSL-----LNNLLAGRGATKRRPPMLSR-----SNSGSSRRSMQMN 1133
                  |.::|..|.......|     |.:...|....|.....:|:     ::.|:|...:|..
  Rat   401 ------TEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKTALDSMSQKIAAFTDVGNSLAHVQHL 459

  Fly  1134 SRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFV------RVKKRRDMED 1192
            .:|              .:|...:.:::|::..|.:...:.|....|:.      :.::.:.:.|
  Rat   460 LKD--------------LTTFEEKSSVAVDKARALSLEGQQLIENRHYAVDSIHPKCEELQHLCD 510

  Fly  1193 HNYF---VPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWG----FSVEAELIENAERQ 1250
            |  |   |..|.||:...|..|..:|..||               |.    |.:.::.::..:.|
  Rat   511 H--FASEVTRRRDLLSKSLELHSLLETSMK---------------WSDEGIFLLASQPVDKCQSQ 558

  Fly  1251 DELCCYVSRVE-------DKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMR 1308
            |.....:..:|       :..:...|.|.|..| .::|    .|| :.:::.|.|:::|...|..
  Rat   559 DGAEAALQEIEKFLETGAENKIQELNKIYKEYE-CILN----QDL-LEHVQKVFQKQESTEEMFH 617

  Fly  1309 SSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPG-WNGTSKDLYSPEAES 1372
            ..:.....|....             ..|..|.....|.:|....|:|| |.       |.|..|
  Rat   618 RRQASLKKLAAKQ-------------TRPVQPVAPRPEALTKSPSPSPGSWR-------SSENSS 662

  Fly  1373 SPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTS 1437
            |.                   |..:..|     |..|..|       :.:|....::|.||....
  Rat   663 SE-------------------GNALRRG-----PYRRAKS-------EMSEPRQGRTSSTGEEEE 696

  Fly  1438 SVSTTALTPSRQLTDAEKLRKVVM-ELVDTERTYVKHLNNLLEHYLEPMKR-------ETFLSNA 1494
            |::.              ||:.|| ||:||||.||:.|..:||.|...|..       .|.|.|.
  Rat   697 SLAI--------------LRRHVMNELLDTERAYVEELLCVLEGYAAEMDNPLMAHLISTGLQNK 747

  Fly  1495 EINALFGNIHEIVTF-QRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYS 1558
            : |.||||:.||..| .|.||:.||..:|          |.:.      :|..||..:..|::|.
  Rat   748 K-NILFGNMEEIYHFHNRIFLRELESCID----------CPEL------VGRCFLERMEEFQIYE 795

  Fly  1559 SFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTD 1623
            .:|.:..:::.:..........||.    ..|..|..:|:|||:||:|||.||.|||::|     
  Rat   796 KYCQNKPRSESLWRQCSDCPFFQEC----QKKLDHKLSLDSYLLKPVQRITKYQLLLKEM----- 851

  Fly  1624 TRADEHVH----LCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGD--- 1681
            .:..:|..    |.|||..:..:.:.:|:...:....|                 .|.:.||   
  Rat   852 LKYSKHCEGAEDLQEALSSILGILKAVNDSMHLIAITG-----------------YDGNLGDLGK 899

  Fly  1682 LLYYGGVE-WLNISDFLGKIK-----KGLELHAMCFVFKSAVVFLCKERLRQ---KKKLMGVSSK 1737
            ||..|... |.:......|:|     |.::.|  .|:.:.||:| ||:|...   .:|....|.|
  Rat   900 LLMQGSFSVWTDHKKGHTKVKELARFKPMQRH--LFLHEKAVLF-CKKREENGEGYEKAPSYSYK 961

  Fly  1738 NATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNA 1802
            .:.|            :|.|.:..:...|.....:|         ....|:||::...|.:.:.|
  Rat   962 QSLN------------MTAVGITENVKGDTKKFEIW---------YNAREEVYIIQAPTPEIKAA 1005

  Fly  1803 FLKTIRQII-------RESVRNM------SIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLER 1854
            ::..||:::       ||:.::.      |:|:.....:|           .:.|...|.:.||.
  Rat  1006 WVNEIRKVLTSQLQACREASQHRALEQSHSLPLPTPASTS-----------PTKGSTRNVKKLED 1059

  Fly  1855 PKQQITIVHG--SHTLGKPKKK-------SGSQRHSAGNIDYDNLSG-----SQEADDLPPSVGV 1905
            .|.....:.|  |.:|.||.:|       |.:...||.:.....|.|     .|:|....|.   
  Rat  1060 RKTDPLCLEGCVSSSLPKPPEKGKDDAVPSSTSESSALSRKRFTLQGLANLKGQKASPTSPD--- 1121

  Fly  1906 VHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPH 1970
             ..|..|.......|.|.||.|||                                         
  Rat  1122 -KKAKRHEVKSDPTPFGLRGWSKT----------------------------------------- 1144

  Fly  1971 PHPREPPPPPIRQPHLHHHSSDIERIDPG--------TKSEGEEDSQQGTIRPKATLGRTPNHLT 2027
                             .||.:....|.|        ..|:.|||   |.:.|:..:   |...|
  Rat  1145 -----------------SHSLEAPEEDGGWSSAEELINSSDAEED---GGVGPRKLV---PGKYT 1186

  Fly  2028 L------STTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAA 2086
            :      ..:.||::.| |....:::.......|    ::||..        ..|..|.|:.:|.
  Rat  1187 VLMDGEKGGSDTLAMRS-GDMVEVVEEGTEGLWY----VRDLTS--------SKEGWVPASSLAT 1238

  Fly  2087 SFNLSLGSSGS---LFASDARDNQTQSRTQSQIHSLHPSP 2123
                .||.|.|   |.:||:..........|.....:|:|
  Rat  1239 ----LLGKSSSAQCLSSSDSSPGSAVLSNSSSCSEGYPTP 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 22/142 (15%)
PH 873..974 CDD:278594 15/116 (13%)
TIAM1_RBD 1141..1219 CDD:176413 15/86 (17%)
PDZ_signaling 1221..1308 CDD:238492 16/97 (16%)
RhoGEF 1456..1647 CDD:238091 65/203 (32%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/197 (19%)
PH 1693..1812 CDD:278594 26/133 (20%)
Mcf2lXP_006253478.1 SEC14 145..290 CDD:214706 26/174 (15%)
SPEC 421..623 CDD:238103 41/238 (17%)
RhoGEF 702..879 CDD:238091 64/202 (32%)
PH_Dbs 886..1017 CDD:269934 34/171 (20%)
PH 900..1014 CDD:278594 30/137 (22%)
SH3_DBS 1184..1236 CDD:212791 11/64 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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