DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Arhgef7

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_008769601.2	Gene:	Arhgef7 / 114559	RGDID:	620624	Length:	930	Species:	Rattus norvegicus

Alignment Length:	867	Identity:	178/867 - (20%)
Similarity:	297/867 - (34%)	Gaps:	259/867 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1399 GGLGVAKPTSRTSSFEIENL--LKTAEQE------TRKSSPTGSVTSSVSTTALTPSRQLTDAEK 1455
            ||........||..|....:  :|.:|:.      |.||.|.|     ..|||:..|       .
  Rat   266 GGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKG-----FDTTAINKS-------Y 318

  Fly  1456 LRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEES 1520
            ...|:..:::||..|.|.|.::|..||.|::....||:|..:.|.||:.||.:||:..:|:|||
  Rat   319 YNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEE- 382

  Fly  1521 LDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEFL 1584
                        |.:.......:|..||..:...: ||.::||:|..|..||  .|.:..|.||:
  Rat   383 ------------CTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVL--TEHSEDLGEFM 433

  Fly  1585 AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQM-RNLTDTRADEHVHLCEALKGMEKVAEHINE 1648
            ..:.........|.:.|.||..|:.|||.||::: |::.|...|.. .:.:::...:.::....|
  Rat   434 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQ-DIQKSMTAFKNLSAQCQE 497

  Fly  1649 MQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVF 1713
            :::..|           ...:...:||....||.:           ..||.:           .:
  Rat   498 VRKRKE-----------LELQILTEPIRSWEGDDI-----------KTLGSV-----------TY 529

  Fly  1714 KSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHL 1778
            .|.|...|          .|...||.       ||.:|.|...:.:.||...   |.|:::
  Rat   530 MSQVTIQC----------AGSEEKNE-------RYLLLFPNLLLMLSASPRM---SGFIYQ---- 570

  Fly  1779 RSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGS------VSGHSS 1837
             .:|......:..|.:| .:.||||     :|                  |||      ||.::.
  Rat   571 -GKLPTTGMTITKLEDS-ENHRNAF-----EI------------------SGSMIERILVSCNNQ 610

  Fly  1838 QGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPS 1902
            |.:        .:.:|..::|..:...|:...||        ||.                  ||
  Rat   611 QDL--------HEWVEHLQRQTKVTSVSNPTIKP--------HSV------------------PS 641

  Fly  1903 VGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHP 1967
                |....|    .:.|:.....||.|. :|....:.|.|..                  |..|
  Rat   642 ----HTLPSH----PLTPSSKHADSKPVA-LTPAYHTLPHPSH------------------HGTP 679

  Fly  1968 H------PHPHPREP---------PPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKA 2017
            |      |...|:.|         |.||:|......:..|:.| .|.|..:         :.||.
  Rat   680 HTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSR-SPKTMKK---------LLPKR 734

  Fly  2018 TLGRTPNHLTLSTT-STLSVGSTGSQARLIQSSHPPASYQPV---------LMKDLGKPSPDESE 2072
            ...|.|:....:.| ||.::.......::|::....|..:..         ||.:......|:|.
  Rat   735 KPERKPSDEEFAVTKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSS 799

  Fly  2073 LESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQS--- 2134
            |:                |||...||...:..|....|...| :.:.|.....|..:|.::|
  Rat   800 LD----------------SLGRRSSLSRLEPSDLSEDSEYDS-LWTAHSYRMGSASRSRKESAPQ 847

  Fly  2135 ---PKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMDK 2196
               |:::..::|..:|..:.:...:.:........|:.:|.  :|...:.:...|.:..||
  Rat   848 VLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQEL--RQDNKKMKKSLEEEQRAR---- 906

  Fly  2197 HLSDLEQ------ENLTDGTCD 2212
              .|||:      :|:.|...|
  Rat   907 --KDLEKLVRKVLKNMNDPAWD 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	53/192 (28%)
		PH2_Tiam1_2	1650..1823	CDD:269957	29/172 (17%)
		PH	1693..1812	CDD:278594	24/118 (20%)
Arhgef7	XP_008769601.2	CH_betaPIX	71..183	CDD:409115
		RhoGEF67_u1	185..231	CDD:406911
		SH3_betaPIX	235..288	CDD:212994	5/21 (24%)
		RhoGEF	319..496	CDD:238091	53/192 (28%)
		PH_Cool_Pix	527..625	CDD:269932	30/165 (18%)
		RhoGEF67_u2	681..779	CDD:374671	20/107 (19%)
		betaPIX_CC	841..927	CDD:406829	16/94 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910