Protein Alignment sif and Prex2

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_006495504.1
• Gene: Prex2 / 109294
• MGIID: 1923385
• Length: 1617
• Species: Mus musculus
• Alignment Length: 508
• Identity: 126/508 - (24%)
• Similarity: 218/508 - (42%)
• Gaps: 100/508 - (19%)

  Fly  1447 SRQLTDAEKLRKVVM-ELVDTERTYVKHLNNLLEHYLEPM------KRETFLSNAEINALFGNIH 1504
            :|::....:||..|: ||..|||.||..|..|:..:|..|      |.:..::...:..||.||.
Mouse     6 AREVDKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKVDKNVTEETVKMLFSNIE 70

  Fly  1505 EIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQK 1569
            ||:...::||:.:||.|..||...:            .:|:.||::.:.|::|..:|::|.||||
Mouse    71 EILIVHKEFLKVVEECLYPEPSAQQ------------EVGACFLHFKDKFRIYDEYCSNHEKAQK 123

  Fly  1570 VLHPNEGNHALQEFL---AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVH 1631
            :|........::.||   .....::.....||.||:.|||||.||||||:::...|..|..::..
Mouse   124 LLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRRHSDYTA 188

  Fly  1632 LCEALKGMEKVAEHINEMQR------IHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEW 1690
            :.|||:.|:.|..:|||.:|      :.||:.|                         :..|.|.
Mouse   189 VMEALQAMKAVCSNINEAKRQMEKLEVLEEWQA-------------------------HIEGWEG 228

  Fly  1691 LNISD---------FLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVE-I 1745
            .||:|         .|.||..|.....:.|:|.:.:|: ||.:.|:.|     :||.:|:... :
Mouse   229 SNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVY-CKRKHRRLK-----NSKASTDGYRYV 287

  Fly  1746 IRYQVLIPVTEVQVRASSAKDMDS--HFL---WELIHLRSQLQRRSEKVYVLSNSTADFRNAFLK 1805
            .|.::...|.||:.......|..|  |.:   |: ||     .....|.:|....:.:.::.:.:
Mouse   288 FRGRINTEVMEVENVDDGTADFHSSGHIVVNGWK-IH-----NTAKNKWFVCMAKSPEEKHEWFE 346

  Fly  1806 TIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGK 1870
            .|.: .||..:.:.:.|:.......|..|.....|  |...||  .::..|:::|..
Mouse   347 AILK-ERERRKGLKLGMEQDTWVMISEQGEKLYKM--MCKQGN--LIKDRKRKLTTF-------- 398

  Fly  1871 PKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSV---GVVHYASGHTHGQQMQP 1920
            ||...||: ..:..::...:...:|...|..::   |::|:.   |...|.:|
Mouse   399 PKCFLGSE-FVSWLLEIGEIHRPEEGVHLGQALLENGIIHHV---TDKHQFKP 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	64/200 (32%)
		PH2_Tiam1_2	1650..1823	CDD:269957	38/193 (20%)
		PH	1693..1812	CDD:278594	29/133 (22%)
Prex2	XP_006495504.1	RhoGEF	19..204	CDD:366202	62/196 (32%)
		PH_Collybistin_ASEF	210..356	CDD:269931	37/183 (20%)
		DEP_1_P-Rex	374..454	CDD:239886	18/90 (20%)
		DEP_2_P-Rex	466..558	CDD:239887
		PDZ_signaling	587..662	CDD:238492
		PDZ_signaling	669..736	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810