| Sequence 1: | NP_001261446.1 | Gene: | sif / 43892 | FlyBaseID: | FBgn0085447 | Length: | 2734 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_006104.4 | Gene: | VAV3 / 10451 | HGNCID: | 12659 | Length: | 847 | Species: | Homo sapiens |
| Alignment Length: | 578 | Identity: | 127/578 - (21%) |
|---|---|---|---|
| Similarity: | 222/578 - (38%) | Gaps: | 164/578 - (28%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
Fly 1481 YLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGS 1545
Fly 1546 AFLYYVNHFKLYSSFCASHSKAQKVLH-----PNEGNHALQE-FLAARNPKQQHSSTLESYLIKP 1604
Fly 1605 IQRILKYPLLLQQM-RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQ 1668
Fly 1669 KSCK---QPIDL---SPGDLLYYGGVEWLNISDFLGKIK-KGLELHAM----CFVFKSAVVFLCK 1722
Fly 1723 ER--LRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQ---- 1781
Fly 1782 -------LQRR--SEKVYVLSN-----STADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSV 1832
Fly 1833 SGHSSQG--MGSMGYPGNSQTLERPKQQITIVHGSH-TLGKPKKKSGSQRHSAGNID-------- 1886
Fly 1887 YDNLSGSQEADDLPPSV-----------GVVHYASGHTHGQQMQPAGFRGRSKTVGDV 1933 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| sif | NP_001261446.1 | WH1 | 35..144 | CDD:214674 | |
| PH1_Tiam1_2 | 860..985 | CDD:269937 | |||
| PH | 873..974 | CDD:278594 | |||
| TIAM1_RBD | 1141..1219 | CDD:176413 | |||
| PDZ_signaling | 1221..1308 | CDD:238492 | |||
| RhoGEF | 1456..1647 | CDD:238091 | 54/197 (27%) | ||
| PH2_Tiam1_2 | 1650..1823 | CDD:269957 | 38/203 (19%) | ||
| PH | 1693..1812 | CDD:278594 | 25/143 (17%) | ||
| VAV3 | NP_006104.4 | CAMSAP_CH | 18..103 | CDD:288798 | |
| RhoGEF | 193..369 | CDD:238091 | 55/217 (25%) | ||
| PH_Vav | 383..506 | CDD:269930 | 31/156 (20%) | ||
| PH | 407..502 | CDD:278594 | 19/112 (17%) | ||
| C1 | 514..561 | CDD:237996 | 9/58 (16%) | ||
| Sufficient for interaction with ROS1. /evidence=ECO:0000269|PubMed:11094073 | 560..847 | 20/98 (20%) | |||
| SH3_VAV3_1 | 596..657 | CDD:212914 | 13/62 (21%) | ||
| SH2_Vav3 | 666..768 | CDD:198270 | |||
| SH3_VAV3_2 | 791..846 | CDD:212911 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1291 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.940 | |||||