DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and LOC101886482

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_009292814.1 Gene:LOC101886482 / 101886482 -ID:- Length:1570 Species:Danio rerio


Alignment Length:1711 Identity:466/1711 - (27%)
Similarity:746/1711 - (43%) Gaps:422/1711 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   462 MGRASSQSSRF-----------------------------SGSRSSHEIGRGYPP-RNLYLELER 496
            ||.:.||.|.|                             |.|.|.::...|:.| :|....:.|
Zfish     1 MGNSDSQYSSFILPGKGKSSSLKLHNPKEDVVSPQSWWRNSDSTSGYKAKNGFSPHKNHQPYMSR 65

  Fly   497 ERSCI-EGSPPS---------DNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPP 551
            ...|| |||...         ||::|....:..             .|.||....|.|.:.....
Zfish    66 RYDCIKEGSSDKICAESHQDYDNILFQGNGFFV-------------GYRQQSGGLQAPMRNPSSE 117

  Fly   552 QRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEA--LLSQSMEN 614
            .:.|:               .||...|..:..:.:..|.|:.......||.|..:  :..|...|
Zfish   118 CKDSK---------------SSPKVLLRDDGSLRVEFTNARREPDVELSLGTRRSGPVDGQRASN 167

  Fly   615 LEFAESL--PGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERE 677
               ..||  .||...||:      ...:.|       ...:....:..|....|:..:.     .
Zfish   168 ---GSSLGSEGSWYDSPW------GNGTDL-------CDNVFSNSQPSDNSSGYTTLSS-----T 211

  Fly   678 RERDRGYLSDHNSSFSNSRCASCIGE-SARAQWFRHSDGWRSGSSTIGSGSGHG----------- 730
            |..|.||.:.:|:..|....:|...: :.....:.:||. .|..:.:...||.|           
Zfish   212 RTVDFGYFNGYNTEQSEHHTSSLTCQTTVHGGQYANSDS-NSNGNRVEEDSGIGDSVLLHLENNG 275

  Fly   731 -------------------MMTQQIPGSGH-KRSPWDSLPSLRQDSSLNDSGYKS---------- 765
                               :||.|...|.| :.|...||.:..||.:.....|.|          
Zfish   276 LPEQYTNPNMTLPFPTVGILMTDQFKDSPHLQASLTSSLDANSQDENQETRLYTSQTLPCRKAVP 340

  Fly   766 ---ARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLT 827
               .|.|||:.|   ||:.|..:..||.::.|....|:.|||..:   |   .:|.:.::.....
Zfish   341 DGNTRKDSLKSR---IRRLSDWTGSLSRKKRRLQDPQEPSIEVVN---C---GAEGTVEESRPFW 396

  Fly   828 TAVSDEDDGESVMASPY----------------------KAKATGTA-----------ASSFNC- 858
            ..:|.:...:|.::.|:                      .|.:|||.           :||.:. 
Zfish   397 NPMSCQTQLDSTLSGPFGQQNQGATLRQNIYENFMQGLETASSTGTVDGLQIWEAEGESSSGSMG 461

  Fly   859 ------------TGAVRKAGFLSVKKWL-LRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSRE 910
                        .|.||:||:|:.|..: |.|..::||..:|.|:.|||.|||.|||....:.:.
Zfish   462 SIEQMDFLFEKEQGVVRRAGWLAFKPLITLHKDRKLELVTRRKWRQYWVTLKGCTLLLGESNGKT 526

  Fly   911 GRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAA 975
            ....|..|::.::.:.:|:|.:|||||::.:||||.|:||.|||||..|.:|||||.:||||.|:
Zfish   527 SPEQECTPRYAVLAEDSIVQAVPEHPKKENVFCLSNAYGDVYLFQAENQTDLENWVTAIHSASAS 591

  Fly   976 AFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLER 1040
            ..|:.:||..||.||:.:...|.:.|:.|.|:|.|||||.||::||:.|..|::||||||:|||:
Zfish   592 HLAKRQGKEDTLRLLKNQSRSLLQKIDMDDKMKKMAELQLSVISDQKNRKAIESQILQWEQNLEK 656

  Fly  1041 LHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLL 1105
            .:.|.||:|||:||||..|||||||||....||:|..|.:||:|:||||||.||.|..:.|....
Zfish   657 FNLELFRMRCYLASLQGTELPNPKSLLATAGRPSKMALGRLGIFSVSSFHALICNRDEATLKRRS 721

  Fly  1106 AG--RGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFK------------------------- 1143
            ..  ||...:|..:.|......|........|....:.|:                         
Zfish   722 RSHPRGVRNKRGLLFSSQKGLDSLTKRNREKRQSMSQIFEGYSSGSFGHPSTQSSSERLDIFTKP 786

  Fly  1144 --------------------VAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRR 1188
                                |..||....:|.::....|.:.|..||..::|:|..|.:.:::..
Zfish   787 HAAAPPDGHLWDCSLESLVFVLAPDGQIISVPIKHDSLVSDVLTLACKAKHLDPALHVLHMRRHL 851

  Fly  1189 DMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDEL 1253
            . :|.....|...||::..:::.  :||....:..:.:.|......:||:|... ::.:.|..  
Zfish   852 G-QDVERITPAPTDLLKTLVYDE--LEVWPINVLSLTMSRPDATIDFGFAVTGH-VDGSRRTH-- 910

  Fly  1254 CCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEP---- 1314
             .|||.|:.:.:|..:|:..||||:.:||..|:.||:..::|.. .:|.|::::|.....|    
Zfish   911 -VYVSEVKPEGLAYIHGLRAGDEILTLNGVSVTSLDLGLMQSFF-SQQELNLVLRREENSPDQQS 973

  Fly  1315 ---PDLVGIMRVTDDMIDSLVCPP-----PPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAE 1371
               ||                |.|     |.||  :..|::.|                     :
Zfish   974 SVWPD----------------CEPDQAQHPHTD--IHLEQLST---------------------D 999

  Fly  1372 SSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETR--------- 1427
            ......|.:.:.::|                                |:.||::.:         
Zfish  1000 QCQEQEFGEGSGVSA--------------------------------LEEAERDRKNPETVCKLY 1032

  Fly  1428 KSSPTGSVT---------SSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLE 1483
            ::.|.|.|.         |:.:|.|.:..|.::..|:||.|:.||||||::|||.|.:|.|.||:
Zfish  1033 QTLPEGPVLMVEGHKNPYSAENTRARSSPRHMSVTERLRMVIQELVDTEKSYVKDLGSLFEIYLK 1097

  Fly  1484 PMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFL 1548
            |::||||||:.|:.:|||::.|::.|||.|||.||:.....||::..:...:.:.:||::|.:||
Zfish  1098 PLQRETFLSHDEMESLFGSLPEMLDFQRVFLQTLEDRTTSSPDYHALDCPEKLKKLLFSLGGSFL 1162

  Fly  1549 YYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPL 1613
            ||.:||||||.|||:|.|.||||...:.:.|.:|||.||||.:|||||||||||||:||:|||||
Zfish  1163 YYADHFKLYSGFCANHIKVQKVLERAKTDRAFKEFLEARNPTKQHSSTLESYLIKPVQRVLKYPL 1227

  Fly  1614 LLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLS 1678
            ||:::.:|||..:|:|.||.||||.|||||.||||||:|:|:||.:||.|..:.....|:..::|
Zfish  1228 LLRELVSLTDPESDQHNHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGPEKEVTEIS 1292

  Fly  1679 PGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEV 1743
            ..:.:.:....|.|....||:::|..||  ..|:||.|::.:.:|. :.||::     .:...::
Zfish  1293 MSEFIIHSTALWQNPLPSLGRMRKDPEL--TLFLFKKALILVYRES-KLKKRM-----TSRLGDL 1349

  Fly  1744 EIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIR 1808
            :..:::.||||:.:|||..::...::..:||::|.:|:::.|.|..:.|.:|..:.:.:.::.||
Zfish  1350 DPFKFRWLIPVSSLQVRPGTSAGSENPCVWEVVHTKSEVEGRPEMFFQLCSSNLENKASAVRAIR 1414

  Fly  1809 QIIRESVR--------------NMSIPMKNFGG----------------------SSGSVSGHSS 1837
            .::||:.:              |.:.|.::..|                      |...:..||.
Zfish  1415 NLLRENAKRIAPVERRLRDFNSNFTFPRRSHPGALRSHSWQRPPDSPKLPEGYAHSEPPIPNHSL 1479

  Fly  1838 QGMGSMGYPGNSQT--------LERPKQQITIVHGSHTLGKPKKK--SGSQRH------------ 1880
            :......:..:.::        ||...|::..|..:..:.|..::  ..|..|            
Zfish  1480 RASREQSHNASKRSTLCSLTSALEAQLQRLNFVDEAQGMSKSSQQLDDSSGLHLNSLLVRDYSVQ 1544

  Fly  1881 SAGNI-----DYDNLSGSQEA 1896
            |.|::     .||.|.|.|:|
Zfish  1545 SLGSVVGEDCFYDTLMGIQKA 1565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 57/125 (46%)
PH 873..974 CDD:278594 46/101 (46%)
TIAM1_RBD 1141..1219 CDD:176413 18/122 (15%)
PDZ_signaling 1221..1308 CDD:238492 23/86 (27%)
RhoGEF 1456..1647 CDD:238091 108/190 (57%)
PH2_Tiam1_2 1650..1823 CDD:269957 45/186 (24%)
PH 1693..1812 CDD:278594 29/118 (25%)
LOC101886482XP_009292814.1 PH1_Tiam1_2 475..601 CDD:269937 57/125 (46%)
UBQ 806..878 CDD:320785 17/74 (23%)
PDZ_signaling 890..963 CDD:238492 22/77 (29%)
RhoGEF 1073..1262 CDD:214619 107/188 (57%)
PH-like 1264..1423 CDD:327399 43/166 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 233 1.000 Domainoid score I2328
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002962
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.910

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