DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and LOC101886286

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_005169554.1	Gene:	LOC101886286 / 101886286	-ID:	-	Length:	297	Species:	Danio rerio

Alignment Length:	312	Identity:	77/312 - (24%)
Similarity:	123/312 - (39%)	Gaps:	60/312 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   859 TGAVRKAGFLSVKK-WLLRKKH-QIELAR----KRGWKGYWVCLKGTTLLFYPCDSREGRSV-EA 916
            :|.|..:|.|..|. :|:||.| ..:..|    |||||.::..|||..|.....:.|..:.: :.
Zfish     3 SGFVPASGALLYKMGFLVRKVHADCDGKRTPRGKRGWKTFYAVLKGLILYLQKGEYRPDKQLSDE 67

  Fly   917 APKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHR 981
            ..|:.:.:..::.....::.||..:|.|.||....||||||...::::|:..|::. ||.|:..
Zfish    68 DLKNAVSIHHSLAIRATDYSKRPNVFYLRTADWRVYLFQAPNAEQMQSWITRINTV-AAMFSAP- 130

  Fly   982 GKTGTLHLLQEEIFRLEKAIESDHKLKH------MAEL-QQSVVTDQETR-HQIQTQILQW---- 1034
                          .|..||.|..|...      .::| |:..|...||| ..|.|::.|.
Zfish   131 --------------PLPAAIGSQKKFSRPLLPGSASKLSQEEQVQAHETRFRSISTELAQLRSYP 181

  Fly  1035 -EENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFI----- 1093
             :..::....|::|||......:.........||        ....:.|...:|.|.|.:
Zfish   182 PDRKVKGRELEEYRLREEYLEFEKTRYETYSMLL--------RAKQRCGDDDLSVFEAMLLEEGA 238

  Fly  1094 ---CARSPSLLNNLL-------AGRGATKRRPPMLS-RSNSGSSRRSMQMNS 1134
               ...||:|.::.|       |....|...||..| ..|:|.||...|.:|
Zfish   239 LQRAQSSPTLQDSSLTCSTRDGASPSTTTAAPPEPSGNGNNGCSRGQGQRHS 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	38/131 (29%)
		PH	873..974	CDD:278594	30/106 (28%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
LOC101886286	XP_005169554.1	PH_EFA6	11..133	CDD:270107	35/137 (26%)
LOC101886286	XP_005169554.1	PH	13..121	CDD:278594	30/107 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910