DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and arhgef37

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_005173214.1	Gene:	arhgef37 / 101883655	ZFINID:	ZDB-GENE-100514-3	Length:	709	Species:	Danio rerio

Alignment Length:	763	Identity:	145/763 - (19%)
Similarity:	262/763 - (34%)	Gaps:	188/763 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1414 EIENLL-KTAEQETRKSSPTGSVTS-SVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHL-- 1474
            |:||.| :.||:|..|......|.: ..:.......|||...|       |:|.||:.|:|||
Zfish    22 EMENALEELAEEEEDKEERKARVAAEEAAARERAAQRQLMAIE-------EMVHTEKNYLKHLQI 79

  Fly  1475 -----NNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEH-C 1533
                 |:.|:....|...   |.|     :|.:|.|::....:.|..|:::.....|....|. |
Zfish    80 CTVTINSNLQKLQPPPPN---LEN-----MFQHIDEVMEVSSRLLSLLDQAQMQHSDPKYLETLC 136

  Fly  1534 GQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLE 1598
            ..|.::...|..|:..|:.::...::...|:.:.:.:.      ..:...:.:..| ..::|||.
Zfish   137 DSFLSLSQDIEMAYKEYLANYNNITALENSYKQKEALW------MEMVRIIKSSAP-DVNASTLS 194

  Fly  1599 SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHE--------E 1655
            .:|:.|:|||.:||||.|.::..||.:...:..|........::...|||.:|..|        |
Zfish   195 FFLVMPVQRIARYPLLFQTIQKHTDPQHPAYPELEHTAHTAIQINCRINEYKRFREVADKYKKTE 259

  Fly  1656 YGAIFDHLFRQHQKSC-------KQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGL-ELHAMCFV 1712
            ...|.|.|.|....|.       .|.|....|.:......|:..::.|...:::|: |||.....
Zfish   260 NLTIKDKLNRLSGHSIAKKTARFSQYIKHETGIVPKLKDEEFDALAGFFFVLERGVSELHDNLLT 324

  Fly  1713 FKSAVV-FLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELI 1776
            :...:. ||..........|.|..:...:.|:.:...|.:.|..|.:::....|.:.|  |.||:
Zfish   325 YLHHLQRFLSCRPEEADLDLEGEKTALFSKEITVALRQWIYPSYEKRLKTLVFKPLSS--LRELM 387

  Fly  1777 -HLRSQLQRRSEKV----------------YVLSNSTADFRNAFLKTIRQIIRESV--------- 1815
             ..|:.:::|.:|:                ..::|:........|..:.|...:::
Zfish   388 AGPRNLIRKRQDKLLDYEPIEEKSNLTFEEQAIANTYKTMNTLLLNELPQFNGKALQLMWAALEA 452

  Fly  1816 -----RNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLE------------RPKQQITIVH 1863
                 |:::..|:....|......||....|.......:..||            :.:....||.
Zfish   453 FSVLQRDLATDMEQLATSFTHQLPHSYLEAGDFWKWAETSVLEGSWRMESLCRSVQDELNAPIVQ 517

  Fly  1864 GSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSK 1928
            ..:|:.|.:....:..|           ||::...|...|                 .|.|....
Zfish   518 ALNTVSKKRLMYLNANH-----------GSEKIYQLTGPV-----------------VGTRDLDL 554

  Fly  1929 TV--GDVTEITCSSPEPHQQQQQQQQQQQQLMQ----QGHAHAHPHPHPHPREPPPPPIRQPHLH 1987
            |:  |::..:.|       :...:..:::.|:.    :|:..|......|.....||  :.|||
Zfish   555 TLNKGELVAVVC-------EMDTRGDRRRWLVDAGGPRGYVPASKLARYHQLTIDPP--QSPHL- 609

  Fly  1988 HHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGS-------------- 2038
                ::....||.:            |...|.|..| |||..||....|.:
Zfish   610 ----NVTPTGPGPR------------RHSYTPGAQP-HLTTITTPCFQVYAGYDFTARSAHELSL 657

  Fly  2039 -TGSQARLI------------------QSSHPPASYQPVLMKDLGKPS 2067
             .|...|::                  |..:.|::|..:|...:..|:
Zfish   658 RAGEPVRVVEPHDKRGNKEWSLVEARGQRGYVPSNYLTLLPSVIASPT 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	43/198 (22%)
		PH2_Tiam1_2	1650..1823	CDD:269957	37/220 (17%)
		PH	1693..1812	CDD:278594	24/137 (18%)
arhgef37	XP_005173214.1	RhoGEF	62..243	CDD:306973	44/202 (22%)
		BAR_DNMBP	295..481	CDD:153273	30/187 (16%)
		SH3	539..592	CDD:327375	10/76 (13%)
		SH3	640..694	CDD:327375	5/53 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3224
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840