Protein Alignment sif and sos2

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_002938172.3
• Gene: sos2 / 100497015
• XenbaseID: XB-GENE-1006170
• Length: 1333
• Species: Xenopus tropicalis
• Alignment Length: 1104
• Identity: 203/1104 - (18%)
• Similarity: 356/1104 - (32%)
• Gaps: 324/1104 - (29%)

  Fly  1130 MQMNSRD-EPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDH 1193
            :|..|.| |..:..|.|:      |..|....|:|........||  .|.|...|:..|: |...
 Frog   359 LQERSEDQEDRECLKQAI------TALLNLRCSMERIFNKHSPRR--RPGEPIWRLYNRQ-MRSK 414

  Fly  1194 NYFVPHRNDLIENY--LHNHEFVEVCMKILYQVELQRTTLEQ------MWGFSVEAELIENAER- 1249
            :..:...|::.:|.  ....:..:.|.:.:.:..|.|...:.      ..|..:..::.....|
 Frog   415 HVAIKKMNEIQKNIDSWEGKDIGQCCNEFIMEGSLTRVGAKHERHIFLFDGLMISCKMNHGQSRI 479

  Fly  1250 ----------QDELCCYVSRVEDK--SVAMHNG--IIKGDEIMVINGAIVSDLDMMYLESVLQEE 1300
                      :::|.....::.||  :....|.  ::..||..::..|..::....::.::
 Frog   480 PGYNTAEYRLKEKLIMRKVQINDKEDTSEYKNAFELLSKDENSIVFAAKTAEEKNNWMAAL---- 540

  Fly  1301 QSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDL 1365
              :|:..||             :.|.|:|::          ::.||....|.:|:|       |:
 Frog   541 --ISLQYRS-------------MLDRMLDTV----------LIQEENEQPLRLPSP-------DV 573

  Fly  1366 YS-PEAESSPATSFVDPAAMAAQLAVGGVGGV-VVGGLGVAKPTSRTS----------------- 1411
            |. .|.:|.....|.|        :|....|: ::.|..|.|...|.:
 Frog   574 YRFVEEDSEENIVFED--------SVQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTY 630

  Fly  1412 -SF----EIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEK--LRKVVMELVDTERT 1469
             ||    |:.||| ....|.....||.|...::.......|..|....|  ::.|.:.:::..|.
 Frog   631 RSFCKPQELLNLL-IERFEIPDPEPTESDKMAIEKGEQPISANLKRFRKEYVQPVQLRVLNVFRH 694

  Fly  1470 YVKHLNNLLEHYLEPMKR-ETFLSNAEINAL---FGNIHEIVTFQRQFLQN-LEESLDLEPDFNK 1529
            :|:|.....|..||.:.| |:|:||....::   ..:|.:|:..::|...| :..::..|..|..
 Frog   695 WVEHHFYDFERDLELLDRLESFISNVRGKSMKKWVESIAKIIRRKKQAQANGVSHNITFESPFPP 759

  Fly  1530 FE----HCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPK 1590
            .|    ..||...               |.|.:            |||.|....|
 Frog   760 IEWHISRTGQCET---------------FDLMT------------LHPIEIARQL---------- 787

  Fly  1591 QQHSSTLESYLIKPIQ-------------RILKYPLLLQQMRNLTD------------TRADEHV 1630
                :.:||.|.:.:|             :.:..|.||:.:|:.|:            ...:|.|
 Frog   788 ----TLMESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCLVETENFEERV 848

  Fly  1631 HLCEALKGMEKVAEHINEMQRIHEEYGAI-------FDHLFRQHQKSCKQPIDLSPGDLLYYGGV 1688
            .:...:..:.:|.:.:|....:.|...|:       .||.|...|:..|:.:|
 Frog   849 AVFSRIIEILQVFQELNNFNGVLEIVSAVNSVPVYRLDHTFEALQERKKKILD------------ 901

  Fly  1689 EWLNISD-----FLGKIKKGLELHAMCFVFKSAVV------------FLCKERLRQKKKLMGVSS 1736
            |.:.:|.     :|.|:|   .::..|..|....:            ||    .||.|:|:..|.
 Frog   902 EAVELSQDHFKKYLAKLK---SINPPCVPFFGIYLTNILKTEEGNPDFL----KRQGKELINFSK 959

  Fly  1737 KNATNEV--EIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSN-STAD 1798
            :....|:  ||.:||                  :..:   .:...:.:||..|.:..:.| ...:
 Frog   960 RRKVAEITGEIQQYQ------------------NQPY---CLRTEADIQRFFENLNPIGNFGEKE 1003

  Fly  1799 FRNAFLKTIRQIIRESVRNMSIPMK-----NFGGSSGSVSGHSSQGMGSMG-YPGNSQTLERPKQ 1857
            |.:......::|   ..||...|.:     .:...|..:..:|.:.:.|.| ..|:...|||...
 Frog  1004 FTDYLFNKSQEI---EPRNCKQPPRFSRKTTYSLKSPGIRPNSGRHLSSSGTLRGHPMPLEREPY 1065

  Fly  1858 QIT---IVHGSH-----------TLGKPKKKSGSQRHSAGNIDYDNLSGSQ---------EADDL 1899
            :|:   |....|           |...|...:.|:.....::|..:..||.         .:...
 Frog  1066 KISFSRITESDHESTISPPISPNTPSTPPASASSELSVFVDLDLHSSFGSSTMLSHGFLPNSKSF 1130

  Fly  1900 PPSVGVVHYASGH-------THGQQMQPAGFR--GRSKTVGDVTEITCSSPEPHQQQQQQQQQQQ 1955
            ..|.|.:|..|..       ...:::.|.|..  |.||...|...|....|.|.:.|.:......
 Frog  1131 FSSCGSLHRLSEEPLLPPPLPPRRKVDPEGSNLVGHSKLDDDPPAIPPRLPPPPKIQPRVPAYTG 1195

  Fly  1956 QLMQQGHAHAHPHPHPH---PREPPPPPIRQP----------------HLHHHSSDIERIDPGTK 2001
            ..  .|..|:.|.|.|.   |..|||.|.|.|                .||........::....
 Frog  1196 PF--DGPLHSPPPPPPRDPIPDTPPPVPQRPPEHFINCPLNLQPPPLGRLHREQDWFREVNTAPN 1258

  Fly  2002 SEGEEDSQQGTIRPKA---TLGRTPNHLTLS----------TTSTLSVGSTGSQARLIQSSHPP 2052
            |.....|   |..|:|   ..|.:.:|..||          ..|...:.....:....:.||||
 Frog  1259 SPNTPPS---TPSPRALRRCCGLSTSHSNLSHVLAPPVPPRQNSNPQLPKLPPKTYKREISHPP 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	16/79 (20%)
		PDZ_signaling	1221..1308	CDD:238492	12/107 (11%)
		RhoGEF	1456..1647	CDD:238091	40/224 (18%)
		PH2_Tiam1_2	1650..1823	CDD:269957	36/199 (18%)
		PH	1693..1812	CDD:278594	24/138 (17%)
sos2	XP_002938172.3	Histone	70..169	CDD:333859
		RhoGEF	200..382	CDD:238091	8/28 (29%)
		PH_SOS	438..544	CDD:269963	13/111 (12%)
		RasGEFN	596..740	CDD:214571	32/144 (22%)
		RasGEF	775..1014	CDD:238087	51/304 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910