DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and plekhg2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_002938639.3 Gene:plekhg2 / 100492670 XenbaseID:XB-GENE-6468886 Length:1982 Species:Xenopus tropicalis


Alignment Length:1524 Identity:308/1524 - (20%)
Similarity:514/1524 - (33%) Gaps:533/1524 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1343 MSEEMITGLIVPA--PGWN-GTSK-------DLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVV 1397
            :|:::..|...|.  |.|. |.::       .:..||..|..::......|.....:|..:.|:|
 Frog     4 VSKDVTLGNFQPGDLPAWPLGAAQIGARLHYKVTMPEGVSRGSSKRACKQAAPRPTSVSSLSGIV 68

  Fly  1398 VGGLGVA-----------KPTSRTSSFEIENLLKTAEQETRKS-SPTGSVTSSVSTTA------- 1443
            .|..|..           :|.|.:||....:|     |::..| ..:|::.||.:|.:       
 Frog    69 DGMSGSCTSVNTVCSDSDRPVSLSSSTSSASL-----QDSHSSFGSSGALVSSQNTGSCYTQQNG 128

  Fly  1444 ------LTPSRQLT-DAEK---------------LRK-------------VVMELVDTERTYVKH 1473
                  |||...|. ::|:               |||             ||:|:::||:.||:.
 Frog   129 SDISLDLTPVALLEGESERRAMDRPFLGYACSPILRKARDPKIKLSHVDRVVLEILETEQAYVRD 193

  Fly  1474 LNNLLEHYLE--------PMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKF 1530
            |.:::|.||.        |:|.|      :::.||.||.:|..|..:.|::|             
 Frog   194 LKSIVEDYLGCIIDCGHLPLKPE------QVSTLFCNIEDIYEFNSELLEDL------------- 239

  Fly  1531 EHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSS 1595
            |:|    |....|...|:.....|.:|:.:|.::..:..||.....:..|.:|...|.....||.
 Frog   240 ENC----NSAHGIAECFVMRSEDFDIYTLYCMNYPNSVSVLRECMKSEELVQFFRERQAILSHSL 300

  Fly  1596 TLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIF 1660
            .||:||:||:|||:||.||||::....|..|..:..:.||:..|..||.:||:|:|..|      
 Frog   301 PLETYLLKPVQRIMKYHLLLQELAKHFDKNAPGYEVVEEAIITMTAVAWYINDMKRKQE------ 359

  Fly  1661 DHLFR----QHQKSCKQPIDLSP-GDLLYYGGVE---------WLNISDFLGKIKKGLELHAMCF 1711
             |..|    |.|....|..|||. |:|:..|...         :...|..|...||.::|    |
 Frog   360 -HAVRLQEIQSQLVNWQGPDLSAFGELVLEGTFRVQRMKKERAFFLFSKMLLIAKKRMDL----F 419

  Fly  1712 VFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELI 1776
            ::|.. :|.|...|.:..| .|:|.:  .:::.|.::|.:|     |.|....|....|.:..||
 Frog   420 IYKMH-IFCCNLSLTEHLK-DGLSFR--VSDLTISKHQQVI-----QARNQEEKRHWVHSIKRLI 475

  Fly  1777 ---HLRSQLQRRSEKVYVLSNS---TADFRN--------------AFLKTIRQIIRESVRNMSIP 1821
               |..|..|:  .|..:|.||   :.|.|.              ||.::.||  .|..:.|..|
 Frog   476 VENHPASIPQK--AKQVLLENSFQYSPDVRLSPEPLKSPRLDELWAFSRSRRQ--SEPPQLMCSP 536

  Fly  1822 MKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRH---SAG 1883
            .:     |..:....|...||....|  :.|..|.::|.....:..| .|.|.:||:..   |:|
 Frog   537 ER-----SKKLFSALSLDSGSQHRRG--RRLSEPAKEIQAAFENSDL-VPIKHAGSEGELFPSSG 593

  Fly  1884 NI---------------------DYDN--------LSGSQEADD----------LPPSVGVVHYA 1909
            ::                     :.||        ||||....:          |...:|::   
 Frog   594 SLRSSDSVCTLESSILEVADEVYEEDNSFSLPEEALSGSLSITEEILELLKKRGLQADLGIM--- 655

  Fly  1910 SGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQ-----------QQQQQQQLMQQGHA 1963
                  :|.:.....|             |:.||.:|.|.           :.:...|||:  ||
 Frog   656 ------EQSESLALAG-------------SNTEPEEQLQNYEPIEIKTTGTEAENDLQLMK--HA 699

  Fly  1964 HAHPHPH-----PHPRE-PPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRT 2022
            :..|.|.     ..|.: |....:||.|::..||             ||:.|:|.:|      .:
 Frog   700 NVFPGPEVLCDSMDPLQYPSKASVRQGHINSESS-------------EEEEQKGDLR------ES 745

  Fly  2023 PNHL--TLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVA 2085
            |.|:  .|....|..:.:|                          .:|::.|:..:         
 Frog   746 PLHMLEELEREETSDLCNT--------------------------ENPEQKEILDK--------- 775

  Fly  2086 ASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAE 2150
                        |..::..:.:.....||:                              .|..:
 Frog   776 ------------LCLNELENTELSGCIQSE------------------------------NSSVD 798

  Fly  2151 RLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVA 2215
            ....||::|.:...|  :..|...|.:||                   |.|.|::          
 Frog   799 DTGGSQELAKLELLP--EKNEKSLKTKRD-------------------STLTQDD---------- 832

  Fly  2216 YMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTT 2280
              ..|.|:..:..|.||....:...:.|:|..|..:|::                          
 Frog   833 --RLLIERIKNYYDTAEAGVSYLSKEDSISYIPTGVVKD-------------------------- 869

  Fly  2281 GPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRRQIYISP---DRCK 2342
                             |:.....::.::|.   |.|......||:..|..:|:..|.   .|..
 Frog   870 -----------------SILRFNYILQQEVK---KDKEKSLFGSTEYIGRNKQVSTSRKPWSRLD 914

  Fly  2343 SQGSSPVRIIKIKSPRT-SLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGP 2406
            .....|:.:.:||||.| .|..:.:.||....|...::     :..|:|                
 Frog   915 KDSQVPLPLAEIKSPITLPLEQESEYLSCAEIRKAWKE-----KEKPNP---------------- 958

  Fly  2407 DPGILKPPSSPAKSKSPDRSCLKKGGPS-------HVCSVETLSPRVSPRGSMDHLSPDRGMTSS 2464
                ::..::|.:.|    .|.|:.|.|       ..|..:.      |:.|.:.|  .:|.||.
 Frog   959 ----IESIATPRRGK----LCKKRMGASEDALVIMEECDADV------PQASKEIL--PKGDTSK 1007

  Fly  2465 SCLRHSPRSSFDSHGESDHNLDVPH-----GSRKRSMSAHG--SFETGTRPRAQETYQYYPVYDN 2522
            ...:.|..... :..|:.|.:.:|.     |..|......|  .:||..|...:.:.:.  :...
 Frog  1008 EQKKQSMEEKI-TRQENHHKIIIPSMIGDPGESKEICCPSGLSLYETEDRCLLENSEKI--INKV 1069

  Fly  2523 QTCSDHY---VAAAPTGRYGGG----TSSRSR-----LSKSLERSTSRDSTTTSSSYGHRAYG-- 2573
            |..:..|   :....|.|..|.    |..:|:     |.:.:|...:..|.|...||||....  
 Frog  1070 QLLAKMYSEKIGRMKTQRRNGDNKRPTVYQSKAIVETLPQVIEEKAADKSVTEPHSYGHLVIHET 1134

  Fly  2574 -------------VSPDR-----------NYVVFSS-GPLRSQSAENTFSSQPIYDPLPRHPPQP 2613
                         :|..|           |.|.:|| .||   |::.|.|.||:.|.|    ..|
 Frog  1135 LLHINCIQENSPLLSAAREITGELYKEYLNTVDYSSTQPL---SSKETLSEQPLEDKL----QIP 1192

  Fly  2614 LHQPPMHH---QQQQQQQQQQQYMSYAPE 2639
            |.:.|:..   :...:..::|:...:|.|
 Frog  1193 LTEEPVIEIMTKLSLESNEEQEVTIHADE 1221

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 62/211 (29%)
PH2_Tiam1_2 1650..1823 CDD:269957 51/206 (25%)
PH 1693..1812 CDD:278594 35/138 (25%)
plekhg2XP_002938639.3 RhoGEF 179..352 CDD:395496 59/195 (30%)
PH_PLEKHG1_G2_G3 334..478 CDD:270063 43/163 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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