DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and prex2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_031759716.1	Gene:	prex2 / 100490424	XenbaseID:	XB-GENE-6048678	Length:	1603	Species:	Xenopus tropicalis

Alignment Length:	477	Identity:	114/477 - (23%)
Similarity:	205/477 - (42%)	Gaps:	80/477 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1459 VVMELVDTERTYVKHLNNLLEHYLEPM------KRETFLSNAEINALFGNIHEIVTFQRQFLQNL 1517
            |:.||:.|||.||..|..|:..:...|      |.:..::...:..||.||.:|:...::||..:
Frog    24 VLSELLKTERDYVGTLEFLVSAFFHRMMQYAALKADKNVTEETVKILFSNIEDILAVHKEFLSLI 88

  Fly  1518 EESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQE 1582
            |:.|..||            |.|..:|:.||.:...|.:|..:|::|.||||:|........::.
Frog    89 EDCLYPEP------------NALQEVGNCFLRFKERFAIYDEYCSNHEKAQKLLLEINKIRTVRT 141

  Fly  1583 FL---AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAE 1644
            ||   .....::.....||.||:.|||||.||||||:::...|..:..::|.:.:||:.|:.|..
Frog   142 FLLNCMLLGGRKNTDVPLEGYLVAPIQRICKYPLLLRELLKRTPKKHSDYVCVVDALQAMKAVCT 206

  Fly  1645 HINEMQRIHEEYGAIFDHLFRQHQKSCK-QPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHA 1708
            :|||.:|..|:...:.:  ::.|.:..: ..|..:..::|.:|         .|.||..|.....
Frog   207 NINEAKRQMEKLEVLEE--WQSHIEGWEGSSITDTCTEMLMHG---------VLLKISSGNIQDR 260

  Fly  1709 MCFVFKSAVVFLCKERLRQKKKLMGVSSKNATN-EVEIIRYQVLIPVTEVQVRASSAKDMDSHFL 1772
            :.|:|.:.:|: ||.:.|:.|     ::|.:|: ...|.|.::...|.||:.......|..|...
Frog   261 VFFLFDNLLVY-CKRKQRRLK-----NNKASTDGHRYIFRGRINTEVMEVENVDDGTADFHSSGN 319

  Fly  1773 -----WELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSV 1832
                 |: ||     .....|.:|....|.:.:..:|:.   |::|..|..|:   ..|....:.
Frog   320 TVVNGWK-IH-----NTAKNKWFVCMAKTPEDKQEWLEA---ILKERERRKSL---RLGMEQDTW 372

  Fly  1833 SGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGN------IDYDNLS 1891
            ...|.||              ....::...||:....:.||.:...:...|:      ::...:.
Frog   373 MMISEQG--------------EKLYKMMCKHGNLIKDRKKKLTSFPKCFIGSEFVDWLLEIGEIH 423

  Fly  1892 GSQEADDLPPSV---GVVHYAS 1910
            ..:|..:|..::   |::|:.|
Frog   424 KQEEGVNLGQALLENGIIHHVS 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	60/196 (31%)
		PH2_Tiam1_2	1650..1823	CDD:269957	37/179 (21%)
		PH	1693..1812	CDD:278594	28/124 (23%)
prex2	XP_031759716.1	RhoGEF	24..209	CDD:395496	60/196 (31%)
		PH_Collybistin_ASEF	215..362	CDD:269931	35/172 (20%)
		DEP	379..459	CDD:413322	11/81 (14%)
		DEP_2_P-Rex	471..563	CDD:239887
		PDZ	672..740	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910