DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and arhgef11

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_017952119.2 Gene:arhgef11 / 100489979 XenbaseID:XB-GENE-992398 Length:1607 Species:Xenopus tropicalis


Alignment Length:1951 Identity:365/1951 - (18%)
Similarity:632/1951 - (32%) Gaps:623/1951 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   501 IEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQ-----QQQGPPQRSSRHQHH 560
            :|..|...:::.|.....:..||.:..||   ...:::|.|...|     :..|..||....| .
 Frog     9 VEIQPIHTDILIDTSDVTSRLSSLSSASD---GAAERRSPGHQRQPCESNESTGLVQRCVIVQ-R 69

  Fly   561 HQQAPNVTPT-----------PGSPTSRLLLEYE---MHLRNTLAKGMDAESYSLHTFEALLSQS 611
            .|.....|.:           ||....|..::..   :.:..||.    |.|..:...:.:.|.:
 Frog    70 DQNGFGFTVSGDRIVLVQSVRPGGAAMRAGVQEGDRIVKVNGTLV----ANSSHIEVVKLIKSGA 130

  Fly   612 MENLEFAESLPGSNQRSPYPLRRPNAKS----STLPLPPHRP-----LSTIRDKERDRDRDGYYS 667
            ...|....|.|.|...|.||.....:.|    |.||:||..|     :..|...:..:|.| :..
 Frog   131 YVALTLLGSPPPSMGISGYPQDLSTSVSPRNISVLPMPPPPPPPLPQMHHITGPKPLQDPD-FQK 194

  Fly   668 DRNELIRE--RERERDRGYLSD-HNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGH 729
            ...|::..  ::.|.|...|.| :|.|.::|..........|....:|.                
 Frog   195 HATEILWNMLKQEEADLQNLCDVYNKSPNSSLQEQIERARKRVHQLQHK---------------- 243

  Fly   730 GMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYK---------SARADS-LEQRAEFIRQDSLR 784
              :.|:|||:|      |.|.|....|||   |||         |...|| |:...|.|   |..
 Frog   244 --IRQEIPGTG------DLLRSYSDCSSL---GYKVKEGRLSVDSQDGDSGLDSGTERI---SSL 294

  Fly   785 SEYLSDRESRYGIVQQASIEST-----------------------DSRMCYL-TSSEISDDDRMS 825
            |||..:|.|   ::....::|:                       .|...:: ||.::||..:.:
 Frog   295 SEYSMNRNS---VLSDLGMDSSHTSPIIPTKLFHHHYHHHHHRRQGSDTAFIATSEQVSDPMKST 356

  Fly   826 LTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWK 890
            :.....|.|.|.      |..:.....              |..:::...|..|.....|     
 Frog   357 IICPEEDYDHGY------YMTEQLDGL--------------FQDLERLKTRPAHMGVFLR----- 396

  Fly   891 GYWVCLKG--TTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYL 953
              ::..:.  ..||||.|       .||. :||        .|....|.|..::   ..|.|.  
 Frog   397 --YIFSQADPNPLLFYLC-------AEAC-QHL--------SPTDAFPLRKEVW---NIFLDK-- 438

  Fly   954 FQAPCQVEL-ENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSV 1017
             .||.:::: |..:|.|.|                .|...|..| :|..|:...:  :.|:|:. 
 Frog   439 -SAPLRIKIPEQLLNEIES----------------RLRNSEDIR-DKFSEAQGAM--LPEIQEQ- 482

  Fly  1018 VTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLT----HVSRPTKNTL 1078
            :.|..|:..:....|..|.:|..|..:..|.| .:|:.|..:|   :.:|:    .:|.|....|
 Frog   483 IQDYRTKRTMGLGSLYGENDLLDLEIDPHRER-QVAAKQIAQL---EDILSKYEKEISSPMAFAL 543

  Fly  1079 NKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFK 1143
            |....:                     ||......||       :.:|.:|..:..|::....| 
 Frog   544 NMYVKY---------------------AGIHTQDIRP-------ASTSEKSQSIPDREKWLPFF- 579

  Fly  1144 VAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVP---------H 1199
               |.|..|:...::..|.|:        :..||:..:  :.|.:......:.||         :
 Frog   580 ---PKNKKSSNAKKEDKSAED--------KKRNPILKY--INKPKSTSQSTFHVPLSPGEVKPGN 631

  Fly  1200 RNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKS 1264
            ..::|:::.:|.::           ::....|:::...|...:|:::...:.|:  .:.|.|.  
 Frog   632 VRNIIQHFENNQQY-----------DVPEHNLQRLSTGSFPEDLLDSDGTRLEV--KLGRSES-- 681

  Fly  1265 VAMHNGIIKGDEIMVINGAI------VSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRV 1323
                   :||.|.:..:..:      .||:||.......:..||.|....|....          
 Frog   682 -------LKGREELKKSRKVDNVPRSRSDVDMDAAAEATRLHQSASSSASSLSAR---------- 729

  Fly  1324 TDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQL 1388
                  ||..|.||..|.:....      :.:|....|.:.|.|...|..               
 Frog   730 ------SLDNPTPPYTPKLCRRS------IESPNLGFTGELLLSNLQEDD--------------- 767

  Fly  1389 AVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDA 1453
                     :|.|....|.....:::                         .|.....:..|...
 Frog   768 ---------LGHLSDLDPEPDAQNWQ-------------------------HTVGRDVALHLLPK 798

  Fly  1454 EKLR-KVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNL 1517
            |:.| :|:.||..||.::::.|..|...:.:.|::|..|:..|:..:|.|:.|::.......:::
 Frog   799 ERARQEVIHELFVTEASHLRVLRVLDLIFYQRMRKENLLTPDELWLVFPNLPELIEIHNSLAESM 863

  Fly  1518 EESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVN-----HFKLYSS-FCASHSKAQKVLHPNEG 1576
            :...:..|             |:..||...|...:     ..::.:: ||:....|.:::...:.
 Frog   864 KRLREEGP-------------VIKEIGDLMLLRFDGAAGEEVRMEAAKFCSYQISALELIKAKKR 915

  Fly  1577 NHA-----LQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEAL 1636
            ...     :||  |..|| |.....|:..::..:||:.||||||:.:...|::...||..|....
 Frog   916 KETRFSLFMQE--AESNP-QCRRLQLKDLIVSEMQRLTKYPLLLENVLKHTESGTQEHEKLYRCR 977

  Fly  1637 KGMEKVAEHINEMQRIHE------EYGAIFD--HLFRQHQKSCKQ--PIDLSPGDLLYYGGVEWL 1691
            .....:.:.:||..:..|      ||....|  ||.|.:.....:  .:||:...:::.|.:.| 
 Frog   978 DRCRDILKFVNESVKQAENEHRLAEYQKRLDASHLERSNNPLAAEFKNLDLTTRRMIHEGPLTW- 1041

  Fly  1692 NISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTE 1756
            .:.|      |.::||.:  :.:..:|.|.|:   .:|.::...||..|:..:  .:..:|.:..
 Frog  1042 RVRD------KTIDLHVL--LLEDLLVLLQKQ---DEKLVLKCHSKTTTDTKQ--TFSPVIKLNS 1093

  Fly  1757 VQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIP 1821
            |.|| |.|.|..:.|    |...|.|   ..::|.|...|:..:|.::..:.:....::||.   
 Frog  1094 VLVR-SVATDKKALF----IICTSDL---GPQIYELVALTSSEKNTWMDLLEEATNGAMRNP--- 1147

  Fly  1822 MKNFGGSSGSVSGHSSQGMGSMGYPG----NSQTLERPKQQITIVHGSHTLGKPK-KKSGSQRHS 1881
                                    ||    .||.:.||.....::..:|   .|| ...|..|| 
 Frog  1148 ------------------------PGATKRKSQDINRPTSASMVLQRAH---MPKLTAEGVLRH- 1184

  Fly  1882 AGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQ 1946
                   |....|..|:                          |..:.:|...::....||....
 Frog  1185 -------NSEDPQSGDE--------------------------GAGEFLGQKPDVVLEEPEREDD 1216

  Fly  1947 QQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIR----QPHLHHHSSDIERIDPGTKSEG--- 2004
            :..:.:....|           |.|...|......|    ..|:.:|..::        :||   
 Frog  1217 EDDEARTPTLL-----------PIPSKEEDAGGGTRGLDSSNHIPYHWPEV--------TEGLAE 1262

  Fly  2005 -----------------------EEDSQQGTI-RPKATLGRTPNHLTLSTTSTLSVGSTGSQARL 2045
                                   |.||....: .|:..|..||:          .:|..|     
 Frog  1263 SALDDVHNLRRLILKNMLHHGHSEYDSSSAPVAEPEDDLTPTPS----------VIGGHG----- 1312

  Fly  2046 IQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAAS-FNLSLGS-SGSLFASDA----- 2103
                ||..:....::::|   ..|::..|.|:.|..::.:.| .|...|. .||....:.     
 Frog  1313 ----HPWDTMTDAVLENL---DADQTTEEKETSVSRSESSRSVLNFPHGERPGSRDGEETAWSLV 1370

  Fly  2104 -RDNQTQSRTQSQIHSLHPS------------------------PRQSPRQSPRQ---------- 2133
             |..|:.|..|:|...||..                        |..|..||..|          
 Frog  1371 ERYPQSSSVQQNQSEQLHSEDHNNRSYRVVRKAEVVGNYDVISLPDSSQSQSVLQEAGGGAIVDG 1435

  Fly  2134 ----------SPKQDIEVIEIFESEAERLAASQQVAVVHQHPSD-QARESGHK---QRRDRDRNP 2184
                      |.|:|.||.|.. :.::||::          ||. ::|||.|.   |.......|
 Frog  1436 NFFYVTASATSTKEDPEVSESL-TNSDRLSS----------PSFLESRESNHTPTYQSEFSTPPP 1489

  Fly  2185 TETDATARFMDKHLSDLEQENLTDGTCDIV--------AYMESLREKAFDPQDLAEDTG-----D 2236
            ..|::     |..||||....|.....||:        |.:..|:|.....|:|....|     |
 Frog  1490 RSTES-----DPLLSDLLPPKLVIQDVDIIFRTIEHLTAKLHRLKEVESAHQELLRSLGRSATED 1549

  Fly  2237 H 2237
            |
 Frog  1550 H 1550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 24/127 (19%)
PH 873..974 CDD:278594 23/103 (22%)
TIAM1_RBD 1141..1219 CDD:176413 13/86 (15%)
PDZ_signaling 1221..1308 CDD:238492 16/92 (17%)
RhoGEF 1456..1647 CDD:238091 42/202 (21%)
PH2_Tiam1_2 1650..1823 CDD:269957 39/182 (21%)
PH 1693..1812 CDD:278594 26/118 (22%)
arhgef11XP_017952119.2 PDZ_signaling 63..137 CDD:238492 13/78 (17%)
RGS 357..501 CDD:413378 38/212 (18%)
RhoGEF 805..989 CDD:214619 41/199 (21%)
PH_PRG 1006..1143 CDD:275426 34/158 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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