Protein Alignment sif and fgd1

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_004914246.1
• Gene: fgd1 / 100489369
• XenbaseID: XB-GENE-6453246
• Length: 913
• Species: Xenopus tropicalis
• Alignment Length: 561
• Identity: 122/561 - (21%)
• Similarity: 207/561 - (36%)
• Gaps: 163/561 - (29%)

  Fly  1334 PPPPTDP----PVMSE-------------EMITGL---------IVPAPGWN-GTSKDLYSPEAE 1371
            ||||:.|    |.::.             ..:|.|         |:|..... |...|: :|:.:
 Frog   138 PPPPSRPLPADPRLARICLSRPDNKDGTPSAVTSLIEKFEREPIILPIERTTLGHGTDI-NPDMD 201

  Fly  1372 SSPATS-----------------FVDPAAMAAQLAVG---GVGGVVVGGLG-------------- 1402
            |||:.|                 .::|......|...   ||.|...|.:|
 Frog   202 SSPSPSLQHSGYSMGELGHKLLDLLEPEVSQGSLERRRRLGVEGGDAGEMGEQDSGGKLANRDSG 266

  Fly  1403 ---VAKP-TSRTSSF----------EIENLLKTAEQETRKSSPTGS--VTSSVSTTALTPSR--- 1448
               ::.| ||....|          |.|.....|::.:.:.|...|  ...|.....|.|.|
 Frog   267 IDSISSPSTSEEMCFLGEVDEGGREESETCYSVAQRCSARDSEGDSDMEDGSGDEGELPPERLDP 331

  Fly  1449 -QLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINA---------LFGNI 1503
             :.|..:|:.|:..||:.||:.||..|     |.|:.:.....:..|...|         :|.||
 Frog   332 CEFTARQKVYKIANELLQTEKAYVSRL-----HLLDQVFCARLMDEARTRASFPVEVVMGIFSNI 391

  Fly  1504 HEIVTFQRQF-LQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKA 1567
            ..|..|.:|| |..||:.:. |.|.|.            .||..........|:|..:..:..:|
 Frog   392 CSIYCFHQQFLLPELEKRMQ-EWDSNP------------RIGDILQKLAPFLKMYGEYVKNFDRA 443

  Fly  1568 QKVLHPNEGNHALQEFLAARNPKQQHSS----TLESYLIKPIQRILKYPLLLQQ-MRNLTDTRAD 1627
            .::|  |.......:|.:.....|:..:    ||:.::::|:|||.:|.|||:. :..|.:...|
 Frog   444 MELL--NVWTERSSQFKSVIQEVQREEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPEDSKD 506

  Fly  1628 EHVHLCEALKGMEKV---AEH----INEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSP-GDLLY 1684
            .    |:|.|.:|.:   |||    |.:|:|:|:        |.:.::....:...:|| .:|:.
 Frog   507 R----CDAEKSLELIATAAEHSNAAIRKMERMHK--------LLKVYELLGGEEDIVSPTNELIK 559

  Fly  1685 YGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQ 1749
            .|.:  |.:|     .|.|........:|...::: |..:||    |:|.            :|.
 Frog   560 EGHI--LKLS-----AKNGTTQDRYLILFNDRLLY-CVPKLR----LIGQ------------KYS 600

  Fly  1750 V--LIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEK 1788
            |  .|.|..::::.||:.::...|.........:||.|:|:
 Frog   601 VRARIDVEGMELKHSSSPNLTRTFRVSGKQRSLELQARTEE 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	53/212 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	28/142 (20%)
		PH	1693..1812	CDD:278594	20/98 (20%)
fgd1	XP_004914246.1	PHA03247	<6..207	CDD:223021	16/69 (23%)
		RhoGEF	341..525	CDD:238091	53/207 (26%)
		PH1_FGD1	557..664	CDD:275392	23/109 (21%)
		FYVE_FGD1_2_4	691..755	CDD:277280
		PH2_FGD1-4	780..885	CDD:270056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910