DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and sptbn4

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_002938861.2 Gene:sptbn4 / 100488521 XenbaseID:XB-GENE-1013360 Length:2545 Species:Xenopus tropicalis


Alignment Length:2793 Identity:482/2793 - (17%)
Similarity:860/2793 - (30%) Gaps:963/2793 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 INNNTRRKTKSTEDMNVDTS---TLKRMLKPMPSTESPVTSPEMGRRRYNYY-NANAAQTLGHPP 435
            ||::..:......|:..|..   .:.::|:.:...:.|  .|..||.|.:|. |.:.|.......
 Frog    64 INSHLSKVPLRVNDLYTDLRDGYIITKLLEVLSGEQLP--KPTRGRMRIHYLENVDKALQFLKEQ 126

  Fly   436 HMHQHGMAMGMGGGGGGGHHIMNNN---TMG--------------RASSQSSRFSGSRSSHEI-- 481
            .:|...:         |.|.|::.|   |:|              |..::.||  .:||:.:.  
 Frog   127 RVHLENV---------GSHDIVDGNHRLTLGLIWTIILRFQIQVIRIETEDSR--ETRSAKDALL 180

  Fly   482 ------GRGYPPRNLYLELERERSCIEGSPPS--DNVMFDNQCYATTPSSSNGN--SDQDQSYGQ 536
                  ..|||..|           |:....|  |.:.|....:...|...:.|  :..:.:|..
 Frog   181 LWCQMKTSGYPEVN-----------IQNFTTSWRDGLAFSALIHRHRPDVIDFNKLTKSNATYNL 234

  Fly   537 QQSSGQHPQQQQG------PPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEM----------- 584
            |.:... .:||.|      |...:..|                |..:.::.|.:           
 Frog   235 QHAFNT-AEQQLGLTKLLDPEDVNMEH----------------PDEKSIITYVVSFYHYFSKMKA 282

  Fly   585 ------HLRNTLAKGMDAESYSLHTFEALLSQSME----------NLEFAESLPGSNQRSPYPLR 633
                  .:...|.|.::.|. .:..:|.|.|:.:|          |.:||.||.|..|:      
 Frog   283 LAVEGKRIGKVLDKAIETEK-DIVKYEVLASELLEWIERTIAIITNQKFANSLLGVQQQ------ 340

  Fly   634 RPNAKSSTLPLPPHRP------------LSTIRDKERDRDRDGY-------YSD----------- 668
               .:..|......:|            |.:|:.|.|:.....|       .||           
 Frog   341 ---LQVFTTYCTTEKPCKFQEKGNLEVLLFSIQSKMREEKCKLYVPSEGKNISDINKAWACLEKA 402

  Fly   669 --------RNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGS 725
                    ||||||:.:.|    .||......:..|                 :.|.|.:..:.|
 Frog   403 EHEREVALRNELIRQEKLE----LLSQRFDQKAAMR-----------------EAWLSENQRLVS 446

  Fly   726 GSGHGMMTQQIPGSGHKRSPWDS-----------LPSLRQDSSLNDSGYK-----SARADSLEQR 774
            ....|.....:..:..|....::           :..|.|:  |...||.     ||:.|::   
 Frog   447 QDNFGYDLPAVEAAMKKHEAIEADISSYEERIQVVADLAQE--LEAEGYYDICRISAQKDNI--- 506

  Fly   775 AEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGE-- 837
               :||.:|..:.||.|.:|  :.|..|::.....|.|:    |...|.|.:  .:|.:|.|:  
 Frog   507 ---LRQWNLLKDMLSSRRAR--LEQNLSLQKIFQEMVYM----IDWMDEMQV--PLSSKDFGKHL 560

  Fly   838 ---------------SVMASPYKAKATGTAASSFN-------CTGAVRKAGFLSVKKWLLRKKHQ 880
                           .:.|...:..:...||..|.       |...|              ..::
 Frog   561 LEVEDLLQKHCLLEADIAAQTERVNSLNQAALKFTQMTDYQPCDPQV--------------ICNR 611

  Fly   881 IELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLS 945
            :|..|.        ||:|...|   .:.|.|..                    |..:|.:.|...
 Frog   612 VEHVRS--------CLEGLRQL---AEKRRGEL--------------------EESRRLWCFLQE 645

  Fly   946 TAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHM 1010
            ..             |.|.|:.......:|..:..:..:..|.||.:     .|.:..:.:.:| 
 Frog   646 VE-------------EAEGWIREKEQILSAPQSYGKDLSSVLRLLSK-----HKILVGELRGRH- 691

  Fly  1011 AELQQSVVTDQET-----------RHQIQTQILQWEENLERLHCEQFRLRCYMASL--------- 1055
            |.|||::...::.           |.:::...|:| |||::. |:..:.:...||.         
 Frog   692 AMLQQTLQKGEQVLAKRRKGMSGLRQRMEQVRLKW-ENLQKA-CDNHQQKLQEASSFYQFSADTM 754

  Fly  1056 -QSGELPNPKSLLT-----HVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRR 1114
             .:|.|.:...|::     |....|::.:.|....||.                      ..|.:
 Frog   755 ELAGWLQDTYRLVSSDDFGHDEYSTQSLVKKHRAETVE----------------------IEKHK 797

  Fly  1115 PPMLSRSNSGSSRRSMQMNS--RDEPEKTFKVAMPDNAYSTV---------YLRDAMSVEEFLAS 1168
            ..:|     |..::..::.:  ||:.:....:...:..|..|         :|:||:.|.:... 
 Frog   798 VAVL-----GLRQQLSELGAEYRDQVDVQITIVEVEQLYGEVVEVSALRSQWLQDALDVYKMFG- 856

  Fly  1169 ACARRNLNPMEHFVRVKKR--RDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILY--------- 1222
                 .:|..|.::..|::  ..||     :|.|.:.:|...|..|.::..|..|.         
 Frog   857 -----EVNSCEVWIDEKEQWLMKME-----IPQRLEEVEVVQHRFESLDQEMNSLMGRVLDVNQI 911

  Fly  1223 -------------QVELQRTTLEQMWGFSVEAELIENAERQDEL------------CCYV-SRVE 1261
                         :|...:..|...|...|  ||:|  :|:::|            |..| |::.
 Frog   912 VQQLLEGGHPSSSEVRACQDHLNSRWNRIV--ELVE--QRKEQLSSVLRLQNYFLECNEVKSQIR 972

  Fly  1262 DKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDD 1326
            :|...|........|                |..||..::.||.|..:.....|.||.:.:..:.
 Frog   973 EKRRTMETPQCGSGE----------------LGGVLSLQRKLSSMEAALLALEPKLVQLQQDAEI 1021

  Fly  1327 MIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVG 1391
            :         .|..|..:.|::......:..|:...:.|...|          |...:|.:|   
 Frog  1022 L---------ATSHPSQAMEVLVHFEEISGEWDALKRTLQGCE----------DSLTVANKL--- 1064

  Fly  1392 GVGGVVVGGLGVAKPTSRTSSF--EIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAE 1454
                               ..|  :::|.|            |..|.:..:..|......|.:||
 Frog  1065 -------------------QQFIQDLDNFL------------TWLVKTQTAVAAEELPSNLAEAE 1098

  Fly  1455 KL------RKVVMELVDTERTYVKHLNNLL---EHYLEPMKRETFLSNAEIN-----ALFGNIHE 1505
            :|      .|..:...:.|...::.:|:||   |..|..:..:.:|...|:.     .::.|..|
 Frog  1099 RLLGLHGSLKEEISRYEEEYNKIQAVNDLLSLEEADLPYLSLQQWLQKLEVGWNKLLQMWENRRE 1163

  Fly  1506 IVT-------FQRQFLQ-----NLEES-------------------------LDLEPDFNKFEHC 1533
            ::.       |.|.|.|     |.:||                         ..:|.:..|....
 Frog  1164 VLVQAHIFHLFLRDFKQAEACLNTQESTLAHVELPNTVEGVEAAIKKHKDFVTTMELNVQKVSVA 1228

  Fly  1534 GQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSK-----AQKVLHPNEGNHALQEFLAARNPKQQ- 1592
            .:....|..:|:.|   .:|.:...|.....|:     |||.|.....:..||.||...|.... 
 Frog  1229 VEAGESLIRLGNVF---ADHVQERISAIQKRSQRNTALAQKWLQRLRDHLQLQHFLQNCNELDAW 1290

  Fly  1593 -HSSTL------ESYLIKPIQRILKYPLLLQQM--------------RNLTDTRAD--------- 1627
             |..||      .....||.::.||:...:.::              :.|...:.:         
 Frog  1291 VHEKTLMARDSSRDLSQKPHKKWLKHQAFMAELSQNKGWLEKIEKEGQQLIQEKPELAGVVKKKL 1355

  Fly  1628 EHVHLC--EALKGMEKVAEHI---NEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPG------- 1680
            |.:..|  |.....:..|:.:   .:..::.:.|..:...|:  |.|...||:|..|.       
 Frog  1356 EEIRQCWVELESSTQAKAQQLFQATKADQVVQNYSELGKRLY--HLKEQLQPVDPVPDVSSVNTQ 1418

  Fly  1681 ----DLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATN 1741
                :.:.....||         .|:..||.|.  :....:....::.|.:|:..:|      |.
 Frog  1419 LKRLETMESQMEEW---------YKEVGELQAQ--IASLPLEVASQKALEEKQNEVG------TT 1466

  Fly  1742 EVEII-----RYQVLIPVTEV-QVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFR 1800
            .|.:|     |.::|:...|| ||    .:|::....|        :|.|      |..:|:...
 Frog  1467 IVRLIEPLKERRRILLASKEVHQV----TRDLEDEIFW--------VQER------LPLATSKEH 1513

  Fly  1801 NAFLKTIRQIIRESV---RNMSI------PMKNFGGSSGSVSGHSSQGMGSMGYPGNSQ------ 1850
            .:.|:.::|:|:::.   |.:.:      .:....|:..|:....::|: .:||....:      
 Frog  1514 GSNLQIVQQLIKKNQNLRREIQVHSPRVDDILERAGAIASIRTPEAEGV-RLGYESLGEMWNMLR 1577

  Fly  1851 -TLERPKQQITIVH----------------GSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADD 1898
             ..||.:|.:.|.:                ....|.....:.|....|...:...:|...|..::
 Frog  1578 DETERRQQLLDITYQVQQYYFDVGEVETWLSEQELLMMNDEKGKDEQSTLQLLKKHLMLEQTIEN 1642

  Fly  1899 LPPSVGVVHYAS------GHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQL 1957
            ...::..:....      ||...:|:        ||....:..:..|..:...:::.:.:||..|
 Frog  1643 YEETIAQLSRQCRTLLDLGHPDSEQI--------SKRQSQIDRLYVSLKDLVDERKGRLEQQYWL 1699

  Fly  1958 MQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRT 2022
            .|.                             |.:::.::       :..:::..:.....||:.
 Frog  1700 FQL-----------------------------SREVDELE-------QWIAEKEVVAGSPELGQD 1728

  Fly  2023 PNHLTL-------STTSTLSVGSTGSQA------RLIQSSHPPASYQPVLMKDLGKPSPDESELE 2074
            ..|:||       ..|.|.|||.....|      .||...|..|:........:.:...|..|| 
 Frog  1729 YEHVTLLQEKFTEFATETGSVGQERISAVNQMVDELIDFGHSDAAIIAEWKDGVNEAWADLLEL- 1792

  Fly  2075 SESEVHAAQVAASFNLSLGSSGSLFASDARD--NQTQSRTQ--SQIHSLHPSPRQSPRQSPRQSP 2135
              .|..:..:|||..|      ..|.:|.::  :|.:.:.|  .::.:..........|....|.
 Frog  1793 --METRSQMLAASHEL------YKFFNDCKEVLSQVEEKKQRLPEVKAQEAKLSAGSLQRILSSF 1849

  Fly  2136 KQDIEVI-----EIFESEAER---LAASQQVAVVHQHPSDQARESGHKQR----RDRDRNPTETD 2188
            :.||:|:     ::.|:.|:.   .|.....|:|   .|:|......|:.    .|.....|.|.
 Frog  1850 EHDIQVLVTQVRQLQENAAQLRTVYAGENAAAIV---TSEQEVMRAWKELLTSCEDCRLQITSTT 1911

  Fly  2189 ATARFMDKHLSDLEQENLTDGTCDIVAYMESL------REKAFDPQDLAEDTGDHQQNDSSLSPE 2247
            ...:|:          ||..   |::::|||:      .||..|...:......||...|.:...
 Frog  1912 DRIKFL----------NLVR---DLISWMESITCQIGAEEKPRDVSSVEVLMSYHQGLKSEIESR 1963

  Fly  2248 PQTIVENTQ--QTVVVDIESPS------------------------------------------- 2267
            .:.|.:..:  :|:|:: :.||                                           
 Frog  1964 NKRIADCVELGKTLVLN-KRPSSDEIKQSLDRLMAKKKEMLEKWNKHWEWLQQMLEVHQFAQEAG 2027

  Fly  2268 ---------RPATESDSTGNTTGPSERSGDETEE---------------EATTSSLASHIVVIDK 2308
                     .|..:|...||       |.||.|:               |...||| ..:..::|
 Frog  2028 VADAWLTAQEPIVKSPELGN-------SVDEVEQLIRRHEAFRKTAAVWEERFSSL-RRLTTLEK 2084

  Fly  2309 KVDKIFKAKSPERPASTKVKGGRRQIYISPDRCK-SQGSSPV-RIIKIKSPRTSLSDQGKRLSVC 2371
                 .||:..::||:..:  ||:   :.||... |...||: |....::..|.| ||.:.||: 
 Frog  2085 -----LKAEQSKQPATPLL--GRK---VFPDTTDYSARPSPLSRQTVYENSETKL-DQKEALSI- 2137

  Fly  2372 SSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGPDPGILKPPSSPAKSKSPDRSCLKKGGPSHV 2436
              .|..|..:...|......|.    |.::....|:.  |:|.....::|..|:       |...
 Frog  2138 --PDGGQQEIRRARAEKGETRV----GYVRQDIKPER--LQPKMDHVETKVADK-------PLAA 2187

  Fly  2437 CSVETL-SPRVSPRGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHGSRKRSMSAHG 2500
            ..||.. ...:.....|.:|:.::.....|  ||:.|.. |.|              :|.:....
 Frog  2188 QEVERAEKTEIKFAQGMANLTVEKPEIKGS--RHTERKR-DRH--------------ERRLERQE 2235

  Fly  2501 SFETGTRPRAQETYQYYPVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSKSLERSTSRDSTTTSS 2565
            |.|       |||.:..|               |..|       |.|..|.|||..|.:..|...
 Frog  2236 SSE-------QETPKQEP---------------PERR-------RDRHEKRLERQGSSEQETPKQ 2271

  Fly  2566 SYGHRAYGVSPDRNYVVFSSGPLRSQSAENTFSSQPIYDPLPRHPPQPLHQPPMHHQQQQQQQQQ 2630
            ....|.                 |.:....|.....|....||..|:............:|.|::
 Frog  2272 EQSERR-----------------RDRHERRTERQDTIEQDKPRTEPEKQAGKATLADIVEQLQEK 2319

  Fly  2631 QQYMSYAPEMGGYTGCQHDPQGGYQLSSSAPEYTTCIDCLYQKRPSXHKSRVRQSRTRKKTPR 2693
            :.:.:   ..||.......|.|..:|    ||.||        ||. .::|.|....|:..|:
 Frog  2320 EAFQN---SSGGQDSPARVPNGVDKL----PERTT--------RPDRPRARDRPKPRRRPRPK 2367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 16/124 (13%)
PH 873..974 CDD:278594 14/100 (14%)
TIAM1_RBD 1141..1219 CDD:176413 16/88 (18%)
PDZ_signaling 1221..1308 CDD:238492 22/121 (18%)
RhoGEF 1456..1647 CDD:238091 48/282 (17%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/198 (18%)
PH 1693..1812 CDD:278594 24/124 (19%)
sptbn4XP_002938861.2 SAC6 48..>454 CDD:227401 81/461 (18%)
SPEC 425..637 CDD:238103 46/289 (16%)
SPEC 642..849 CDD:238103 40/254 (16%)
SPEC 746..955 CDD:238103 40/250 (16%)
SPEC 956..1169 CDD:238103 45/281 (16%)
SPEC 1171..1379 CDD:238103 36/210 (17%)
SPEC 1276..1484 CDD:238103 39/226 (17%)
SPEC 1488..1588 CDD:197544 20/118 (17%)
SPEC 1592..1804 CDD:238103 37/258 (14%)
SPEC 1804..1906 CDD:351773 19/110 (17%)
SPEC 1915..>2079 CDD:238103 30/185 (16%)
PTZ00121 <1985..2345 CDD:173412 84/464 (18%)
PH_beta_spectrin 2401..2505 CDD:269975
DUF5069 <2473..2540 CDD:374811
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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