DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Tiam2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006227964.1 Gene:Tiam2 / 100362710 RGDID:2324148 Length:1714 Species:Rattus norvegicus


Alignment Length:1761 Identity:538/1761 - (30%)
Similarity:815/1761 - (46%) Gaps:347/1761 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   440 HGMAMGMGGGGGGGHHI-----------------MNNNT----------MGRASSQSSRFSGSRS 477
            ||.|.|.||.|.....:                 :|..|          ..||::..:.|.|:..
  Rat    44 HGWAHGSGGAGYKSRSLARSCLSHFKSHQPYATRLNGPTCKVSKGTAYSKHRANAPGNDFQGNNG 108

  Fly   478 S-------HEIGRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCY------ATTPSSSNGNSD 529
            :       |.:||           |...|.|.....:.:::   .||      |:||...:..|.
  Rat   109 AFLPENGFHYVGR-----------ESGESHITSRDCNGHLL---TCYGRHDSIASTPPGEDRRSP 159

  Fly   530 Q---------DQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPNVT----PTP--------GS 573
            :         |.....:..:|.:|  .:||.:..|......:.:|.:.    |.|        ||
  Rat   160 RVLIKTLGKLDGCLRVEFHNGGNP--HKGPSEDPSEPVQLLRYSPTLAAETCPVPESRRLSGAGS 222

  Fly   574 PTSRLLLEYEMHLRNTLAKGMDAES--YSL---HTFEA------LLSQSMENLEFAESLPGSNQR 627
            ..|:.....:..||::....:.:||  |..   :..||      .|:.|..:.....|.|.|:.:
  Rat   223 SASQRPSPTDSCLRSSKGSSLSSESSWYDSPWGNAGEASEVDGTFLAPSALDPSLPSSFPPSDTK 287

  Fly   628 SPYPLRRPNAKSSTLPLPPHRPLSTIRDKERD-----RDRDGYYSDRNELIRERERERDR-GYLS 686
            .|:     |..||         ||::|:..:|     |...|.....||.|..:....:| .:.|
  Rat   288 KPF-----NQSSS---------LSSLRELYKDANLGCRSPSGTCLSSNEYISSQVGLNNRVSFAS 338

  Fly   687 DHN-------------SSFS-NSRCASCIGESA------RAQWFRHSDGWRSGSSTIGSGSGHGM 731
            |.:             |||: ..|.:..:.|.|      :|:..|.|| | :||.          
  Rat   339 DMDVPSRVDHRDTMQYSSFTLPCRKSKALTEDAAKKDTLKARMRRFSD-W-TGSL---------- 391

  Fly   732 MTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSL------RSEYLSD 790
                   |..||       .|::..|...|.|..:.:|.|....:...|.|.      .::.|..
  Rat   392 -------SRKKR-------KLQEPRSTEGSEYFDSHSDGLNADVQGPTQTSALLWSGGSAQTLPH 442

  Fly   791 R-ESRYGI----VQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATG 850
            | ||.:.|    :||...|:      ::...|      ||.|...:.|...|:|.:|.....:..
  Rat   443 RSESTHAIGSDPLQQNIYEN------FMRELE------MSRTNMENAETSTETVESSSESLSSLE 495

  Fly   851 TAASSFNC-TGAVRKAGFLSVKKWL-LRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRS 913
            .....|.. .|.|||||:|..|..: |:|:.::||..:|.||.|||.|||.||:||....:....
  Rat   496 QLDLLFEKEQGVVRKAGWLFFKPLVTLQKERKLELVARRKWKQYWVTLKGCTLMFYETYGKNSTD 560

  Fly   914 VEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFA 978
            ..:||:..:..:.:|:|.:|||||::::||||.::||.|||||..|.:||||:.:||||||:.||
  Rat   561 QNSAPRCALFAEDSIVQSVPEHPKKEHVFCLSNSYGDVYLFQATSQTDLENWITAIHSACASLFA 625

  Fly   979 RHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHC 1043
            :..||..|:.||:.:...|.:.|:.|.|:|.|||||.|||:|.:.|..|:.||.|||:|||:.|.
  Rat   626 KKHGKEDTVRLLKSQTRGLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIRQWEQNLEKFHM 690

  Fly  1044 EQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLN------ 1102
            :.||:|||:||||.||||||||||...|||:|..|.:|||.:||||||.:|:|..|.|.      
  Rat   691 DLFRMRCYLASLQGGELPNPKSLLAATSRPSKLALGRLGVLSVSSFHALVCSRDDSALRKRTLSF 755

  Fly  1103 -----------------NLLAGRGATKR------------------RPPMLSRSNS--------G 1124
                             :.||.:|..||                  :.|..|.::|        |
  Rat   756 TQRAKSKKGLFSSLKGLDTLARKGREKRASITQMFDSSHSHGYLGTQLPQNSTNSSEVHDLHLYG 820

  Fly  1125 SSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRD 1189
            ||..|...:|..|.: |: |...||...||.::....||:.||.||..|:|.|..:.::::|..|
  Rat   821 SSADSTLRDSTWEVQ-TY-VHFQDNEGVTVIIKPEHRVEDVLALACKMRHLEPTRYGLQLRKVVD 883

  Fly  1190 MEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELC 1254
             |...:.||...:.::..:::.  :||....:|.|:|.:|.....:||:|.|::   .|.|....
  Rat   884 -ESVEWCVPALYEYMQEQVYDE--IEVFPLSVYDVQLTKTGDMTDFGFAVTAQV---DEHQHLSR 942

  Fly  1255 CYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVG 1319
            .::|.|...|:|...|:.||:||..:||..|||||:..:|::..|:.                ||
  Rat   943 IFISDVLPDSLAYGGGLRKGNEIRSLNGEAVSDLDLKQMEALFSEKS----------------VG 991

  Fly  1320 IMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAES---SP-----AT 1376
            :         :||..|..|...:.:              :.:..||:|.:.:|   ||     ..
  Rat   992 L---------TLVARPADTRASLCT--------------SCSDSDLFSRDQKSLLPSPNQCQLLE 1033

  Fly  1377 SFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSF--------EIENLLKTAEQETRKSSPTG 1433
            .|:|.....:......|..|..|     ...|.|...        ::|...::|||.......|.
  Rat  1034 EFLDNFKKTSTNDFSNVPDVTTG-----LKRSHTEGTLDQVPHREKMEQTFRSAEQIVELCRGTT 1093

  Fly  1434 SVTSSVSTTALTP---SRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAE 1495
            |:.:...:....|   :|.|:||::||||:.||||||::|||.|:.|.|.||||::.||||:..|
  Rat  1094 SMEAPTDSRDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDE 1158

  Fly  1496 INALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSF 1560
            :.:|||::.|::.||:.||:.||:.:....||:..|...|||.:||::|.:||||.:||||||.|
  Rat  1159 MESLFGSLPEMLEFQKVFLETLEDGISASSDFSVLETPSQFRKLLFSLGGSFLYYADHFKLYSGF 1223

  Fly  1561 CASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTR 1625
            ||:|.|.||||...:.:.|.:.||.||||.:|||||||||||||:||:|||||||:::.:|||..
  Rat  1224 CANHIKVQKVLERAKTDRAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDHE 1288

  Fly  1626 ADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEW 1690
            ::||.||.||||.|||||.||||||:|:|:||.:||.|..:...:.|:..:||.|:||.:..|.|
  Rat  1289 SEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSW 1353

  Fly  1691 LNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEI--IRYQVLIP 1753
            ||....|||.:|.:||  ..||||.||:.:.||..:.||||.. :|:.|.|..::  .:::.|||
  Rat  1354 LNPFLSLGKARKDIEL--TVFVFKRAVILVYKENCKLKKKLPS-NSRPAHNSADLDPFKFRWLIP 1415

  Fly  1754 VTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVR-- 1816
            ::.:|||..:....:::..|||||.:|:::.|.|.::.|..|.::.:.:.:|.||.|:||:.|  
  Rat  1416 ISALQVRLGNTAGTENNSTWELIHTKSEIEGRPETIFQLCCSDSESKTSIVKVIRSILRENFRRH 1480

  Fly  1817 ------------NMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLG 1869
                        :..:|:||....|..::  ||:.:..:....:|:....|.:..::.....:| 
  Rat  1481 IKCELPMEKTCKDRLVPLKNRVPVSAKLA--SSRSLKVLRTSSSSEWPSDPSKGNSLDSDECSL- 1542

  Fly  1870 KPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVT 1934
                .||:|.           ||...|:........|.....|....:. |.|....|..:.|..
  Rat  1543 ----SSGTQS-----------SGCPVAESRQDCKSTVLEKDAHEVLAEF-PDGLIKESDILSDEE 1591

  Fly  1935 EITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPP---PIRQPHL-HHHSSDIER 1995
            |      :.|...:|....:...:|.........|..|.....||   |..||.| ..|...|:|
  Rat  1592 E------DFHHPLKQGSPTKDIELQFQRLRISEEPDMHSTGQQPPLTGPGEQPKLVRGHFCPIKR 1650

  Fly  1996 IDPGTK 2001
            ....||
  Rat  1651 KANSTK 1656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 60/125 (48%)
PH 873..974 CDD:278594 46/101 (46%)
TIAM1_RBD 1141..1219 CDD:176413 22/77 (29%)
PDZ_signaling 1221..1308 CDD:238492 28/86 (33%)
RhoGEF 1456..1647 CDD:238091 109/190 (57%)
PH2_Tiam1_2 1650..1823 CDD:269957 63/188 (34%)
PH 1693..1812 CDD:278594 41/120 (34%)
Tiam2XP_006227964.1 PH1_Tiam1_2 506..632 CDD:269937 60/125 (48%)
Tiam_CC_Ex 646..743 CDD:408184 58/96 (60%)
RBD 835..905 CDD:128731 20/74 (27%)
PDZ_signaling 912..997 CDD:238492 32/112 (29%)
RhoGEF 1122..1311 CDD:214619 107/188 (57%)
PH2_Tiam1_2 1313..1485 CDD:269957 62/174 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 226 1.000 Domainoid score I2435
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 608 1.000 Inparanoid score I891
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002962
OrthoInspector 1 1.000 - - otm45318
orthoMCL 1 0.900 - - OOG6_105244
Panther 1 1.100 - - O PTHR46001
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2782
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.950

Return to query results.
Submit another query.