Protein Alignment sif and Plekhg6

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_002729474.2
• Gene: Plekhg6 / 100362241
• RGDID: 2318544
• Length: 783
• Species: Rattus norvegicus
• Alignment Length: 1011
• Identity: 190/1011 - (18%)
• Similarity: 321/1011 - (31%)
• Gaps: 364/1011 - (36%)

  Fly  1336 PPTDPPVM----------------SEEMITGLIVPAPGWNGTSKDL-------YSPEAESSPATS 1377
            ||.:.|:.                |.:...|:..|.   .|.:.||       |.|.|:.|..|.
  Rat     6 PPNEGPLQGLVASRIETYGGRHQTSAQSSAGITYPR---GGPALDLSRRRLQHYVPFAKGSGQTR 67

  Fly  1378 FVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQ--------ETRKSSPTGS 1434
            .:.|.....:...|...|  ||.....|....:.:.|:|..|.|...        |.|:....|.
  Rat    68 GLSPQEPDPEKRHGNYFG--VGSPYFPKFKEVSKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGE 130

  Fly  1435 VTSSVSTTALT----------PSRQLTDAEKLRKVVMELVDTERTYVKHL---NNLLEHYLEPMK 1486
            ...|..|...:          .:|:|...:   :.:.||:.||..|::.|   .:||...|..::
  Rat   131 GGDSALTIEKSWKELVLGHKEMNRELCHQQ---EALWELLTTELIYLRKLKIMTDLLAAGLLNLQ 192

  Fly  1487 RETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYV 1551
            |...|:......||||:.:::...|:|.:.:     |:|........||..:.: ::.:.||.:.
  Rat   193 RVGLLTEVSAETLFGNVPKLIRTHRRFWEEV-----LQPILEDTRTSGQPLDPV-SLQNGFLTFG 251

  Fly  1552 NHFKLYSSFC------ASHSKAQKVLHPNEGNHALQEFLA-ARNPKQQHSSTLESYLIKPIQRIL 1609
            ..|:.|..:|      .::::.|:     :.|...:.|:. ....|:....||...||||.|||.
  Rat   252 QRFQPYIQYCLRVKQTMAYAREQQ-----DTNPLFRTFVQWCEKHKRSGRQTLGDLLIKPHQRIT 311

  Fly  1610 KYPLLLQQ-MRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQ 1673
            |||||||. ::...:.||  .:.|...:..:|...:|||
  Rat   312 KYPLLLQAVLKRSPEPRA--QLALDNMIVAVESFLQHIN-------------------------- 348

  Fly  1674 PIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKN 1738
                                    |.:::|                      .:::.||.|:.:
  Rat   349 ------------------------GLVRRG----------------------EEQESLMAVAQR- 366

  Fly  1739 ATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAF 1803
                  |..|:||.|         |:::::.       |||             ..||.|    .
  Rat   367 ------IGPYEVLEP---------SSEEVEK-------HLR-------------QFSTLD----L 392

  Fly  1804 LKTIRQIIRESVRNMSI--PMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSH 1866
            :..|..:..|:.|.:.:  |::...|..|                         |..:.:...|.
  Rat   393 MTPIEGVAPENTRQLLLEGPVRMKEGREG-------------------------KMDVYLFLFSD 432

  Fly  1867 TL--GKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKT 1929
            .|  .||::|....:.....:..:.|......|  |.|..::|..                ..:.
  Rat   433 VLLVTKPQRKVDKAKVIRPPLMLEKLVCRPLRD--PHSFLLIHLT----------------EFQC 479

  Fly  1930 VGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAH----------------PHPHPHPREPPP 1978
            |.....:.|||.....|..|:.||.|..:|:..|..:                ..|.|.|..|.|
  Rat   480 VSSALTVHCSSSTERTQWLQKTQQAQATLQKLKAEEYVQQKRGLLALYRDQGRESPSPRPSTPSP 544

  Fly  1979 PPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQA 2043
            .                 |..:.:||.  :.:.|:.|:..:....:..|.|.|...|....|:
  Rat   545 E-----------------DSQSSAEGR--ALEFTVIPRLVVTEDTDEDTPSVTDDTSDSGYGT-- 588

  Fly  2044 RLIQSSHPPASYQPV-------LMKD--------------LGKPSPDESELESESEVHAAQVAAS 2087
             ||.|| |..|..|:       |.:|              |....||...|:..|       |..
  Rat   589 -LIPSS-PKDSQSPLNRLRSKALRRDPRLTFSTLELRDVPLRPQPPDPQALQRRS-------APE 644

  Fly  2088 FNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERL 2152
            ....:...|||                        ||::|   |..|.::| |.:.......|.|
  Rat   645 MPEGILRGGSL------------------------PRRAP---PTWSEEED-ETLTPGNVVVETL 681

  Fly  2153 AASQQVAVVHQHP--SDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVA 2215
            :.:|:.:.:...|  :|.|.||           |.|:           :|.::..|:.|
  Rat   682 SRAQRRSPLPHSPAHTDSAGES-----------PWES-----------TDEDEGPLSPG------ 718

  Fly  2216 YMESLREKAFDPQDLAEDTGDH---QQNDSSLSPEP 2248
                ||.::...:|:..:..:.   |:.:.:|.|||
  Rat   719 ----LRPRSLRAEDMLREIREELASQRIEGALEPEP 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	51/201 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	21/174 (12%)
		PH	1693..1812	CDD:278594	18/118 (15%)
Plekhg6	XP_002729474.2	RhoGEF	162..348	CDD:395496	51/198 (26%)
		PH_PLEKHG5_G6	405..503	CDD:270064	21/140 (15%)
		fibronec_FbpA	<566..761	CDD:411474	51/256 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910