DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and arhgef38

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_009289887.1	Gene:	arhgef38 / 100317614	ZFINID:	ZDB-GENE-090313-83	Length:	762	Species:	Danio rerio

Alignment Length:	896	Identity:	171/896 - (19%)
Similarity:	290/896 - (32%)	Gaps:	353/896 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1399 GGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPS----RQLTDAEKLRKV 1459
            |.:.:|....|:.|.:.|...|..|    |.||.|  .|.:::.|:.|.    |::.   |..||
Zfish    52 GDISIATLVRRSQSDKTEYSSKLKE----KMSPHG--LSLLASPAMDPEEIRHRKMI---KRSKV 107

  Fly  1460 VMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESL-DL 1523
            :.|||.||..|.:.|...:...|.|::....:   :::.||.||..:.......|..|:::: |.
Zfish   108 IEELVRTEGDYQRDLELCINEVLLPLREAQVV---DVDRLFTNIESVCDVSNDLLLRLQDAIADP 169

  Fly  1524 EPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF-KLYSSFCASHSKAQKVLHPNEGNHALQEFLAAR 1587
            :|:..             .||..|:...... ::|..:|         .|.:|.|.:|:.:.|..
Zfish   170 DPETQ-------------LIGEVFIQTKAVIEEVYKIYC---------YHHDEANASLKSYEAQE 212

  Fly  1588 NPKQQHSSTLE------------------SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCE 1634
            :.:||....:.                  |.||||:|||:||||||.::.|.|.|...:|..|.|
Zfish   213 DIQQQFRRCISALKKIYDLEGKPNLLDMGSLLIKPVQRIMKYPLLLAELWNATPTDHPDHRPLQE 277

  Fly  1635 ALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNI------ 1693
            ||..::.:..:|||.:|                :|........|..:....|.:...||
Zfish   278 ALTTVKIINININEFKR----------------RKDIVLKYKRSDDETSLMGKLNKFNIHSIRKK 326

  Fly  1694 SDFLG---KIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVT 1755
            ||.|.   ||..|:|....            .|...:::||.....|.....|:.|...:|....
Zfish   327 SDRLTSYFKILTGVEPQVR------------DEAFDKEEKLFRNLEKAVRQLVKNISCYLLYTQE 379

  Fly  1756 EVQVRASSAKDMDS------------------------HFLWELIHL---------------RSQ 1781
            .:.|...:|:|::|                        ||...:.||               :..
Zfish   380 MISVAVQNAQDLESIMKDPDKIDTNGFHQKKNGNDPYKHFKDHMEHLVVAPLSSLLGMFASPQKL 444

  Fly  1782 LQRRSEKV--YVLSNSTADFRNA---------------------------------------FLK 1805
            :|:|.:|:  |.   |..|.|::                                       .:|
Zfish   445 IQKRYDKLLDYC---SQLDSRSSNEEQGLAKRDYEALNAQLLEELQCFNQAARTILTNCLICIVK 506

  Fly  1806 TIRQII---RESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMG-YPGNSQTLERPKQQITIVHGSH 1866
            .||:::   :..|:.:.:|:.||.....|:    .:.:.::| :..|||.|...|
Zfish   507 LIRKLMDAAQPPVQQLPVPLSNFNEVQNSI----MEELSNLGFFKENSQKLMERK---------- 557

  Fly  1867 TLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVG 1931
                                                                  ..|..|.|.:
Zfish   558 ------------------------------------------------------VSFEKREKKM- 567

  Fly  1932 DVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHH-------- 1988
                    :||   ..:|.::|:.:|:::                  .|::|  |:.
Zfish   568 --------APE---ILRQTEEQRARLLEE------------------YPVKQ--LYQLKRNCNAC 601

  Fly  1989 HSSDIERIDPGTKSEGE-----EDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQS 2048
            ...||..:      |||     ||..     |..:..|...|             |||....:.|
Zfish   602 QEKDISLL------EGELVALLEDRD-----PMGSSSRWLVH-------------TGSVQGYVYS 642

  Fly  2049 SHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQ 2113
            |...| |.|  .:::.: .||:.:                ||      |||.|.:|.:..:|.:.
Zfish   643 SFLKA-YNP--QREVTE-RPDDFD----------------NL------SLFVSASRSSSMRSFST 681

  Fly  2114 SQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQH 2164
            |.    ..||:.:|:.....|..|....:..|::..|:....|:    :||
Zfish   682 SD----SVSPQSAPQDELDTSDDQHFYAVYAFKARCEQELTLQE----YQH 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	53/210 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	40/264 (15%)
		PH	1693..1812	CDD:278594	33/210 (16%)
arhgef38	XP_009289887.1	RhoGEF	107..291	CDD:279015	53/208 (25%)
		BAR_DNMBP	343..524	CDD:153273	26/195 (13%)
		SH3	591..646	CDD:302595	16/78 (21%)
		SH3_DNMBP_C2	703..758	CDD:213017	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3224
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840