DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and kalrna

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_017213230.1 Gene:kalrna / 100148988 ZFINID:ZDB-GENE-100921-4 Length:2968 Species:Danio rerio


Alignment Length:1939 Identity:366/1939 - (18%)
Similarity:625/1939 - (32%) Gaps:716/1939 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   572 GSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAESLPGSNQRSPYPLRRPN 636
            |.|:....||..:|...||             :|.:.....|..:..::|....||   ||...|
Zfish   442 GLPSEMQDLESAIHHHQTL-------------YEQVTQAYTEVSQDGKALLDVLQR---PLSPGN 490

  Fly   637 AKSSTLPLPPHRPLSTIRD-----KERDRDRDGYYSDRNELIRER--------ERERDRGYLSDH 688
            |:|.|......:.:..|.|     ....|..:..:..|...:.:|        :.::...::.:|
Zfish   491 AESLTATANYSKAVHCILDVVHEVLHHQRRLENIWQHRKVRLHQRLQLCVFQQDVQQVIDWIENH 555

  Fly   689 NSSFSNSRCASCIGES---ARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLP 750
            ..:|.:....  :|:|   |||...||.|......:|..:........:|:..:| :..|     
Zfish   556 GEAFLSKHTG--VGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTG-ECDP----- 612

  Fly   751 SLRQDSSLNDSGYKSARADSLEQR-AEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLT 814
                     :..||:||  .||.| .:|:|:...|...|                  |..:.:.|
Zfish   613 ---------EEIYKAAR--HLEVRIQDFVRRVEQRKLLL------------------DMSVSFHT 648

  Fly   815 SSE-----ISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAG-------- 866
            .::     :.|..:..|....||..|....:...::.:.|.|..::.|    |.|.|        
Zfish   649 HTKELWTWMEDLQKELLEEVCSDSVDSVQELIKQFQQQQTATLEATLN----VIKEGEDLMQQLR 709

  Fly   867 --FLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIM 929
              .:|..|    ..|...:|...|             :....:..:|...|...:..|.:|    
Zfish   710 DSAMSSNK----MPHTSSIAHIEG-------------VLQQLEEAQGHMEELFHERKIKLD---- 753

  Fly   930 QPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSI-----------HSACAAAFARHRGK 983
                       || |.....:.|..:.  ..||:.|...:           .|.......||..:
Zfish   754 -----------IF-LQLRIFEQYTIEV--TAELDAWNEDLVRQMNEYTGEEPSLAEQRLQRHAER 804

  Fly   984 TGTLHLLQEEIFR----------------------------------LEKAIESDHKLKHMAE-- 1012
            ...:..:..|:.:                                  ||...|..|:|...||  
Zfish   805 KLAMTNMTYEVMQQGQDLHQYIMEVQASGIELTGEKEVDLATQVQELLEFLHEKQHELDMSAEHT 869

  Fly  1013 ---LQQSVVTDQETRH-QIQT-QILQW--------------------EENLERLHCEQFRL---- 1048
               |:|.|    :.|| |.:. |:|.|                    .|.|:|.| |||:|    
Zfish   870 QKRLEQCV----QLRHLQAEVKQVLGWIRNGESMLDASMVNASSLSEAEQLQREH-EQFQLAIES 929

  Fly  1049 --------RCYMAS----------LQSGELPNPKSLLTHVSRPTKNTLNKLGVF----------- 1084
                    :.:.::          ||:|.. :|:::        ::...|:.|.           
Zfish   930 LFHANSLQKTHQSALQVQQKAEIMLQAGHF-DPEAI--------RSCAEKVAVHWQQLMLKMEDR 985

  Fly  1085 --TVSSFHAF------ICARSPSL------------LNNLLAGRGATKRRPPMLSR--------- 1120
              .|::..||      :|:...||            .::.|.....|....|::|:         
Zfish   986 LKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGAHDKLGSSSETDHVLPLISKHLEQKEAFL 1050

  Fly  1121 ----------------------SNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVE 1163
                                  |:.|||     .|:|. ||:..|..:                .
Zfish  1051 KACTLARRNAEVFLKYIHRNNVSSQGSS-----SNTRG-PEQQVKAIL----------------N 1093

  Fly  1164 EFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRN-----DLIEN----YLHNHEFVEVCMK 1219
            |.|      :..|.:.||..:||||..:...|.|..||     :.||.    ||..|    .|: 
Zfish  1094 ELL------QRENRVLHFWTMKKRRLDQCQQYVVFERNAKQALEWIEEAGEVYLATH----TCI- 1147

  Fly  1220 ILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAI 1284
                    ..::|:..|...|.|         |.|....:.::| |.|   :|:..:..|..|.:
Zfish  1148 --------GDSMEKTQGLLKEYE---------EFCISAKQTKEK-VKM---LIQLADNFVEKGHM 1191

  Fly  1285 -VSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMI 1348
             |:||... |.:|.:..:..||.|...|.:..:::||                      .||:  
Zfish  1192 HVTDLKKC-LTAVDKRYRDFSMRMGKYRCDLENVLGI----------------------SSED-- 1231

  Fly  1349 TGLIVPAPGWNGTSKDL---YSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRT 1410
                         :|||   ..|.:.:.|.....||                             
Zfish  1232 -------------NKDLELDIIPASLTGPEVKLRDP----------------------------- 1254

  Fly  1411 SSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLN 1475
             :.|:       .:|.|||                       |.|...::.||:.||:.||:.|:
Zfish  1255 -NHEV-------NEEKRKS-----------------------ARKKEFIIAELLQTEKAYVRDLH 1288

  Fly  1476 NLLEHYLEPMKR-----ETFLSNAEINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCG 1534
            ..||.||..|..     ...::|.| :.:||||.||..|... ||:.|.....|..|        
Zfish  1289 ECLETYLWEMTNGVEEIPPGIANKE-HIIFGNIQEIYDFHNNIFLKELINYEQLPED-------- 1344

  Fly  1535 QFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLES 1599
                    :|..|:.:.:.|.:|.::|.:...:.:::..:.|:     |......:...::::.|
Zfish  1345 --------VGHCFVTWADKFNIYVTYCKNKPDSSQLILDHAGS-----FFDEIQKRHSLTNSISS 1396

  Fly  1600 YLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLF 1664
            |||||:|||.||.|||:::.:..:....|   :.:.|:.|..|.:..|:...:....|  ||   
Zfish  1397 YLIKPVQRITKYQLLLKELLSCCEEGKGE---IKDGLEVMLSVPKRANDAMHVSMLEG--FD--- 1453

  Fly  1665 RQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFL--CKERLRQ 1727
                    ..:|:. |:|:..   :...:.|....|:||.:.|  .|:|:.::||.  .|:...:
Zfish  1454 --------ANLDVQ-GELILQ---DTFQVWDPKSLIRKGRDRH--LFLFEISLVFSKEIKDSAGR 1504

  Fly  1728 KKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQR--RSEKVY 1790
            .|.:.  .:|..|:|         :.||| .|.....|    ..||        :.|  .|:...
Zfish  1505 SKYIF--KNKLLTSE---------LGVTE-HVEGDPCK----FALW--------VGRTPSSDNKT 1545

  Fly  1791 VLSNSTADFRNAFLKTIRQIIRESV--------------RNMSIPMKNFGGSSGSVSGHSSQGMG 1841
            ||..|:.:.:..::|.||::|:|.:              :..:.|..|....:|..:  .|||.|
Zfish  1546 VLKASSIEVKQEWIKNIREVIQERIIHLKGALKEPIHIPKTPAKPRNNSKRDAGEDA--DSQGDG 1608

  Fly  1842 SMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVV 1906
            |                          .:|...|.:.|.|...:|.|.|||..|       :.||
Zfish  1609 S--------------------------SQPDTISIASRTSQNTVDSDKLSGGCE-------LTVV 1640

  Fly  1907 HYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHP 1971
                                      :.:.|.||   ..:...|..|..:|:::      |...|
Zfish  1641 --------------------------LQDFTASS---SSELSIQTGQTVELLER------PSDRP 1670

  Fly  1972 -----HPREPPPP-----PIRQPHLHHHSSDIERID---PGTKS-------EGEEDSQQGTIRPK 2016
                 ...|..||     |.....:.|..|.:| :|   |..|.       ||:.:| ..|::|:
Zfish  1671 GWCLVRTTEKTPPQEGLVPSSALCISHSRSSVE-MDCFFPAGKENYTVSGPEGKTES-VATLQPQ 1733

  Fly  2017 ATLG----------RTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMK-------DLG 2064
            .:|.          |:.|.|....||.:...|.||..:.|.|...        .|       |:|
Zfish  1734 PSLNSLQSSSPGPKRSGNTLKKWLTSPVRRLSHGSNIKKIPSKQK--------QKRDGRKSIDMG 1790

  Fly  2065 KPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQ 2129
            .|...:..||...:....      .||..|||       ..:..:...:.:.|:..|.|.:..:.
Zfish  1791 PPELQDDTLEERVQKEEG------TLSKSSSG-------MHSGGEEEPEDESHTPLPPPMEIIKD 1842

  Fly  2130 SPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQ-------------------HPSDQARESGHK 2175
            ...|..|..: ::...:|.|:..:|::.|:.:.:                   :|::|:...   
Zfish  1843 PSAQEEKSSV-LLASRQSSADVPSAAELVSAIEKLVKTKMTLEPGSYPGFSSVNPAEQSPIP--- 1903

  Fly  2176 QRRDRDRNPTETDATAR------FMDKHLSDLEQENLTDGTCDIVAYMESLREK 2223
                 .||| |.:..|:      |:.|.|...|::.:.|....:..:|:.:.||
Zfish  1904 -----PRNP-ELEQKAKALRGRMFVVKELIQTEKDYVKDLGIVVEGFMKRIEEK 1951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 22/145 (15%)
PH 873..974 CDD:278594 15/111 (14%)
TIAM1_RBD 1141..1219 CDD:176413 20/86 (23%)
PDZ_signaling 1221..1308 CDD:238492 19/87 (22%)
RhoGEF 1456..1647 CDD:238091 51/196 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/190 (20%)
PH 1693..1812 CDD:278594 29/122 (24%)
kalrnaXP_017213230.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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