back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and dnmbp

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_001921555.3	Gene:	dnmbp / 100005174	ZFINID:	ZDB-GENE-101026-2	Length:	1673	Species:	Danio rerio

Alignment Length:	1974	Identity:	347/1974 - (17%)
Similarity:	609/1974 - (30%)	Gaps:	750/1974 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 FAES--LPG---------------SNQRSPYPLRRPN---AKSS--TLPLPPHR--------PLS 651
            |.||  :||               |.:....||:|.:   |:||  ::.:..|.        |:|
Zfish    55 FVESVTIPGTKAGENLYVCINDFNSAEAGNLPLKRGDVVAAESSMDSVWMRGHNAWGSRGLFPVS 119

  Fly   652 TIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSD-- 714
            .|::.|        .|.|:..:.||........|..|           .:|: |||....|:.
Zfish   120 CIKELE--------LSGRSRQLSERSAAVQASELPPH-----------ALGQ-ARALMNLHAQLD 164

  Fly   715 ---GWRSGS--STIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLN-----DSGYKSARAD 769
               .:|.|.  :.||           :|..|..:...|:...|..:..:.     .|..:.....
Zfish   165 EELDFREGDVITIIG-----------LPEPGWFQGELDNRTGLFPEGFVELLGPLRSPLEEPEPQ 218

  Fly   770 SLEQRAEFIRQD-SLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDE 833
            :|||..::..:| ..|:|...|.|.....:||.                 .:|:         :|
Zfish   219 TLEQYPDYSNEDEERRAEEEKDEEPPEMEIQQC-----------------QEDE---------EE 257

  Fly   834 DDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKG 898
            ::|.....:.|:.:|.......|:....:|                 |..:...||      |:|
Zfish   258 EEGAIYGIALYEFRALEPGELDFDVGDRIR-----------------ILASMDDGW------LEG 299

  Fly   899 TTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELE 963
                  ...||.|    ..|...:.::|. :|.:|                           :.|
Zfish   300 ------QIHSRRG----VFPHRFVKIEGQ-LQTVP---------------------------QTE 326

  Fly   964 NWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLE-KAIESDHKL----KHMAELQQSVVTDQET 1023
            ..:|.|                ::...:||.:..: .:.|.||.:    :.::..|...|.|.:.
Zfish   327 TLINEI----------------SVPKREEECYTPDYTSAEEDHTVPEYGQELSIQQDHTVWDLDY 375

  Fly  1024 RHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSS 1088
            ..:.:.:  |.|.|...:|.:|......|...||...|..:
Zfish   376 FERREEE--QKENNGHNVHSDQSSQERRMTQNQSQVQPQER------------------------ 414

  Fly  1089 FHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSS--RRSMQMNSRDEPE--------KTFK 1143
                                 ...|.||..::.|.|||  .||:|:|.|..|.        :...
Zfish   415 ---------------------RRDRPPPPQTQPNRGSSSAHRSVQINRRSSPNMGRPQLPPRPSL 458

  Fly  1144 VAMPDNAYST---VYLRD----AMSVEEFL--------ASACARRN--------LNPMEHFVRVK 1185
            .|:.:..|||   ..||.    .:::.:.|        .|...|.|        .||:......:
Zfish   459 HALSNRKYSTGSHASLRQPPPAPITMNQSLNPPNKTSPNSTWTRNNGKYASYNSRNPLSSKSSGE 523

  Fly  1186 KRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMW-------GF------ 1237
            |.|..:...:...:..|:|..                     .::.:|.|       ||
Zfish   524 KNRQKKLTRHASVNDADIISG---------------------GSSEQQAWPQVQGSNGFPTSQTM 567

  Fly  1238 --------SVEAELIEN-AERQDELCCYVSRVEDKS------------VAMHNGIIK-GDEIMVI 1280
                    .:||:|.:. .|.:..|..:.:...::|            |:.|..|:. .||..:|
Zfish   568 GTLALSAKDLEAKLSQQLIEFEKSLPSHSNEATEQSRWEEVSGRLGNKVSRHFSIMDYSDENDII 632

  Fly  1281 NGAIVSDLDMMYLESVLQEEQSLSMMM--RSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTD---- 1339
            .|:..|.::.: |.|......|.|..:  |.:...||....::|           ||.||:
Zfish   633 RGSSHSSIERL-LPSTSSPSGSASSSLERRKNLRPPPPRPRVLR-----------PPAPTNTHWS 685

  Fly  1340 ---------------------PPVMSEEMITGLIVPAPGWNGTSK-------------------- 1363
                                 ||......:|......|.:|...:
Zfish   686 QTNGRITPQPYRPARPAPRPPPPCPHTNAVTPPTTSNPFYNSPDEEEIVEEMEEPEDVLEAEKEM 750

  Fly  1364 --------------------DLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTS 1408
                                |:||..|:...|....:....:.|.|        :..|.....|.
Zfish   751 EREQEQYRLLLRLEEVEREIDMYSNTAQELQAMLDEEQDETSRQQA--------LENLEFCSYTM 807

  Fly  1409 RTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKH 1473
            .|.:.|.:.|    ::.|..:|...|:.||.::.|.:...:|...||..||:.||:.||..|:|.
Zfish   808 ETLTLEQQQL----QEMTLLASQPKSLESSPASAANSEDPELRMLEKRTKVIEELLQTEHDYIKD 868

  Fly  1474 LNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRN 1538
            |...::..::|::::. :...:.:.|||||..::...|:..:.|:::
Zfish   869 LQMCVKEIIQPLQKKQ-VQGIDFDGLFGNISSVIDLSRRLNKTLQDT------------------ 914

  Fly  1539 VLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGN-----HALQEFLAARNPKQQHSST- 1596
              .:||..||.|.:..: :|..:|.:|..|..:|...|.:     |.|:.....|...::...|
Zfish   915 --DSIGQVFLSYKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLRGIYREWGKTN 977

  Fly  1597 ---LESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR------- 1651
               |.|:||||:||:::|||||.::.|.|.....:...|.||:..::::..:|||.:|
Zfish   978 YINLGSFLIKPVQRVMRYPLLLMELLNTTPESHHDRQQLSEAVMSIKEINVNINEYKRRKDLVVK 1042

  Fly  1652 --------------------IHEEYGAIFDHL---------------------FRQHQKSCKQPI 1675
                                |.::...:..||                     ||..::..|..|
Zfish  1043 YRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFI 1107

  Fly  1676 DLSPGDLLYYGGVEWLNISDFLGKIK-----KGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVS 1735
                           .|||.:|..|:     |.|...:.|.::......:..||.::..:.  :|
Zfish  1108 ---------------RNISLYLQHIRESASVKVLAAISFCDIYTERQQQMDPERFQRAHRC--IS 1155

  Fly  1736 SKNATNEVEIIRYQVLIPVTEV------------------------QVRASSAKDMDSHFLWELI 1776
            .|..|...|.....|:.|:|::                        :.||...||.
Zfish  1156 DKQFTEFKERTEALVITPLTQLLNMFTGPHKLIQKRRDKLLDYDNCKERAERLKDK--------- 1211

  Fly  1777 HLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNF---------------- 1825
            .::.:||........|:....|....|.:....:....||......::|
Zfish  1212 RVQEELQTARNNYEALNAQLLDELPKFHRAAEDLFTSCVRGFVQAQRDFISLTLGELTPLLQLSG 1276

  Fly  1826 -GGSSGS-VSGHSSQGMGSMG-------YPGNSQTLERPKQQITIVHGSHTLGKPKKKSG----S 1877
             ||:.|: ||....:....:.       :|.|..|..|...:...:...:| .||:....    :
Zfish  1277 LGGTEGNLVSLFQEEHTRVLDLLQSFSFFPENLPTTVRKTFEKKTLEKQYT-KKPQAPPNYVLQT 1340

  Fly  1878 QRHSAG-NIDY--DNLSGSQE----ADDLPPS------VGVVHYASGHTHGQQMQPAGFRGRSKT 1929
            ..|.|| .:.|  :||..::.    |.||..|      |||:         :|..|.|.:.|...
Zfish  1341 DEHRAGLLVRYGPENLYQAERNFNAAQDLDVSVLEGDIVGVI---------KQQDPMGSQNRWLI 1396

  Fly  1930 VGDVTE--ITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSD 1992
            ...||:  :..|..:|:..::.|.
Zfish  1397 DNGVTKGFVYSSFLKPYNPRRSQS----------------------------------------- 1420

  Fly  1993 IERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLS-TTSTLSVGSTGSQARLIQSSHPPASYQ 2056
                |...:|:...:|..|...|..:...:.:.||.: .|||:|..:..:|
Zfish  1421 ----DVSIESQSSNESGYGGSSPMFSRQNSNSTLTFNQETSTVSFTTATTQ-------------- 1467

  Fly  2057 PVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHP 2121
                        ::|.....:|....::..:            :|:.||            ||.|
Zfish  1468 ------------NQSNTRPNNESTPRKIRET------------SSNQRD------------SLEP 1496

  Fly  2122 SPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTE 2186
            ..|.||...            |:.|:   .:..|::    :..||.:: .:.|:...|.|:| |.
Zfish  1497 GFRNSPNHK------------EVSET---AIRNSRE----YSEPSHRS-STNHRDSVDSDQN-TP 1540

  Fly  2187 TDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDP----QDLAEDTGDHQQNDSSLS-- 2245
            |::..|.      ||.:   ||.:        |.|...::|    ||.....|.||:.:...|
Zfish  1541 TNSRDRL------DLSE---TDSS--------SSRNSRYEPSSRYQDSKASYGSHQRQNGDYSGQ 1588

  Fly  2246 -------------PEPQTIVENTQ 2256
                         |||:..::..|
Zfish  1589 QRRPQYTPEEYIEPEPEPEIDGHQ 1612

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.