DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and sptbn4a

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_001342754.3 Gene:sptbn4a / 100003123 ZFINID:ZDB-GENE-060531-133 Length:1409 Species:Danio rerio


Alignment Length:1735 Identity:321/1735 - (18%)
Similarity:549/1735 - (31%) Gaps:671/1735 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   965 WVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIES--DHKLKHMAELQQSV--VTDQETRH 1025
            |:.  |.|..|..||::.....:....||:.:.:..:.|  :.|||.:.|....:  .|..:.|.
Zfish    19 WMK--HQAFMAELARNKEWLAKIEQEGEELIQEQPELRSVVEMKLKEIRECWSHLENTTKVKARQ 81

  Fly  1026 QIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFH 1090
            ..:||                       :.::.:||.             |.|:.|      ..|
Zfish    82 LFETQ-----------------------NHRTTDLPT-------------NNLSDL------DQH 104

  Fly  1091 AFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVY 1155
            ..|....|..|       |:|....|.|.:.....|::..::.|.::..:.|.            
Zfish   105 LNIIQEQPPTL-------GSTHTTQPTLLQPRPTFSQQLQRIQSWEDQMQLFH------------ 150

  Fly  1156 LRDAMSVEEFLASACARRNLN------PMEHFVR----VKKRR--------------DMEDHNYF 1196
                 .|.|.:|.|..||...      |....||    :|:||              |:||...:
Zfish   151 -----GVSEVMAGAEHRRPEGEEQGGVPETRIVRLIEPLKERRRILLASKELHQVTQDLEDEIIW 210

  Fly  1197 VPHRNDL------------IENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAER 1249
            :..|..|            ::|.:.|||.:::      ::::::..||         |::|.|| 
Zfish   211 IQERLHLASSIEYGTNLQSVQNLMKNHEALQM------EMQVRKGRLE---------EVLERAE- 259

  Fly  1250 QDELCCYVSRVEDKSVAMHNGIIKGDEI-MVINGA-------IVSDLDM----MYLESVLQEEQS 1302
                          :||    .::..|: :|..||       .|..::|    :.|::|.|.:|.
Zfish   260 --------------AVA----ALRTPEVELVREGAGHVRQLWEVLQVEMERRTVMLDAVNQAQQY 306

  Fly  1303 LSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGW-NGTSKDLY 1366
            .|   ::::||                                           .| :|....:.
Zfish   307 YS---QAAKTE-------------------------------------------SWLSGQKLQVL 325

  Fly  1367 SPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTA---EQETRK 1428
            :.|..:..|::.   ..:..|||:                 .:|    :||..:|.   .|:.|:
Zfish   326 NEEKGNDEASTL---RLLKEQLAL-----------------EQT----VENYAETVGSLSQQCRR 366

  Fly  1429 SSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSN 1493
            ....|...|...|      :|....::|...:.:||:..:|.::.     :::|..:||      
Zfish   367 MLELGHPDSEQIT------KQQAHIDRLYVSLKDLVEQRKTKLEQ-----QYWLYQLKR------ 414

  Fly  1494 AEINAL--FGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKL 1556
             |:.||  :.:..|.|....:..|:||....|:..|.      ||.:...|:|...:..||  |:
Zfish   415 -EVEALEKWISEREAVASSTELGQDLEHVTVLQSSFT------QFSSETRAVGQKQMDSVN--KM 470

  Fly  1557 YSSFC-ASHSKAQKVLHPNEG---------------------NHALQEFLA------------AR 1587
            .:... .|||.|..:....:|                     ::.|.:|..            .|
Zfish   471 VNEMIDCSHSDAATIAEWKDGLNESWADLLELMETRAQMLAASYQLHKFFTDCQEVLVQIEGKMR 535

  Fly  1588 NPKQQHSSTLESYLIKPIQRIL-----KYPLLLQQMRNLTDT-----------RAD--------- 1627
            ...:..|..:.|.....:||:|     ...||:.|:|.|.:.           :||         
Zfish   536 QLPEVRSCQVSSANPGTLQRLLHSFEHSLQLLVSQVRQLQENAVQLRAIYAGEKADAILSREQEV 600

  Fly  1628 -----EHVHLCEA-----------LKGMEKVAEHINEMQRIHEEYG--------AIFDHLFRQHQ 1668
                 |.:..||.           ::....|.|....|..|..:.|        ::.:.:..|||
Zfish   601 MQAWKELLVACEGSRVQVTTVTDKIQFFAVVRELSMWMDGIMGQIGPNDDARDLSVLEGMMSQHQ 665

  Fly  1669 KSCKQPIDLSPGDLLYYGGVEWLNISDFLGK------------IKKGLE--------------LH 1707
             :.|..::....:.::.  ||       :||            :|:.||              ||
Zfish   666 -NLKSKMENKSKNFVHC--VE-------MGKMLLAARNPAAEEVKEKLEYVMAKQKEMNERWDLH 720

  Fly  1708 AMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVT--------EVQ--VR-- 1760
                          .|:|:|.|:.:..:....|.:..:...:.:.|:|        ||:  :|  
Zfish   721 --------------WEKLQQAKQRLQSTQTGLTEQPWLTIKEPITPITREAGGGTDEVEELIRRH 771

  Fly  1761 ------ASSAKDMDSHF--LWELIHLRSQLQR-------RSEKVYVL----------SNSTADFR 1800
                  ||:.||   ||  |.:...::.:|.:       .|.:::.|          |:|::.||
Zfish   772 EAFRKAASTWKD---HFSSLRQAEKMKEELNKPPSTSSLLSRQMFPLSCLVPSSSSSSSSSSLFR 833

  Fly  1801 N---------------------AFLKTIRQIIRESVRNMSIPMKNFGGSS--------------- 1829
            |                     ....|:.|.:..|: |...|:.|  |||               
Zfish   834 NPLQDSLLESKPGPDHMHSIEHTVTHTLPQRLGSSL-NPYTPVMN--GSSYHGLQQPSGVVNESP 895

  Fly  1830 ----------GSVSGHSSQGMG-SMG-YPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSA 1882
                      .|:...|.||:. .:| :.|||.:.....||..:.           :.||..||.
Zfish   896 LYQSIKQQGVSSLDNSSYQGLNQQVGVFGGNSSSYTGLNQQGALA-----------EDGSSYHSL 949

  Fly  1883 GNIDYDNLSGSQEADDLPPSVGVVH----YASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEP 1943
            .::.               :||||.    ||..|......||        .:..:.:......|.
Zfish   950 NHLG---------------AVGVVEPKIGYAWQHLKADCFQP--------KINHIHKAVSPLLEA 991

  Fly  1944 HQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDS 2008
            |         :.||...|           ...|.||....|.|....|.::|...|::|    |.
Zfish   992 H---------RAQLASAG-----------ANMPAPPVGMDPSLEMIHSRLQRDPRGSRS----DP 1032

  Fly  2009 QQGTIRPKA--TLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDES 2071
            |...:|.:.  .|||       .|:|...:     ||||        :..|::::........|.
Zfish  1033 QMDHLRREREYRLGR-------QTSSEQEI-----QARL--------NELPLIVRQERYRRRMER 1077

  Fly  2072 ELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQI----------HS----LHPS 2122
            :..||.|....|.....:.|...||. ..||.:.:..:..|.::|          |:    ..|:
Zfish  1078 QSSSEQEASGKQRVQKHDSSDAESGK-EPSDKKPSGEKRSTMAEIVEQVQEREACHARGEVYRPA 1141

  Fly  2123 ------------PRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHK 2175
                        ||...|..||:.|:..    |..|....|.|.:|.|....|.|:......|..
Zfish  1142 SSLSAPVSRLDRPRARDRPKPRRRPRPK----EPEEPRRSRSAPAQSVPSTPQPPTHTVHHEGFL 1202

  Fly  2176 QRR----DRDRNPTE------------------TDA---TARFMDKHLSDLE--QENLTDGTCDI 2213
            .|:    .::|:|..                  .||   |..:.|:.|.:|.  :.:.|:|    
Zfish  1203 YRKHEEEGKERSPNSKSWVNLFCVLKQGEIGFYKDARHTTTPYNDEPLLNLAICEFDTTNG---- 1263

  Fly  2214 VAYMESLREKAFDPQDLAEDTGDH---QQNDSSLSPEPQTIVENTQQTVVVDI---ESPSRPATE 2272
              |.:  ::..|..:..||  ||:   .:::..|.....:|  |.....:.||   |..:..:|:
Zfish  1264 --YKK--KKNVFILRTTAE--GDYIFLAKDEEDLKGWVNSI--NASLKEIEDIAKYEKATNSSTD 1320

  Fly  2273 SDST-----GNTTGPS---ERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKG 2329
            .|.:     .....||   |||  |..|::..|..:..|...||        .|..|.||.|.:|
Zfish  1321 PDKSERKERSEGAEPSEGVERS--ERSEKSERSDRSDKIEASDK--------SSERRDASEKERG 1375

  Fly  2330 GRRQIYISPDRCKSQGSSPVRIIKIKSPRTSLSDQGKRLSVCSSR 2374
            .|             |....|..:....|....|:|.|.|..|.:
Zfish  1376 DR-------------GERGERAERGDRERGERGDRGSRGSSTSGK 1407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 6/19 (32%)
PH 873..974 CDD:278594 3/8 (38%)
TIAM1_RBD 1141..1219 CDD:176413 22/113 (19%)
PDZ_signaling 1221..1308 CDD:238492 19/98 (19%)
RhoGEF 1456..1647 CDD:238091 49/267 (18%)
PH2_Tiam1_2 1650..1823 CDD:269957 45/264 (17%)
PH 1693..1812 CDD:278594 34/202 (17%)
sptbn4aXP_001342754.3 Spectrin <1..84 CDD:278843 15/66 (23%)
COG5281 <134..>509 CDD:227606 90/521 (17%)
SPEC 196..407 CDD:238103 51/325 (16%)
SPEC 302..514 CDD:238103 51/307 (17%)
SPEC 515..727 CDD:238103 38/235 (16%)
PH 1196..1303 CDD:278594 21/118 (18%)
PH-like 1198..1301 CDD:302622 21/114 (18%)
PRP38_assoc 1322..1403 CDD:289628 25/103 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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