Protein Alignment Ret and Tie1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_445997.1
• Gene: Tie1 / 89806
• RGDID: 621642
• Length: 1137
• Species: Rattus norvegicus
• Alignment Length: 788
• Identity: 209/788 - (26%)
• Similarity: 324/788 - (41%)
• Gaps: 217/788 - (27%)

  Fly   391 PQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDY-DKDVSVYRSAASNFRVVQPDSFLDLMRLR 454
            |:.|..::||..:.....|.||.   .:|...:.| .:|..:..||.    ||.|...:.||.|:
  Rat   454 PRLLAKQSRQLVVSPLVSFGGDG---PISSVRLHYRPQDSMITWSAI----VVDPSENVTLMNLK 511

  Fly   455 -----SIRFDIVEDKLGAFGITSTSGIVFVKNPQVL---------EEAPETIYFLNVTW------ 499
                 ::|..:.....|..|....|.::....|:.|         .|.|:.   |.|:|
  Rat   512 PRTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGPDR---LRVSWSLPSVP 573

  Fly   500 -------------------------------------------IDQQRLSHVRVI-------NVH 514
                                                       :| .||.|..::       :||
  Rat   574 LSGDGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLD-VRLYHCTLLGPASPSAHVH 637

  Fly   515 L-VHGRPENTSCELKVKSRSQTCAQIKYQ---------SQCVRYCGLATGGGSCQW--------- 560
            | :.|.|  ....|:.::.|.:..::.:|         |:.:....:|.|.|..||
  Rat   638 LPLSGPP--APRHLRAQALSDSEIRLMWQHPEAPPGPISKYIVEIQVAGGSGDPQWMDVDKPEET 700

  Fly   561 ----RGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGI 621
                ||.|::   |||...|..|          ::.|...:...:.|..|
  Rat   701 STTVRGLNAS---TRYLFRVRAS----------VQGLGDWSNTVEETTLG--------------- 737

  Fly   622 YSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNV 686
                       ||..|.:|:.|            ...||            ..|...::|.|:..
  Rat   738 -----------NGLQSASPVQE------------SRVAE------------DGLDQQLVLAVVGS 767

  Fly   687 AGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPL 751
            ....|            |..:..||.|:..:|..|.||   .:.|.       :||.|:..::..
  Rat   768 VSATC------------LTILAALLALVCIRRSCLHRR---HTFTY-------QSGSGEETILQF 810

  Fly   752 QSGF-----RFESGDAKWEFP---REKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLK 808
            .||.     |.:.......:|   .|.:..:.::|||.||||::....: .||.  ...|:||||
  Rat   811 SSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKK-DGLK--MNAAIKMLK 872

  Fly   809 KGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECA 872
            :.::..::.....|.::|.::. |||:|.|||||.:.....:.||||.||:|..:||.||.:|
  Rat   873 EYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLE-- 935

  Fly   873 GVDFADGVE-----PVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGL 932
             .|.|...|     .::.:.:|.||.....||.||||.:.:||||||||||:.:....||:||||
  Rat   936 -TDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGL 999

  Fly   933 TRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNL 997
            :|.   ::.|:|::..|:||:|||.|||...|||:||||||||||.||:::||.:||.|:....|
  Rat  1000 SRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL 1061

  Fly   998 WSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSN 1062
            :..|..||||::|.||.:.||.::|.||.|.|..||.|..:|.:..::|.....|:::  :...|
  Rat  1062 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNM--SLFEN 1124

  Fly  1063 PLYCGDDS 1070
            ..|.|.|:
  Rat  1125 FTYAGIDA 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	118/284 (42%)
Tie1	NP_445997.1	ig	130..211	CDD:395002
		Furin-like	217..339	CDD:395614
		EGF_Lam	228..266	CDD:238012
		Ig	351..442	CDD:472250
		Ig strand B	369..373	CDD:409556
		Ig strand C	385..389	CDD:409556
		Ig strand E	410..414	CDD:409556
		Ig strand F	424..429	CDD:409556
		Ig strand G	437..440	CDD:409556
		fn3	450..530	CDD:394996	20/82 (24%)
		fn3	549..631	CDD:394996	9/85 (11%)
		FN3	643..735	CDD:238020	19/106 (18%)
		PTKc_Tie1	835..1131	CDD:270671	123/306 (40%)