Protein Alignment Ret and Tek

DIOPT Version :9

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001099207.1
• Gene: Tek / 89804
• RGDID: 620980
• Length: 1120
• Species: Rattus norvegicus
• Alignment Length: 622
• Identity: 168/622 - (27%)
• Similarity: 264/622 - (42%)
• Gaps: 180/622 - (28%)

  Fly   484 VLEEAPETIYFLNVT-------WIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKY 541
            :|...||.|...|:|       |......|...:|..:.|.|:.|:...::|:|:.:.|..|:|
  Rat   636 ILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLK- 699

  Fly   542 QSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHV----------CDPL--EELN 594
                    ||.                        ||:.|   ||          .:|.  :|:.
  Rat   700 --------GLE------------------------PETTY---HVDIFAENNIGSSNPAFSQEIR 729

  Fly   595 PMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEA 659
            .:..|:|.                             ..||.
  Rat   730 TLPAPKDL-----------------------------GGGKM----------------------- 742

  Fly   660 EPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRR 724
                               :|:.:|..||..|        ||..|.|:::|.    .:|..:|||
  Rat   743 -------------------LLIAILGSAGMTC--------ITVLLAFLIMLQ----LKRANVQRR 776

  Fly   725 LGKQSMTTSSKQALPESGG-----------GDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLG 778
            :.:.......:.|:..:.|           .|..:.|:     .:..|.|::         .|:|
  Rat   777 MAQAFQNVREEPAVQFNSGTLALNRKAKNNPDPTIYPV-----LDWNDIKFQ---------DVIG 827

  Fly   779 EGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACT 842
            ||.||||||. ..:..||.  ...|:|.:|:.::..::.....|.::|.::. |||:|.|||||.
  Rat   828 EGNFGQVLKA-RIKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACE 889

  Fly   843 SSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGV-----EPVNVKMVLTFAWQICKGMAYL 902
            ......|.||||.:|:|..:||.||.:|   .|.|..:     ..::.:.:|.||..:.:||.||
  Rat   890 HRGYLYLAIEYAPHGNLLDFLRKSRVLE---TDPAFAIANSTASTLSSQQLLHFAADVARGMDYL 951

  Fly   903 SELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTS 967
            |:.:.:||||||||:|:.:..|.||:||||:|.   .:.|:|::..|:||:|||.|||...|||:
  Rat   952 SQKQFIHRDLAARNILVGENYIAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTT 1013

  Fly   968 KSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGR 1032
            .|||||:|||.||:::||.:||.|:....|:..|..|||:::|.||.:.||.::|.||.::|..|
  Rat  1014 NSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYER 1078

  Fly  1033 PSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDD 1069
            |||..:.....::|.....|::  |.......|.|.|
  Rat  1079 PSFAQILVSLNRMLEERKTYVN--TTLYEKFTYAGID 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	113/284 (40%)
		TyrKc	771..1042	CDD:197581	112/276 (41%)
Tek	NP_001099207.1	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		fn3	445..518	CDD:278470
		fn3	542..625	CDD:278470
		FN3	638..730	CDD:238020	25/127 (20%)
		PTKc_Tie2	812..1114	CDD:133219	121/327 (37%)
		STYKc	820..1088	CDD:214568	113/285 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910