DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and MAP3K21

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_115811.2 Gene:MAP3K21 / 84451 HGNCID:29798 Length:1036 Species:Homo sapiens


Alignment Length:372 Identity:104/372 - (27%)
Similarity:159/372 - (42%) Gaps:98/372 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   721 LQRRLG----------KQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDT 775
            :|||||          :.:.:.:...:.|.|        |:...|             |:|:|..
Human    85 VQRRLGIFPANYVAPCRPAASPAPPPSRPSS--------PVHVAF-------------ERLELKE 128

  Fly   776 VLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLS---EFQLLQEVSHPNVIKL 837
            ::|.|.||||.:      |...| ..||||..::........|..|   |.:|...:.|||:|:|
Human   129 LIGAGGFGQVYR------ATWQG-QEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIEL 186

  Fly   838 LGACTSSEAPLLIIEYARYGSLRSYL--------------RLSRKIECAGVDFADGVEPVNVKMV 888
            .|.|.......|::|:||.|:|...|              |.:|:|            |.:|  :
Human   187 RGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRI------------PPHV--L 237

  Fly   889 LTFAWQICKGMAYLSE---LKLVHRDLAARNVLLAD--------GKICKISDFGLTRDVYEDDAY 942
            :.:|.||.:||.||.|   :.::||||.:.|:||.:        .|..||:||||.|:.:.    
Human   238 VNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR---- 298

  Fly   943 LKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGY-- 1005
            ..:........|||||.:...:::..||:||:|||.|||:| |..||.||      ..|...|  
Human   299 TTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGI------DGLAVAYGV 356

  Fly  1006 -----RMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLG 1047
                 .:..|..|.|....:::.||..:|:.||||..:..:...:.|
Human   357 AVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEG 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 94/313 (30%)
MAP3K21NP_115811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
SH3_MLK4 42..97 CDD:212991 5/11 (45%)
Protein Kinases, catalytic domain 129..401 CDD:473864 91/303 (30%)
Leucine-zipper 1 425..446
Leucine-zipper 2 460..481
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..954
Blue background indicates that the domain is not in the aligned region.

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