DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and ntrk3b

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_002662799.4 Gene:ntrk3b / 798577 ZFINID:ZDB-GENE-010126-4 Length:818 Species:Danio rerio


Alignment Length:805 Identity:184/805 - (22%)
Similarity:291/805 - (36%) Gaps:259/805 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   426 DKDVSVYRSAA------SNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQV 484
            |.|:.:|....      .|.|.:||.:|.....||.|       .|....:.|.|..:| ::.|:
Zfish    96 DVDMELYTGLQRLTIINCNLRQIQPRAFSRNPHLRYI-------NLSRNPLASLSWQLF-QHLQL 152

  Fly   485 LEEAPETIYF---LNVTWIDQQRLSHVRVINVHLVHGRPENTSCE---LKVKSRSQTCAQIKYQS 543
            :|...|.:.|   ..:.||...||.....::...::       |:   .|:..||.:.|....|.
Zfish   153 VELRLEGVVFDCGCKIRWIQLWRLRGEAGLHTQQLY-------CKDGASKISLRSMSIAHCDLQD 210

  Fly   544 QCVRYCGLAT--GGG---SCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCT 603
            ..|.:..|..  ||.   ||  .||         ||.|||..:.                     
Zfish   211 ISVAHSNLTVLEGGNVTLSC--NGS---------GSPVPEVDWA--------------------- 243

  Fly   604 PAGRIVGPHSSNENKRGIYSASG-------------------TCICE-----DNGKCSCAPLDEE 644
                :.|.||.|.::..:|..:.                   |||.|     :|.....:.|...
Zfish   244 ----VKGLHSINTHQSTVYLPNTHSINLTLVNVSRDDNGFVLTCISENVVGMNNVSLQLSVLFPP 304

  Fly   645 P--KMKKPRKR-------------------------------------------------KNETE 658
            .  |:.:|.:|                                                 :|.|.
Zfish   305 VILKLDEPERRHHTCIEFTVRGFPHPTLHWFYKGREILQSEYIRMEMDYYKDYLEGCLTFENPTH 369

  Fly   659 AE--------------------------PLL---GVRRGTPP-----NQPLQDPMLLGV-LNVAG 688
            .:                          |.:   |:...|||     .:| :|...:.: :.:||
Zfish   370 YDNGNYTLVATNSLGSVSKTVFGHFLDPPFMEDDGIMEYTPPPEDEGKRP-EDSFGMSIAVGLAG 433

  Fly   689 FECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRR-----------LGKQS------------M 730
            |    .|:|.::    :|||:        .|..:|.           .|::.            :
Zfish   434 F----GCVFLIV----IFVLI--------NKYSRRNKFGIKGPVAVISGEEDSASPLHHVNHGIV 482

  Fly   731 TTSSKQALPES---GGGDFALMPLQSGFRFESGDAK-----WEFPREKLQLDTVLGEGEFGQVLK 787
            |..|..|.|::   |.....::.....||......|     ....|..:.|...||||.||:|..
Zfish   483 TPCSLDAGPDAVVIGMSRIPVIENPQYFRHGHNCNKPTTYVQHIKRRDIVLKRELGEGAFGKVFL 547

  Fly   788 GFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQ----LLQEVSHPNVIKLLGACTSSEAPL 848
            .....::.......||||.||..:     :....:||    ||..:.|.:::|..|.|...:..:
Zfish   548 AECYNLSPTKDKMLVAVKTLKDPT-----LTARKDFQREAELLTNLQHEHIVKFYGVCVDGDPLI 607

  Fly   849 LIIEYARYGSLRSYLRLSRKIECAGVD---FADGVEP------VNVKMVLTFAWQICKGMAYLSE 904
            ::.||.::|.|..:||      ..|.|   ..|| :|      :.:..:|..|.||..||.|||.
Zfish   608 MVFEYMKHGDLNKFLR------AHGPDAMILVDG-QPMQSNGELGLSQMLHIATQIAAGMVYLSS 665

  Fly   905 LKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKS 969
            ...||||||.||.|:.:|.:.||.|||::||:|..|.|.......:|::||.|||:....::::|
Zfish   666 QHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSSDYYRVGGHTMLPIRWMPPESIMYRKFSTES 730

  Fly   970 DVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPS 1034
            |||||||:.||:.|.|..|:..::...:...:..|..:|||..|.:.||.::..||..||..|.:
Zfish   731 DVWSFGVIMWEIFTYGKQPWFHLSNNEVIECITQGRVLDRPRLCPKEVYDLMLGCWQREPQQRLN 795

  Fly  1035 FKFLASEFEKLLGNNAK----YIDL 1055
            .|    :.:|:|....|    |:|:
Zfish   796 IK----DIQKVLYALGKATPVYLDI 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 96/291 (33%)
ntrk3bXP_002662799.4 LRR_8 103..159 CDD:404697 14/63 (22%)
leucine-rich repeat 105..128 CDD:275378 5/22 (23%)
leucine-rich repeat 129..151 CDD:275378 7/29 (24%)
LRRCT_2 164..207 CDD:465313 9/49 (18%)
ig 213..298 CDD:395002 23/120 (19%)
Ig strand B 226..230 CDD:409405 0/3 (0%)
Ig strand C 239..249 CDD:409405 2/34 (6%)
Ig strand E 265..269 CDD:409405 0/3 (0%)
Ig strand F 279..285 CDD:409405 2/5 (40%)
Ig strand G 293..296 CDD:409405 1/2 (50%)
IgI_TrKABC_d5 303..395 CDD:409360 5/91 (5%)
Ig strand A 304..310 CDD:409360 1/5 (20%)
Ig strand A' 312..315 CDD:409360 1/2 (50%)
Ig strand B 318..326 CDD:409360 0/7 (0%)
Ig strand C 329..336 CDD:409360 0/6 (0%)
Ig strand C' 339..342 CDD:409360 0/2 (0%)
Ig strand D 347..353 CDD:409360 0/5 (0%)
Ig strand E 357..365 CDD:409360 0/7 (0%)
Ig strand F 373..381 CDD:409360 0/7 (0%)
Ig strand G 384..392 CDD:409360 0/7 (0%)
PTKc_TrkC 525..811 CDD:270676 98/301 (33%)

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