Protein Alignment Ret and Fgr

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_077059.2
• Gene: Fgr / 79113
• RGDID: 621319
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 541
• Identity: 157/541 - (29%)
• Similarity: 223/541 - (41%)
• Gaps: 143/541 - (26%)

  Fly   578 ESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLD 642
            |.||.|    ||.:..:....||..:||...||         .|.|.|||.:     ....|..|
  Rat    29 EERYYP----DPTQGRSSSISPQPISPAFLNVG---------NIRSVSGTGV-----TIFVALYD 75

  Fly   643 EEPK------MKKPRKRK--NET-----EAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRS 694
            .|.:      ..|..|..  |.|     ||..|...|.|..|:.        .|..|...:.: .
  Rat    76 YEARTGDDLTFTKGEKFHILNNTEYDWWEARSLSSGRTGYVPSN--------YVAPVDSIQAE-E 131

  Fly   695 CMFFVITCPLLFVLLLLCLLIAQRKMLQRRL-------G----KQSMTTSSKQALP----ESGGG 744
            ..|..|:                ||..:|:|       |    ::|.||....:|.    :...|
  Rat   132 WYFGKIS----------------RKDAERQLLSDGNPQGAFLIRESETTKGAYSLSIRDWDQNRG 180

  Fly   745 D----FALMPLQSG-------FRFES-------------------------------GDAK--WE 765
            |    :.:..|..|       .:|||                               |.||  ||
  Rat   181 DHIKHYKIRKLDMGGYYITTRAQFESVQDLVRHYMEVNDGLCYLLTAPCMVMKPQTLGLAKDAWE 245

  Fly   766 FPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS 830
            ..|..:.||..||.|.||.|..|...      ..|.||||.||.|:.|.:  |.|.|.|:::.:.
  Rat   246 IDRNSIALDRRLGTGCFGDVWLGTWN------CSTKVAVKTLKPGTMSPK--AFLEEAQIMKLLR 302

  Fly   831 HPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKM--VLTFA 892
            |..:::|....  ||.|:.|: |:..||||..:|: .||..             |:.:  ::..|
  Rat   303 HDKLVQLYAVV--SEEPIYIVTEFMCYGSLLDFLK-DRKGH-------------NLMLPNLVDMA 351

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .|:.:||||:..:..:||||.|.|:|:.:..||||:||||.| :..||.|..:...:.|:||.||
  Rat   352 AQVAEGMAYMERMNYIHRDLRAANILVGEHLICKIADFGLAR-LIVDDEYNPQQGTKFPIKWTAP 415

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            |:.....:|.||||||||:|..||||.|..||||:..:.:...::.||.|..|..|..::|.::.
  Rat   416 EAALFGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVME 480

  Fly  1023 TCWADEPNGRPSFKFLASEFE 1043
            ..|..:|..||:|::|.|..|
  Rat   481 QTWRLDPEERPTFEYLQSFLE 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/277 (36%)
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..46		6/20 (30%)
		SH3	68..125	CDD:473055	14/64 (22%)
		SH2_Src_Fgr	128..228	CDD:198230	18/116 (16%)
		Protein Kinases, catalytic domain	255..502	CDD:473864	99/272 (36%)