Protein Alignment Ret and ZAP70

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 104/311 - (33%)
• Similarity: 158/311 - (50%)
• Gaps: 38/311 - (12%)

  Fly   758 ESGDAKWEFPREKLQL-DTVLGEGEFGQVLKGF----ATEIAGLPGITTVAVKMLKKGSNSVEYM 817
            |..|.|....|:.|.: |..||.|.||.|.:|.    ..:|       .||:|:||:|:...:..
Human   412 ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQI-------DVAIKVLKQGTEKADTE 469

  Fly   818 ALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEP 882
            .::.|.|::.::.:|.:::|:|.| .:||.:|::|.|..|.|..:|...|             |.
Human   470 EMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR-------------EE 520

  Fly   883 VNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDA-YLKRS 946
            :.|..|.....|:..||.||.|...||||||||||||.:....|||||||::.:..||: |..||
Human   521 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 585

  Fly   947 RDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPE 1011
            ..:.|:||.|||.:....::|:|||||:||..||.::.|..||..:....:.:.::.|.||:.|.
Human   586 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 650

  Fly  1012 NCSEAVYSIVRTCWADEPNGRPSF-----------KFLASEFEKLLGNNAK 1051
            .|...:|:::..||..:...||.|           ..|||:.|...|:..|
Human   651 ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQK 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	99/295 (34%)
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191
		SH2_C-SH2_Zap70	240..343	CDD:198265
		PTKc_Zap-70	421..689	CDD:270686	95/288 (33%)