Protein Alignment Ret and YES1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_005424.1
• Gene: YES1 / 7525
• HGNCID: 12841
• Length: 543
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 108/287 - (37%)
• Similarity: 164/287 - (57%)
• Gaps: 26/287 - (9%)

  Fly   760 GDAK--WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822
            |.||  ||.|||.|:|:..||:|.||:|..|...      |.|.||:|.||.|:...|  |.|.|
Human   264 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN------GTTKVAIKTLKPGTMMPE--AFLQE 320

  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVK 886
            .|:::::.|..::.|....  ||.|:.|: |:...|||..:|:           ..|| :.:.:.
Human   321 AQIMKKLRHDKLVPLYAVV--SEEPIYIVTEFMSKGSLLDFLK-----------EGDG-KYLKLP 371

  Fly   887 MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951
            .::..|.||..||||:..:..:||||.|.|:|:.:..:|||:||||.| :.||:.|..|...:.|
Human   372 QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLAR-LIEDNEYTARQGAKFP 435

  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEA 1016
            :||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.||||..|:.|.|:
Human   436 IKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 500

  Fly  1017 VYSIVRTCWADEPNGRPSFKFLASEFE 1043
            ::.::..||..:|:.||:|:::.|..|
Human   501 LHELMNLCWKKDPDERPTFEYIQSFLE 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	100/275 (36%)
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45
		SH3_Yes	94..151	CDD:212940
		SH2_Src_family	154..253	CDD:199827
		PTKc_Yes	264..542	CDD:270654	108/287 (38%)