DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and TIE1

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens

Alignment Length:	438	Identity:	149/438 - (34%)
Similarity:	228/438 - (52%)	Gaps:	55/438 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 NETEAEPLLG--------VRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLL 711
            :.|..|..||        |:......:.|...::|.|:......|            |..:..||
Human   729 SNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATC------------LTILAALL 781

  Fly   712 CLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWE-----FP---R 768
            .|:..:|..|.||   ::.|.       :||.|:..::...||....:...|.:     :|   .
Human   782 TLVCIRRSCLHRR---RTFTY-------QSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEW 836

  Fly   769 EKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HP 832
            |.:..:.::|||.||||::....: .||.  ...|:||||:.::..::.....|.::|.::. ||
Human   837 EDITFEDLIGEGNFGQVIRAMIKK-DGLK--MNAAIKMLKEYASENDHRDFAGELEVLCKLGHHP 898

  Fly   833 NVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVE-----PVNVKMVLTFA 892
            |:|.|||||.:.....:.||||.||:|..:||.||.:|   .|.|...|     .::.:.:|.||
Human   899 NIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLE---TDPAFAREHGTASTLSSRQLLRFA 960

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .....||.||||.:.:||||||||||:.:....||:||||:|.   ::.|:|::..|:||:|||.
Human   961 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLPVRWMAI 1022

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            |||...|||:||||||||||.||:::||.:||.|:....|:..|..||||::|.||.:.||.::|
Human  1023 ESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMR 1087

  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDS 1070
            .||.|.|..||.|..:|.:..::|.....|:::  :...|..|.|.|:
Human  1088 QCWRDRPYERPPFAQIALQLGRMLEARKAYVNM--SLFENFTYAGIDA 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	118/284 (42%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	117/276 (42%)
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248
		ig	356..441	CDD:278476
		fn3	452..536	CDD:278470
		fn3	548..632	CDD:278470
		FN3	644..736	CDD:238020	2/6 (33%)
		PTKc_Tie1	836..1132	CDD:270671	123/306 (40%)
		TyrKc	839..1107	CDD:197581	117/276 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910