Protein Alignment Ret and TEC

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_047272062.1
• Gene: TEC / 7006
• HGNCID: 11719
• Length: 722
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 98/303 - (32%)
• Similarity: 157/303 - (51%)
• Gaps: 38/303 - (12%)

  Fly   750 PLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKG-FATEIAGLPGITTVAVKMLKKGSNS 813
            |..:||.:|    |||....:|.....||.|.||.|..| :..:.       .||:|.:::|:..
Human   444 PTTAGFSYE----KWEINPSELTFMRELGSGLFGVVRLGKWRAQY-------KVAIKAIREGAMC 497

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLR-----LSRKIECAG 873
            .|  ..:.|.:::.:::||.:::|.|.||..:...::.|:...|.|.::||     .||.:
Human   498 EE--DFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV---- 556

  Fly   874 VDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYE 938
                          :|:....:|:||.||.....:||||||||.|:::..:.|:||||:.|.|.
Human   557 --------------LLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVL- 606

  Fly   939 DDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKT 1003
            ||.|...|..:.||||..||......::|||||||||||.||:.|.|..|:.......:.:::..
Human   607 DDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTR 671

  Fly  1004 GYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL 1046
            |:|:.:|:..|..||.::..||.::|.|||||:.|....::|:
Human   672 GHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELV 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	91/283 (32%)
TEC	XP_047272062.1	PH_Btk	98..239	CDD:269944
		SH3_Tec	273..328	CDD:212838
		SH2_Tec_Itk	331..437	CDD:198259
		PTKc_Tec_Rlk	456..715	CDD:270685	91/287 (32%)