Protein Alignment Ret and SYK

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_003168.2
• Gene: SYK / 6850
• HGNCID: 11491
• Length: 635
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 115/337 - (34%)
• Similarity: 170/337 - (50%)
• Gaps: 40/337 - (11%)

  Fly   718 RKMLQRRLGKQSMTTSSKQALPE------SGGGDFALMPLQSGFRFESGDAKWE--------FPR 768
            ||....:..:|..|.|.....||      ..|.....:|:.:.. :||..|..|        ..|
Human   304 RKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEV-YESPYADPEEIRPKEVYLDR 367

  Fly   769 EKLQL-DTVLGEGEFGQVLKGF--ATEIAGLPGITTVAVKMLKKGSNSVEYM-ALLSEFQLLQEV 829
            :.|.| |..||.|.||.|.||:  ..::     :.|||||:||..:|..... .||:|..::|::
Human   368 KLLTLEDKELGSGNFGTVKKGYYQMKKV-----VKTVAVKILKNEANDPALKDELLAEANVMQQL 427

  Fly   830 SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQ 894
            .:|.:::::|.| .:|:.:|::|.|..|.|..||:.:|.              |..|.::....|
Human   428 DNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRH--------------VKDKNIIELVHQ 477

  Fly   895 ICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLK-RSRDRVPVKWMAPE 958
            :..||.||.|...||||||||||||......|||||||::.:..|:.|.| ::..:.||||.|||
Human   478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542

  Fly   959 SLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRT 1023
            .:..:.::|||||||||||.||..:.|..||.|:....:.::|:.|.||..|..|...:|.::..
Human   543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607

  Fly  1024 CWADEPNGRPSF 1035
            ||..:...||.|
Human   608 CWTYDVENRPGF 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/271 (37%)
SYK	NP_003168.2	SH2_N-SH2_Zap70_Syk_like	13..116	CDD:198191
		Interdomain A	108..167
		SH2_C-SH2_Syk_like	164..262	CDD:198264
		Interdomain B	260..370		14/66 (21%)
		PTKc_Syk	375..631	CDD:133247	98/265 (37%)