Protein Alignment Ret and SRC

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_047296363.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 562
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 112/295 - (37%)
• Similarity: 160/295 - (54%)
• Gaps: 42/295 - (14%)

  Fly   760 GDAK--WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822
            |.||  ||.|||.|:|:..||:|.||:|..|...      |.|.||:|.||.|:.|.|  |.|.|
Human   283 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKPGTMSPE--AFLQE 339

  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSL--------RSYLRLSRKIECAGVDFAD 878
            .|:::::.|..:::|....  ||.|:.|: ||...|||        ..||||.:.::.|.
Human   340 AQVMKKLRHEKLVQLYAVV--SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA----- 397

  Fly   879 GVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYL 943
                           ||..||||:..:..|||||.|.|:|:.:..:||::||||.| :.||:.|.
Human   398 ---------------QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYT 446

  Fly   944 KRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMD 1008
            .|...:.|:||.|||:.....:|.||||||||:|..||.|.|..||||:..:.:...::.||||.
Human   447 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 511

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            .|..|.|:::.::..||..||..||:|::|.:..|
Human   512 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/283 (37%)
SRC	XP_047296363.1	SH3_Src	114..169	CDD:212941
		SH2_Src_Src	173..273	CDD:198228
		PTKc_Src	286..562	CDD:270656	110/292 (38%)