DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and Kit

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_071600.1 Gene:Kit / 64030 RGDID:620568 Length:978 Species:Rattus norvegicus


Alignment Length:1118 Identity:265/1118 - (23%)
Similarity:415/1118 - (37%) Gaps:350/1118 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 LYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQP--- 131
            |:..|.|..|          :|.....|..|...|:....:..|         ..|:..|.|   
  Rat   124 LFGKEDNDAL----------VRCPLTDPQVSNYSLIECDGKSLP---------TDLKFVPNPKAG 169

  Fly   132 --LEEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAG 194
              ::........:|...:||     ..|.:.|.|.|      .|..|||....|.||:     ..
  Rat   170 ITIKNVKRAYHRLCIRCAAQ-----REGKWMRSDKF------TLKVRAAIKAIPVVSV-----PE 218

  Fly   195 SSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILD---IKLLDRN 256
            :|| :||:...:|                      :.||:|       ..|..:|   |||..:.
  Rat   219 TSH-LLKEGDTFT----------------------VICTIK-------DVSTSVDSMWIKLNPQP 253

  Fly   257 DNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAY 321
            .:..:::.:|          :.|.|..      |..::||..::..|    ||| |:|.  |:| 
  Rat   254 QSKAQVKRNS----------WHQGDFN------YERQETLTISSARV----NDS-GVFM--CYA- 294

  Fly   322 EADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHES 386
                                |..|.......:|:..:...::.....:.|..|....|:..:.|.
  Rat   295 --------------------NNTFGSANVTTTLKVVEKGFINIFPVKNTTVFVTDGENVDLVVEF 339

  Fly   387 EQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPT---VDYDKDVSVYRSAASNFRVVQPDSFL 448
            |     |.|....|..|:.:.            .||   .||.|.     ...||.|.|..   |
  Rat   340 E-----AYPKPEHQQWIYMNR------------TPTNRGEDYVKS-----DNQSNIRYVNE---L 379

  Fly   449 DLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINV 513
            .|.||:           |..|.|.|   ..|.|..|.......:|                    
  Rat   380 RLTRLK-----------GTEGGTYT---FLVSNSDVSASVTFDVY-------------------- 410

  Fly   514 HLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPE 578
              |:.:||..:.:..:..|.| |....:....:            .|.            .|...
  Rat   411 --VNTKPEILTYDRLMNGRLQ-CVAAGFPEPTI------------DWY------------FCTGA 448

  Fly   579 SRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDN---GKCSCAP 640
            .:.|    ..|:..::........:|.|::|...|.:.:   ::..:||..|:.:   ||.|.. 
  Rat   449 EQRC----TVPVPPVDVQIQNASVSPFGKLVVQSSIDSS---VFRHNGTVECKASNAVGKSSAF- 505

  Fly   641 LDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLL 705
                  .....|..::.:.:|           ..|..|:|:|               ||:|..|:
  Rat   506 ------FNFAFKGNSKEQIQP-----------HTLFTPLLIG---------------FVVTAGLM 538

  Fly   706 FVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALM-PLQSGFRFESGDAKWEFPRE 769
            .::    :::...|.||:     .|.....:.:.|..|.::..: |.|..:     |.||||||.
  Rat   539 GII----VMVLAYKYLQK-----PMYEVQWKVVEEINGNNYVYIDPTQLPY-----DHKWEFPRN 589

  Fly   770 KLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPN 833
            :|.....||.|.||:|::..|..:.......||||||||..::..|..||:||.::|..: :|.|
  Rat   590 RLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMN 654

  Fly   834 VIKLLGACTSSEAPLLIIEYARYGSLRSYLRL------------------------SRKIECAG- 873
            ::.||||||.....|:|.||..||.|.::||.                        |::..|.. 
  Rat   655 IVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQADAALYKNLLHSKESSCDSS 719

  Fly   874 ---VDFADGVEPV---------------------------------NVKMVLTFAWQICKGMAYL 902
               :|...||..|                                 :::.:|:|::|:.||||:|
  Rat   720 NEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFL 784

  Fly   903 SELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTS 967
            :....:||||||||:||..|:|.||.||||.||:..|..|:.:...|:|||||||||:.:.|||.
  Rat   785 ASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFNCVYTF 849

  Fly   968 KSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNG 1031
            :|||||:|:..|||.:||:|||||: .....:.::|.|:||..||:...|:|.:::|||..:|..
  Rat   850 ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAAMYEVMKTCWDADPLK 914

  Fly  1032 RPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCG---------DDSALITTELGEPESLQHLW 1087
            ||:||.:....||.:.:::|:|      .||...|.         |.|..:.:......|.|.|.
  Rat   915 RPTFKQVVQLIEKQISDSSKHI------YSNLANCNPNPENPVVVDHSVRVNSVGSSTSSTQPLL 973

  Fly  1088 SPPKIAYDIHDQA 1100
                    :|:.|
  Rat   974 --------VHEDA 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 122/341 (36%)
TyrKc 771..1042 CDD:197581 120/333 (36%)
KitNP_071600.1 ig 216..307 CDD:278476 29/169 (17%)
IG_like 220..309 CDD:214653 30/162 (19%)
Ig4_SCFR 313..413 CDD:143268 31/160 (19%)
Ig 428..503 CDD:299845 15/106 (14%)
PKc_like 555..929 CDD:304357 133/378 (35%)
Pkinase_Tyr 591..925 CDD:285015 120/333 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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