Protein Alignment Ret and BLK

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_011542126.1
• Gene: BLK / 640
• HGNCID: 1057
• Length: 531
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 106/310 - (34%)
• Similarity: 167/310 - (53%)
• Gaps: 28/310 - (9%)

  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            :||.||:.|:|...||.|:||:|..|:      ......||:|.||:|:.|.|  |.|.|..:::
Human   233 EWEIPRQSLRLVRKLGSGQFGEVWMGY------YKNNMKVAIKTLKEGTMSPE--AFLGEANVMK 289

  Fly   828 EVSHPNVIKLLGACTSSEAPLLII-EYARYGSL-----------RSYLRLSRKIECAG-VDF--A 877
            .:.|..:::|....|  :.|:.|: ||...|..           |:.|...|::.|.. :||  .
Human   290 ALQHERLVRLYAVVT--KEPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKT 352

  Fly   878 DGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAY 942
            |....:::..::..:.||.:||||:..:..:||||.|.|:|:::...|||:||||.|.:  |..|
Human   353 DEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII--DSEY 415

  Fly   943 LKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRM 1007
            ..:...:.|:||.|||::...|:|.|:||||||||..|::|.|..||||::...:...|:.||||
Human   416 TAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRM 480

  Fly  1008 DRPENCSEAVY-SIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLE 1056
            .||:.|...:| .::..||...|..||:|:||.|..|.......:..:|:
Human   481 PRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQ 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/294 (34%)
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942
		SH2_Src_Blk	120..219	CDD:198234
		Protein Kinases, catalytic domain	233..522	CDD:473864	105/300 (35%)