Protein Alignment Ret and ROS1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_011534351.1
• Gene: ROS1 / 6098
• HGNCID: 10261
• Length: 2357
• Species: Homo sapiens
• Alignment Length: 1427
• Identity: 314/1427 - (22%)
• Similarity: 500/1427 - (35%)
• Gaps: 505/1427 - (35%)

  Fly    14 IITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVL-----RMEDNRLASDYLYSL 73
            |:...|.|...:|   ....::|.|.:|..       .|.:|::.     :...|:...|:
Human  1061 ILPSGKCCNKNEV---VVEFRWNKPKHENG-------VLTKFEIFYNISNQSITNKTCEDW---- 1111

  Fly    74 EQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQPLEEYCSE 138
                 :.:|.:...:..:.:..||.....|.|.||....|......|...:.|:.|.|
Human  1112 -----IAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFP------- 1164

  Fly   139 LEHI-----------------CFW--------SSAQYTIAESHGPYRRKD--------------F 164
              |:                 ..|        |:..||.....|.|...|              .
Human  1165 --HLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSEL 1227

  Fly   165 FEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQAR 229
            |:..|:..:......::..|:           :|.||:::            ||:......|:.:
Human  1228 FQDSLVFDITVITIDWISRHL-----------YFALKESQ------------NGMQVFDVDLEHK 1269

  Fly   230 ITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFY--LEQPYFQADEEAGKKVIYVD 292
            :            |:.|  ::|:.:||       .:...|..|  |.:.|:......|.::.|
Human  1270 V------------KYPR--EVKIHNRN-------STIISFSVYPLLSRLYWTEVSNFGYQMFY-- 1311

  Fly   293 KDTLEANAHLVYAVHNDS-HGLFRPDCHAYEADHTGRPHTIVSCQL-RFSRNGVFR------ETP 349
                       |::.:.: |.:.:|     .|.:........||.: .|..:|...      |.|
Human  1312 -----------YSIISHTLHRILQP-----TATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKP 1360

  Fly   350 YCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSA 414
            .....:|:::.      ||......|:.:         ..:|..|                   |
Human  1361 LIYFAKAQEIW------AMDLEGCQCWRV---------ITVPAML-------------------A 1391

  Fly   415 GRSLSPPTVDYD--------KD-VSVYRSAASNFRVVQ--------------------PD-SFLD 449
            |::|...|||.|        || ..:|::...|..:|.                    || :||.
Human  1392 GKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLS 1456

  Fly   450 LM-------------RLRSIRFDIVEDKLGAFGITSTSGIVFV--------KNPQVLE----EAP 489
            |.             ...:||..:.:..|..:||||.:....|        ||...|:    |..
Human  1457 LASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQ 1521

  Fly   490 ETIYFLNVTWIDQQRLS----HVRVINV------HL-----VHGRPENTSCE----LKVKSRSQT 535
            ::|..:.    |.|..|    .:.|.|.      ||     :.|:.:|...|    :....||.|
Human  1522 DSIALIE----DLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDT 1582

  Fly   536 CAQIKYQ--------SQCVRY----CGLA------------------------TGGG-------S 557
            ...|.::        .:.|||    ..||                        :||.       :
Human  1583 SLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLA 1647

  Fly   558 C----QWRGSNS----AMFGT--RYGSCVPES-------------------------RY------ 581
            |    .|...:.    .||.|  :..|.|||:                         :|
Human  1648 CHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHV 1712

  Fly   582 ---C---PDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNEN----------KRGIYSASGTCIC 630
               |   |.:||: :..|.|..     :...|:|..:.:.||          |.|:.:..|.
Human  1713 KTSCSQGPAYVCN-ITNLQPYT-----SYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGI--- 1768

  Fly   631 EDNGKCSCAPLDEEPKMKKPRKRKNETE-AEP--------LLGVRRGTPPNQPLQDPMLLGVLNV 686
                          ||:.:..|...:.| ||.        :|.:|:.|..|  ||:..|...:..
Human  1769 --------------PKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNN--LQNQNLRWKMTF 1817

  Fly   687 AGFECDRSC------------------------------------------------------MF 697
            .| .|...|                                                      :|
Human  1818 NG-SCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIF 1881

  Fly   698 FVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTT--SSKQALPESGG---------GDFALMPL 751
            .|:|.||.||.        .|::..::..|:.:|.  :..:.|.|..|         ..:|:..|
Human  1882 LVVTIPLTFVW--------HRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTL 1938

  Fly   752 QSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGL-PGITTVAVKMLKKGSNSVE 815
            .:....|:..|   ||||||.|..:||.|.||:|.:|.|.:|.|: .|...||||.|||||...|
Human  1939 PTQEEIENLPA---FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE 2000

  Fly   816 YMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAG-----VD 875
            .:..|.|..|:.:.:|||::|.||.|..:|...:|:|....|.|.:|||.:|.....|     ||
Human  2001 KIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVD 2065

  Fly   876 FADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLA-----DGKICKISDFGLTRD 935
            ..|            ....|.||..||..:..:||||||||.|::     ..:|.||.||||.||
Human  2066 LVD------------LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2118

  Fly   936 VYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSL 1000
            :|::|.|.||....:||:|||||||.|.::|::|||||||:|.||::|||..|||..:..::.:.
Human  2119 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNY 2183

  Fly  1001 LKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGN---NAKY---IDLETNA 1059
            ::||.|::.|.||.:.:::::..|||.||:.||:|..:..:.: |..|   |:.|   .:...:.
Human  2184 VQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ-LFRNFFLNSIYKSRDEANNSG 2247

  Fly  1060 VSNPLYCGDDSALITTELGE--PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPG 1119
            |.|..:.|:|..:|.....:  |.:|....:...:.|.:  .||...|.||:    |..|.|
Human  2248 VINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMV--LATECGQGEEK----SEGPLG 2303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	118/292 (40%)
ROS1	XP_011534351.1	FN3	<103..>297	CDD:442628
		FN3	211..290	CDD:238020
		FN3	567..677	CDD:238020
		FN3	1051..1157	CDD:238020	20/114 (18%)
		FN3	1441..1867	CDD:442628	78/455 (17%)
		FN3	1669..1758	CDD:238020	15/94 (16%)
		FN3	1763..1852	CDD:238020	17/108 (16%)
		PTKc_c-ros	1960..2226	CDD:270640	113/277 (41%)