| Sequence 1: | NP_477044.1 | Gene: | Ret / 43875 | FlyBaseID: | FBgn0011829 | Length: | 1235 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_066124.1 | Gene: | RET / 5979 | HGNCID: | 9967 | Length: | 1114 | Species: | Homo sapiens |
| Alignment Length: | 1277 | Identity: | 384/1277 - (30%) |
|---|---|---|---|
| Similarity: | 553/1277 - (43%) | Gaps: | 300/1277 - (23%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 6 IVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNRLAS--- 67
Fly 68 -DYLYS-----LEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLE 126
Fly 127 VTPQPLEE---------------------YCSELE--HICFWSSAQYTIAESHGPYRRKDFFEPV 168
Fly 169 LIGALNSRAAKYLCPHVSLEYSLNAGSS-HFVLKQNRL--YTRQTLDHDELNGLNAKAGQLQARI 230
Fly 231 TCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYV-DKD 294
Fly 295 TLEANAHLVYAVHNDSHGLFRPDCHA---YEADHTGRPHTIVSCQLRFSRNGVF-RETPYCVSLE 355
Fly 356 A-RDLTI-----------VSRVDAMSATANV-CYHINLSKLHESEQELPQALPL----RARQHR- 402
Fly 403 -----IFESEEFNG-------DSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRS 455
Fly 456 IRFDIVEDKLGAFGITSTSGIVFVKNPQVLE--EAPETIYFLNVTWIDQQRLSHVRVINVHLVHG 518
Fly 519 R--PENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRY 581
Fly 582 CPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCIC-EDNGKCSCAPLDEEP 645
Fly 646 KMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLL 710
Fly 711 LCLL----------------IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMP-LQSGFRFE 758
Fly 759 SGDA-------KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEY 816
Fly 817 MALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKI-----------E 870
Fly 871 CAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRD 935
Fly 936 VYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSL 1000
Fly 1001 LKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLY 1065
Fly 1066 CGDDSALITTELGE------PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPR 1124
Fly 1125 PLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPA 1166 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Ret | NP_477044.1 | PKc_like | 770..1049 | CDD:304357 | 157/289 (54%) |
| TyrKc | 771..1042 | CDD:197581 | 155/281 (55%) | ||
| RET | NP_066124.1 | Cadherin | 172..261 | CDD:278457 | 20/96 (21%) |
| PTKc_RET | 723..1012 | CDD:173631 | 157/289 (54%) | ||
| Pkinase_Tyr | 724..1005 | CDD:285015 | 155/281 (55%) | ||
| Inhibitors binding | 805..807 | 1/1 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165147061 | |
| Domainoid | 1 | 1.000 | 317 | 1.000 | Domainoid score | I1263 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 415 | 1.000 | Inparanoid score | I1843 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D153428at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0008389 | |
| OrthoInspector | 1 | 1.000 | - | - | oto88447 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_108073 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24416 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4355 |
| SonicParanoid | 1 | 1.000 | - | - | X6379 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 11.930 | |||||