Protein Alignment Ret and ntrk2b

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001184090.3
• Gene: ntrk2b / 570240
• ZFINID: ZDB-GENE-010126-2
• Length: 799
• Species: Danio rerio
• Alignment Length: 1077
• Identity: 221/1077 - (20%)
• Similarity: 341/1077 - (31%)
• Gaps: 399/1077 - (37%)

  Fly    52 LAQFQVLRMEDNRLASDYLYSLEQNPLLRINSSSGEIYMRTDYRS---PNSSATFLVT-AFPRDQ 112
            :..|.||..|.:......:|...|..|..||....:.|  ::.|:   .|:..|::.| ||..:.
Zfish    47 IEDFPVLMPESDMENITDIYISNQKRLFTINEDHMKFY--SNLRNLTVTNTHLTYVSTMAFFNNS 109

  Fly   113 P-------DHELLNVSHLSLE--------VTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRK 162
            .       |:.|..:|.:::.        ::..||:..|..:     |.......:|       :
Zfish   110 KLQYLNLRDNNLSTLSWMAMRNSNVSTLLLSGNPLQCACENI-----WIKLWLDDSE-------R 162

  Fly   163 DFFEPVLIGA---LNSRAAKYLCPHVSLE-----YSLNAGSSHFVLKQNRLYTRQTLDHDELNGL 219
            |..:.:..|.   ..||....||.|..:|     .|..|||...|:                  .
Zfish   163 DVLQCLQEGGKAKTLSRLTLPLCEHPRVEVFPTDVSQMAGSDATVI------------------C 209

  Fly   220 NAKAGQLQARITCTVKLSSR---------DQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQ 275
            || :|.....:|.|:..|..         .:.....:|.:..|..||||.||
Zfish   210 NA-SGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPNDNGRKL------------- 260

  Fly   276 PYFQADEEAGKKVIYVDKDTLEANAHL----------VYAVHNDSH--------GLFRPDCHAYE 322
             ...|:...|:         :||...|          :|.......        |..|||.|.|
Zfish   261 -ICSAENIVGQ---------IEATVMLNISFPPTVLELYLPERSQDWCIPFVVTGNPRPDLHWY- 314

  Fly   323 ADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESE 387
              |.|:|               ..|..| :..|..|:|            |..||..|
Zfish   315 --HEGKP---------------LEEQEY-IRTEIHDIT------------NTEYHGCL------- 342

  Fly   388 QELPQALPLRARQHRIFESEEF---NGDSAGRSLSPPTVDYD--KDVSVYRSAASNFRVVQPDSF 447
             :|.....:....:.:..|.||   .|:.....:..|.||:.  :.|..|.:      .|.||
Zfish   343 -KLDTPTHIHNGIYTLVASNEFGEDRGNVTAHFMRIPDVDHSGIEGVFYYDT------TVSPD-- 398

  Fly   448 LDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVIN 512
                      ...:||::..:.:...:|:..
Zfish   399 ----------IPPLEDRVAVYIVVGIAGVAL---------------------------------- 419

  Fly   513 VHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVP 577
                      |.|.|.:       ..:||                     ..|:.||.:..|.|.
Zfish   420 ----------TGCILML-------VFLKY---------------------GRSSKFGMKGSSSVI 446

  Fly   578 ESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLD 642
            .:   .|....||.                    |.||.|
Zfish   447 SN---DDDSASPLH--------------------HVSNGN------------------------- 463

  Fly   643 EEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPL-QDPMLLGVLNVAGFECDRSCMFFVITCPLLF 706
                                     .||.:..: .|.:::|:..:.           ||..|..|
Zfish   464 -------------------------NTPSSSEMGPDAVIIGMTKIP-----------VIENPQYF 492

  Fly   707 VLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKL 771
                                                        ...|...:|........|..:
Zfish   493 --------------------------------------------RNPGSMLKSDTLVQHIKRHNI 513

  Fly   772 QLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNS--VEYMALLSEFQLLQEVSHPNV 834
            .|...||||.||:|.......::.......||||.||:.|.|  .::.   .|.:||..:.|.::
Zfish   514 LLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKEASESGRADFH---REAELLTNLQHEHI 575

  Fly   835 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVD---FADGVEPVNVKM----VLTFA 892
            :|..|.|..|:..:::.||.::|.|..:||      ..|.|   .|||.:.:.|::    :|..|
Zfish   576 VKFYGVCVESDPLIMVFEYMKHGDLNKFLR------AHGPDAVLMADGQQSLLVELTQPQMLHIA 634

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||..||.||:....||||||.||.|:.:..:.||.|||::||||..|.|.......:|::||.|
Zfish   635 QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPP 699

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            ||:....:|::|||||.||:.||:.|.|..|:..::...:...:..|..:.||..|.:.||.::.
Zfish   700 ESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLML 764

  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAK----YIDL 1055
            .||..||..|.:.|    |...||.:.||    |:|:
Zfish   765 GCWQREPYMRLNIK----EIHNLLQSLAKASPVYLDI 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	98/287 (34%)
ntrk2b	NP_001184090.3	None