DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ret and LOC569566

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_698054.5	Gene:	LOC569566 / 569566	-ID:	-	Length:	509	Species:	Danio rerio

Alignment Length:	295	Identity:	68/295 - (23%)
Similarity:	108/295 - (36%)	Gaps:	96/295 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 QRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFES-----GDAKWE----------F 766
            |.|.::|::.....:.:.|......|..:..|..|::|..|.|     |...||          .
Zfish   140 QPKKMRRKVHVALASKTVKFQCQAEGNPNPKLRWLKNGKEFNSDQRTGGYTLWENTWAIVMESVV 204

  Fly   767 PREKLQLDTVLGEGEFGQVLKGFATEI-----------AGLPGITTVAVKMLKKGSNSVEYMA-L 819
            |.:|... |.|.|.|:|.:...:..::           ||||...|..|     ||: ||::. :
Zfish   205 PSDKGNY-TCLVENEYGSINHTYQLDVWESSPERPILYAGLPANRTAMV-----GSD-VEFVCKV 262

  Fly   820 LSEFQ-LLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPV 883
            :::.| .:|.:.|   |::.|   |.|.|                              ||:..|
Zfish   263 INDSQSYIQWIKH---IRVNG---SQEGP------------------------------DGIPYV 291

  Fly   884 NVKMVLTFAWQICKGMAYLS----ELKLVHRDLAARNVLLAD-GKICKISDFGLTRDVYEDDAYL 943
            .|..           ||.||    |:::|   |..|||.|.| |:...:.|..:  .:....|:|
Zfish   292 RVLK-----------MADLSTTDKEIEVV---LQLRNVSLEDAGQYTCLVDNSI--GISHKSAWL 340

  Fly   944 KRSRDRVPVKWMAPESLADH--VYTSKSD--VWSF 974
            ...:|..||.....:|:..|  |.|::.|  .|.|
Zfish   341 TVVKDAEPVSVKEGDSVTLHTGVKTNQQDDVKWYF 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	54/227 (24%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	53/226 (23%)
LOC569566	XP_698054.5	Ig	36..121	CDD:299845
		I-set	139..230	CDD:254352	20/90 (22%)
		Ig	146..230	CDD:299845	18/84 (21%)
		IG_like	245..342	CDD:214653	35/154 (23%)
		Ig	253..342	CDD:299845	32/141 (23%)
		IG_like	347..442	CDD:214653	9/29 (31%)
		Ig	354..441	CDD:299845	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910