Protein Alignment Ret and csk

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001071067.1
• Gene: csk / 556454
• ZFINID: ZDB-GENE-061103-493
• Length: 450
• Species: Danio rerio
• Alignment Length: 341
• Identity: 110/341 - (32%)
• Similarity: 176/341 - (51%)
• Gaps: 60/341 - (17%)

  Fly   711 LCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDT 775
            ||..:.:.|:::.       |.:::.....||                     |...|::|:|..
Zfish   163 LCTRLIKPKIMEG-------TVAAQDEFSRSG---------------------WALNRKELKLIQ 199

  Fly   776 VLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGA 840
            .:|:||||.|:.|   :..|    ..||||.:|..:.:   .|.::|..::.::.|.|:::|||.
Zfish   200 TIGKGEFGDVMVG---DYRG----KKVAVKCIKHDATA---QAFVAEASVMTQLRHNNLVQLLGV 254

  Fly   841 CTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSE 904
            ....:..|.|: ||...|||..||| ||.....|.|           .::.|:..:||.|.||..
Zfish   255 IVEEKGSLYIVTEYMAKGSLVDYLR-SRGRTVIGGD-----------RLINFSMDVCKAMEYLEA 307

  Fly   905 LKLVHRDLAARNVLLADGKICKISDFGLTRDV--YEDDAYLKRSRDRVPVKWMAPESLADHVYTS 967
            ...|||||||||||:::..|.|:||||||::.  .:|.|       ::||||.:||:|.:..:::
Zfish   308 NNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTA-------KLPVKWTSPEALREKKFST 365

  Fly   968 KSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGR 1032
            ||||||:|:|.||:.:.|..|||.|..:.:...::.||:||.|:.|...||.|::.||..:...|
Zfish   366 KSDVWSYGILLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVR 430

  Fly  1033 PSFKFLASEFEKLLGN 1048
            |||:.|..:.:.::.|
Zfish   431 PSFRDLREKLQDIITN 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	102/282 (36%)
csk	NP_001071067.1	SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	3/11 (27%)
		PTKc_Csk	188..443	CDD:133213	103/283 (36%)