DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and kdr

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001019824.2 Gene:kdr / 554230 ZFINID:ZDB-GENE-041001-112 Length:1357 Species:Danio rerio


Alignment Length:1374 Identity:309/1374 - (22%)
Similarity:512/1374 - (37%) Gaps:442/1374 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 DVYFPTTSVKFNMP----INEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLEQNPLL--RINS 83
            ||.|.....:..:|    :.:.:.::::|.|:.:...    |.:   :.::...:..:|  |:.|
Zfish   139 DVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELST----DGK---EVIWDSRRGFILPSRVVS 196

  Fly    84 SSGEIYMRTDYRSPN-SSATFLVTAFPRD------QPDHELLNV-SHLSLEVTPQPLEEYCSELE 140
            .:|.:|.:|..|:.. .|:.::|......      .|.||.|.| ..|.|..|.........:.:
Zfish   197 YAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHTERNVGIDFQ 261

  Fly   141 HICFW-------------SSAQYTIAESHGPYRRKDFFEPVLIG--------ALNSRAAKYLCPH 184
                |             |:::|..:.:     :|..:..:.:.        .||. ..:|:|..
Zfish   262 ----WTFPHEKRSVNGSMSTSRYKTSSN-----KKKLWNSLELSNTLTVENVTLND-TGEYICTA 316

  Fly   185 VS------LEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITC--------TVK 235
            .|      .:.||......|:...::|:  ||::        ||||..:|:|..        .|:
Zfish   317 SSGQMQKIAQASLIVYEKPFIALSDQLW--QTVE--------AKAGDAEAKILVKYYAYPEPAVR 371

  Fly   236 LSSRDQ---------RKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGK-KVIY 290
            ....||         .||.|.:.:.:                        |...:::||. .|:.
Zfish   372 WYKNDQLIVLRDGYRMKFYRGVHLTI------------------------YGVTEKDAGNYTVVM 412

  Fly   291 VDKDTLEANAHLVYAVHNDSHGLFRP------DCHAYEADHT--------GRPHTI-------VS 334
            .:|.|.|........|.||...:|..      |.|.|.:..|        ..|.||       ..
Zfish   413 TNKITKEEQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTGSGGSSPVTIKWQWMPRED 477

  Fly   335 CQLRF---------------------SRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYH- 377
            |.:||                     .:|.:..:|    |::.|.|..:|.:....|..:..|. 
Zfish   478 CPVRFLPKSDPSMAKCDKWREMSNNTGKNPLISQT----SVDERTLKTISTLKIQKAVDHALYRC 538

  Fly   378 INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVV 442
            |..:|:.:.::.:            :|:...|...|...|.||..   .:||             
Zfish   539 IATNKMGQDQRVI------------VFQVTRFLNLSVLPSSSPIE---GQDV------------- 575

  Fly   443 QPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTW-------- 499
                   :||       .|.|:|                          :|: |:.|        
Zfish   576 -------IMR-------CVADRL--------------------------LYY-NLRWYRVANVAN 599

  Fly   500 ---------IDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGG 555
                     .|...|||:...||.:...:..|.:.::.:.:.:.                :..|.
Zfish   600 HDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATM----------------MDQGL 648

  Fly   556 GSCQWRGSNSAMFGTRYGSCV--------PESRYCPDHVCDP---LEELNPMACPQDCTPAGRIV 609
            .:||     ..:.||...:|:        .|......::.|.   :.:...:.|....||...||
Zfish   649 YACQ-----VEIVGTNEKTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIV 708

  Fly   610 GPHSSNENKRGIYSASGTCI-------------CEDNGKCSCAPLDEEPKMKKPRKRKNETEAEP 661
            .    .::.:.:...||..:             .||:|...|...::: ..:....|.:...||.
Zfish   709 W----TKDNQTVMEGSGVILKRSNRVLTIQRVKKEDSGLYICTACNQQ-GCESSEARISVDGAEE 768

  Fly   662 LLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLG 726
            .:.|....|          :|.:.:|                 :|:.||:..:|..||    |..
Zfish   769 KMNVELIMP----------IGAVVIA-----------------MFLWLLIVFVIRNRK----RPN 802

  Fly   727 KQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDA-KWEFPREKLQLDTVLGEGEFGQVLKGFA 790
            ...:.|.....:.:|..     ||:.......:.|| ||||||::|:|...||.|.||||::..|
Zfish   803 DGDLKTGYLSIILDSDD-----MPMDEHCERLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATA 862

  Fly   791 TEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-IIEY 853
            ..|......|||||||||:|:.|.||.||:||.::|..:.|. ||:.||||||....||: |:||
Zfish   863 YGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEY 927

  Fly   854 ARYGSLRSYLRLSR------------------------------------KIE-CAGV------- 874
            .::|:|.|||:..|                                    ::: |.|.       
Zfish   928 CKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTG 992

  Fly   875 -----------DFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKIS 928
                       :.:|. :.:.::.::::::|:.|||.:|:..|.:||||||||:||::..:.||.
Zfish   993 EQTSTTLQDEQESSDW-DHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKIC 1056

  Fly   929 DFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIA 993
            ||||.||||:|..|:::...|:|:||||||::.|.|||::|||||||||.||:.:||||||||:.
Zfish  1057 DFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVC 1121

  Fly   994 -PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-----Y 1052
             .::....||.|.||..|:..:..:|..:..||.|.|..||:|..|......||..:|:     |
Zfish  1122 IDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDY 1186

  Fly  1053 IDLETNAVSNPLYCGD-DSALITTEL----------GEPESLQHLWSPPKIAYDIHDQATSYDQS 1106
            |         ||..|: :..|:...|          |..|:..|..:.|.:.:.  .|..|    
Zfish  1187 I---------PLTNGEMEEELVAPHLNVTSKRSFYAGNTEAQLHYGNAPPLGFP--QQINS---- 1236

  Fly  1107 EEEMPVTSTAPPGY-DLP---RPLLD-------ATANGQVLRYENDLRFPLNI-------RKSSC 1153
             ..:||..|   |: |:|   ..::|       ..:..|:...:...:.|||.       .|.|.
Zfish  1237 -SGVPVNMT---GFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESL 1297

  Fly  1154 TPSYSNMTS 1162
            ....||.||
Zfish  1298 ASESSNQTS 1306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 128/336 (38%)
TyrKc 771..1042 CDD:197581 126/328 (38%)
kdrNP_001019824.2 Ig_2 143..221 CDD:290606 13/84 (15%)
IG_like 233..331 CDD:214653 19/107 (18%)
Ig 241..335 CDD:299845 14/103 (14%)
IG_like 345..429 CDD:214653 21/115 (18%)
Ig2_VEGFR-2 356..429 CDD:143272 15/96 (16%)
IG 571..654 CDD:214652 20/160 (13%)
Ig 571..654 CDD:299845 20/160 (13%)
I-set 677..763 CDD:254352 13/90 (14%)
IGc2 691..753 CDD:197706 11/66 (17%)
PKc_like 835..1178 CDD:304357 134/343 (39%)
Pkinase_Tyr 843..1171 CDD:285015 126/328 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..975 0/30 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1357 5/11 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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