DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and kdr

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001019824.2 Gene:kdr / 554230 ZFINID:ZDB-GENE-041001-112 Length:1357 Species:Danio rerio


Alignment Length:1374 Identity:309/1374 - (22%)
Similarity:512/1374 - (37%) Gaps:442/1374 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 DVYFPTTSVKFNMP----INEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLEQNPLL--RINS 83
            ||.|.....:..:|    :.:.:.::::|.|:.:...    |.:   :.::...:..:|  |:.|
Zfish   139 DVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELST----DGK---EVIWDSRRGFILPSRVVS 196

  Fly    84 SSGEIYMRTDYRSPN-SSATFLVTAFPRD------QPDHELLNV-SHLSLEVTPQPLEEYCSELE 140
            .:|.:|.:|..|:.. .|:.::|......      .|.||.|.| ..|.|..|.........:.:
Zfish   197 YAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHTERNVGIDFQ 261

  Fly   141 HICFW-------------SSAQYTIAESHGPYRRKDFFEPVLIG--------ALNSRAAKYLCPH 184
                |             |:::|..:.:     :|..:..:.:.        .||. ..:|:|..
Zfish   262 ----WTFPHEKRSVNGSMSTSRYKTSSN-----KKKLWNSLELSNTLTVENVTLND-TGEYICTA 316

  Fly   185 VS------LEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITC--------TVK 235
            .|      .:.||......|:...::|:  ||::        ||||..:|:|..        .|:
Zfish   317 SSGQMQKIAQASLIVYEKPFIALSDQLW--QTVE--------AKAGDAEAKILVKYYAYPEPAVR 371

  Fly   236 LSSRDQ---------RKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGK-KVIY 290
            ....||         .||.|.:.:.:                        |...:::||. .|:.
Zfish   372 WYKNDQLIVLRDGYRMKFYRGVHLTI------------------------YGVTEKDAGNYTVVM 412

  Fly   291 VDKDTLEANAHLVYAVHNDSHGLFRP------DCHAYEADHT--------GRPHTI-------VS 334
            .:|.|.|........|.||...:|..      |.|.|.:..|        ..|.||       ..
Zfish   413 TNKITKEEQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTGSGGSSPVTIKWQWMPRED 477

  Fly   335 CQLRF---------------------SRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYH- 377
            |.:||                     .:|.:..:|    |::.|.|..:|.:....|..:..|. 
Zfish   478 CPVRFLPKSDPSMAKCDKWREMSNNTGKNPLISQT----SVDERTLKTISTLKIQKAVDHALYRC 538

  Fly   378 INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVV 442
            |..:|:.:.::.:            :|:...|...|...|.||..   .:||             
Zfish   539 IATNKMGQDQRVI------------VFQVTRFLNLSVLPSSSPIE---GQDV------------- 575

  Fly   443 QPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTW-------- 499
                   :||       .|.|:|                          :|: |:.|        
Zfish   576 -------IMR-------CVADRL--------------------------LYY-NLRWYRVANVAN 599

  Fly   500 ---------IDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGG 555
                     .|...|||:...||.:...:..|.:.::.:.:.:.                :..|.
Zfish   600 HDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATM----------------MDQGL 648

  Fly   556 GSCQWRGSNSAMFGTRYGSCV--------PESRYCPDHVCDP---LEELNPMACPQDCTPAGRIV 609
            .:||     ..:.||...:|:        .|......::.|.   :.:...:.|....||...||
Zfish   649 YACQ-----VEIVGTNEKTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIV 708

  Fly   610 GPHSSNENKRGIYSASGTCI-------------CEDNGKCSCAPLDEEPKMKKPRKRKNETEAEP 661
            .    .::.:.:...||..:             .||:|...|...::: ..:....|.:...||.
Zfish   709 W----TKDNQTVMEGSGVILKRSNRVLTIQRVKKEDSGLYICTACNQQ-GCESSEARISVDGAEE 768

  Fly   662 LLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLG 726
            .:.|....|          :|.:.:|                 :|:.||:..:|..||    |..
Zfish   769 KMNVELIMP----------IGAVVIA-----------------MFLWLLIVFVIRNRK----RPN 802

  Fly   727 KQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDA-KWEFPREKLQLDTVLGEGEFGQVLKGFA 790
            ...:.|.....:.:|..     ||:.......:.|| ||||||::|:|...||.|.||||::..|
Zfish   803 DGDLKTGYLSIILDSDD-----MPMDEHCERLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATA 862

  Fly   791 TEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-IIEY 853
            ..|......|||||||||:|:.|.||.||:||.::|..:.|. ||:.||||||....||: |:||
Zfish   863 YGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEY 927

  Fly   854 ARYGSLRSYLRLSR------------------------------------KIE-CAGV------- 874
            .::|:|.|||:..|                                    ::: |.|.       
Zfish   928 CKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTG 992

  Fly   875 -----------DFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKIS 928
                       :.:|. :.:.::.::::::|:.|||.:|:..|.:||||||||:||::..:.||.
Zfish   993 EQTSTTLQDEQESSDW-DHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKIC 1056

  Fly   929 DFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIA 993
            ||||.||||:|..|:::...|:|:||||||::.|.|||::|||||||||.||:.:||||||||:.
Zfish  1057 DFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVC 1121

  Fly   994 -PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-----Y 1052
             .::....||.|.||..|:..:..:|..:..||.|.|..||:|..|......||..:|:     |
Zfish  1122 IDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDY 1186

  Fly  1053 IDLETNAVSNPLYCGD-DSALITTEL----------GEPESLQHLWSPPKIAYDIHDQATSYDQS 1106
            |         ||..|: :..|:...|          |..|:..|..:.|.:.:.  .|..|    
Zfish  1187 I---------PLTNGEMEEELVAPHLNVTSKRSFYAGNTEAQLHYGNAPPLGFP--QQINS---- 1236

  Fly  1107 EEEMPVTSTAPPGY-DLP---RPLLD-------ATANGQVLRYENDLRFPLNI-------RKSSC 1153
             ..:||..|   |: |:|   ..::|       ..:..|:...:...:.|||.       .|.|.
Zfish  1237 -SGVPVNMT---GFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESL 1297

  Fly  1154 TPSYSNMTS 1162
            ....||.||
Zfish  1298 ASESSNQTS 1306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 128/336 (38%)
kdrNP_001019824.2 Ig 227..333 CDD:472250 19/115 (17%)
Ig strand B 244..248 CDD:409448 2/3 (67%)
Ig strand C 259..263 CDD:409448 0/7 (0%)
Ig strand E 297..301 CDD:409448 0/3 (0%)
Ig strand F 311..316 CDD:409448 2/4 (50%)
Ig strand G 324..327 CDD:409448 0/2 (0%)
Ig 336..429 CDD:472250 23/126 (18%)
Ig strand B 356..360 CDD:409353 2/3 (67%)
Ig strand C 369..373 CDD:409353 1/3 (33%)
Ig strand E 393..397 CDD:409353 0/3 (0%)
Ig strand F 407..412 CDD:409353 1/4 (25%)
Ig strand G 422..425 CDD:409353 0/2 (0%)
IG_like 571..654 CDD:214653 20/160 (13%)
I-set 677..763 CDD:400151 13/90 (14%)
Ig strand B 694..697 CDD:409353 0/2 (0%)
Ig strand C 706..710 CDD:409353 2/7 (29%)
Ig strand E 729..733 CDD:409353 0/3 (0%)
Ig strand F 743..748 CDD:409353 1/4 (25%)
VEGFR-2_TMD 768..802 CDD:375470 11/64 (17%)
Protein Kinases, catalytic domain 835..1178 CDD:473864 134/343 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..975 0/30 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1357 5/11 (45%)

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