DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and flt1

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001014829.3 Gene:flt1 / 544667 ZFINID:ZDB-GENE-050407-1 Length:1272 Species:Danio rerio


Alignment Length:1438 Identity:334/1438 - (23%)
Similarity:538/1438 - (37%) Gaps:469/1438 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 STTIVFVTLLTIITQRKH-----C-----------AAVDVYFPTTSVKFNMPINEESESIFSKIP 51
            |:.::.||...::.:|..     |           :.|...:|.|.: .|....::|....|::.
Zfish    28 SSPVLDVTEKQLVIERNQTLQLSCRGRWELQWVLPSGVPKLYPDTHI-VNTQCGKKSNQYCSRLT 91

  Fly    52 LAQFQV---------LRMEDNRLASDYLYSLE-QNPLLRINSSSGE-IYMRT------DYRSPNS 99
            |:....         .|.::.:..|.|:|..: |.|.:::.|...: :||:.      ..|..|.
Zfish    92 LSPALTQHTGSYRCRYRQKERKQTSVYIYITDSQRPFVKVQSEIPDVVYMKEGEPLVFPCRVTNP 156

  Fly   100 SATFLVTAFP--RDQPDHELLNVSHLSLEVTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRK 162
            .|...:..||  |..|||.  |:                       .|:|.|..|      .|..
Zfish   157 DAKVSLVKFPLHRITPDHR--NI-----------------------IWNSRQGFI------IRSP 190

  Fly   163 DFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELN---------- 217
            .||   .||..:..                      .:.....||.:.|.|..:|          
Zfish   191 TFF---YIGLFSCE----------------------TIVDGVKYTNKFLTHRPVNKILDVYLNST 230

  Fly   218 GL-NAKAGQLQARITCTV--------------------------KLS-SRDQRKFSRILDIKLLD 254
            || :...|::.| :.|||                          ::| ||....|..:|.|..|.
Zfish   231 GLVHTLQGEMLA-LNCTVTAEWNSRVSISWTYPQKANGSAIISKRISRSRSNMLFYSVLTIPSLS 294

  Fly   255 RND---------NGPKLQESSSKFDFYLEQPYFQADEE--------AGKK--------------- 287
            :.|         :||..:|:::....| :||:.:....        ||:|               
Zfish   295 KADKGLYKCQVTSGPSKRETNTTVIVY-DQPFIRLKHRNGPVVQAFAGQKSFRLTPKLKAFPAPE 358

  Fly   288 VIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCV 352
            :|:: ||.:.| |......|.|...|...|.    |:.....:||::   ...:.|:|       
Zfish   359 IIWL-KDGMVA-AERCSRYHVDGFSLVIRDV----AEEDAGIYTILT---GIQQYGLF------- 407

  Fly   353 SLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQ--HRIFESEEFNGDSAG 415
                ::|||       :...||...|. .|...|:|  |..:...:||  |           ...
Zfish   408 ----QNLTI-------TLVVNVKPQIG-EKSVSSQQ--PGTVQRGSRQALH-----------CTS 447

  Fly   416 RSLSPPTVDY-----------DKDVSVYRSAASNFRVVQPDSFLDLMRLR-------------SI 456
            ..:.||.:.:           :|               .|.|....:|.:             |.
Zfish   448 HGVPPPQIQWLWHPCPPKGLCEK---------------PPPSSWTAVRKKTGVTSTHNPILTISH 497

  Fly   457 RFDIVEDKLGAFGITS-----TSGIVFVKNPQVL--EEAPETIYFLNV------TWIDQQR---- 504
            |.:::|.|....|:.:     .|||.......:|  :|.....|..:|      :.:::.|    
Zfish   498 RQEVLEGKNKTVGVLTVGEALVSGIYRCVTSNILGRDELDIPFYVTDVKEGLVASLVEEPREGGD 562

  Fly   505 LSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFG 569
            |..:.:.|.||...           .|.|:..:||....:.....|..|.|     :.|::..||
Zfish   563 LRLLCIANRHLYSD-----------LSWSRITSQITVWDEASGLDGELTEG-----QFSHTLHFG 611

  Fly   570 TRYGSCVPESRY-CP-------DHV-CDPLEELNPMACP------QDCT-----------PAGRI 608
            .:..:......| |.       :|: .|...|:..:..|      .|.|           ||..:
Zfish   612 LKNLTARDSGTYRCSATHLLTGEHIHLDTAVEVTVLQAPVLLGNLSDHTVNVSNSITLHCPARGV 676

  Fly   609 VGPHSS-NENKRGIYSASGTCI-------------CEDNGKCSCAPLDEEPKMKKPRKRKNETEA 659
            ..||.: .:|:|.:...||..:             .||.|..:|          :...::...|:
Zfish   677 PQPHITWYKNQRKLQQVSGIMLFPEEGTLHIDRITVEDQGFYTC----------QATNQRGSVES 731

  Fly   660 EPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRR 724
            ...:.|:..: .:..|:.|.|             :|...|.|   ||.|||..|:   ||:..  
Zfish   732 SAYIWVQNSS-ESLSLEIPTL-------------ACTCVVAT---LFWLLLTLLI---RKLKH-- 774

  Fly   725 LGKQSMTTSSKQALPESGGGDFALMPL----------QSGFRFESGDAKWEFPREKLQLDTVLGE 779
                          |.|..|....:|:          :...|.:...|||||||::|:|:..||.
Zfish   775 --------------PNSDNGKAEYLPIILHPGEEPLVEHCDRLQYDPAKWEFPRDRLKLEKPLGR 825

  Fly   780 GEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTS 843
            |.||:|::..|..|......|||||||||.|:...|:.||::|.::|..:.|. ||:.||||||.
Zfish   826 GAFGRVMQASAVGIGNSASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHHINVVNLLGACTK 890

  Fly   844 SEAPLL-IIEYARYGSLRSYLRLSRKI----------------ECAG------------------ 873
            |..||: |:||.::|:|.:||:..|::                .|.|                  
Zfish   891 SGGPLMVIVEYCQFGNLSAYLKSKREVFLLNRVNKEEEGVMKEGCKGRLTSVSSRQSNASSGFSE 955

  Fly   874 ----VDFADG------VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKIS 928
                :...|.      .:|:.::.::::::|:.:||.:|:..|.:||||||||:||::..:.||.
Zfish   956 ERGEISEEDSDCLSELSDPLLLEDLISYSFQVARGMEFLASRKCIHRDLAARNILLSNNNVVKIC 1020

  Fly   929 DFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI- 992
            ||||.||:|:|..|::....|:|:|||||||:.|.|:|::|||||:|||.||:.:||||||||: 
Zfish  1021 DFGLARDLYKDPDYVRNGDARLPLKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLN 1085

  Fly   993 APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL-----GNNAKY 1052
            ..:.....||.|.||..|:..:..:|||:..||.:.|..||||..|......||     .:...|
Zfish  1086 MDEEFCRRLKHGTRMCSPQYSTPEIYSIMCACWENNPEDRPSFTTLVEILGDLLQTCVQQDGKDY 1150

  Fly  1053 IDLETNAVSNPLYCGDDSALITTELGEPESLQHLW------SPPKIAYDIHDQATSYDQSEEEMP 1111
            |.|  ||     :...:...|||.|.:.:..|...      ||.||     ...::::...:|:|
Zfish  1151 IPL--NA-----FKSGEGHTITTHLNQRDISQKALGNSSYISPGKI-----KAMSTFEDLHKEIP 1203

  Fly  1112 VTSTAPPGYDLPRPLLDATANGQVLRYENDLRFPL-NIRK----------SSCTPSYSNMTSEPP 1165
            ....:..|..||        :.::::.:...||.. ||.|          .|..|..|:.|:.||
Zfish  1204 DDEQSDSGMVLP--------SEELIQVKWTDRFKTKNITKFFSRGQSQPRLSSAPCCSDQTALPP 1260

  Fly  1166 ATTSLPHY 1173
                 |||
Zfish  1261 -----PHY 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 124/330 (38%)
flt1NP_001014829.3 Ig 224..322 CDD:472250 19/99 (19%)
Ig strand B 241..245 CDD:409353 1/4 (25%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 0/4 (0%)
Ig strand G 313..316 CDD:409353 1/2 (50%)
IgI_VEGFR-1 325..416 CDD:409499 20/117 (17%)
Ig strand A 325..329 CDD:409499 0/3 (0%)
Ig strand A' 335..340 CDD:409499 0/4 (0%)
Ig strand B 345..353 CDD:409499 0/7 (0%)
Ig strand C 357..363 CDD:409499 1/6 (17%)
Ig strand C' 365..368 CDD:409499 0/2 (0%)
Ig strand D 374..378 CDD:409499 1/3 (33%)
Ig strand E 380..385 CDD:409499 1/4 (25%)
Ig strand F 393..402 CDD:409499 2/11 (18%)
Ig strand G 405..416 CDD:409499 5/28 (18%)
Ig_3 419..529 CDD:464046 22/138 (16%)
IG_like 558..646 CDD:214653 20/103 (19%)
Ig strand B 563..567 CDD:409353 1/3 (33%)
Ig strand C 576..580 CDD:409353 1/14 (7%)
Ig strand E 606..612 CDD:409353 1/5 (20%)
Ig strand F 622..627 CDD:409353 2/4 (50%)
I-set 650..733 CDD:400151 16/92 (17%)
Ig strand B 667..671 CDD:409353 0/3 (0%)
Ig strand C 680..684 CDD:409353 1/3 (33%)
Ig strand E 703..707 CDD:409353 0/3 (0%)
Ig strand F 717..722 CDD:409353 1/14 (7%)
Ig strand G 730..733 CDD:409353 1/2 (50%)
PTKc_VEGFR 809..1138 CDD:270647 128/328 (39%)

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