DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Flt1

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_062179.2	Gene:	Flt1 / 54251	RGDID:	2621	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	197/704 - (27%)
Similarity:	295/704 - (41%)	Gaps:	208/704 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 GRIVGPHSS-------NENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLL 663
            |.|:||.:|       .|...|:|....|                        .:|...|:...|
  Rat   706 GIILGPGNSTLFIERVTEEDEGVYRCRAT------------------------NQKGVVESSAYL 746

  Fly   664 GVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQ 728
            .| :||.....|:                    ...:||..:...|...||....:.|:|...:.
  Rat   747 TV-QGTSDKSNLE--------------------LITLTCTCVAATLFWLLLTLFIRKLKRSSSEV 790

  Fly   729 SMTTSSKQALPESGGGDFALMPL-QSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATE 792
            .....|....|:.       :|| :...|.....:||||.||:|:|...||.|.||:|::..|..
  Rat   791 KTDYLSIIMDPDE-------VPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFG 848

  Fly   793 IAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-IIEYAR 855
            |...|...||||||||:|:.:.||.||::|.::|..:.|. ||:.||||||....||: |:||.:
  Rat   849 IKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 913

  Fly   856 YGSLRSYLRLSRKIECAGVDFADGVEPVNVKM--------------------------------- 887
            ||:|.:||:..|...|...|.|..:||...|:
  Rat   914 YGNLSNYLKSKRDFFCLNKDAALHMEPKKEKLEPDLEQDQKPRLDSVSSSESFTSSGFQEDKSVS 978

  Fly   888 --------------------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGL 932
                                ::::::|:.:||.:||..|.:||||||||:||::..:.||.||||
  Rat   979 DVEGGEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGL 1043

  Fly   933 TRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQN 996
            .||:|::..|::|...|:|:|||||||:.|.||::||||||:|||.||:.:||.|||||: ..::
  Rat  1044 ARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDED 1108

  Fly   997 LWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL--------------- 1046
            ..|.||.|.||..||..:..:|.|:..||..:|..||.|..|..:...||
  Rat  1109 FCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKLGDLLQANVQQDGKDYIPLN 1173

  Fly  1047 ----------------------------------GNNAKYI---------------DLETNAVSN 1062
                                              .::.:|:               :|..||.|.
  Rat  1174 AILTRNSGFTYSVPTFSEDFFKDGFTDPKFHSGSSDDVRYVNAFKFMSLERIKTFEELSPNATSM 1238

  Fly  1063 -PLYCGDDSALITTELGEPESLQHLW--SPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPR 1124
             ..|..|.|:|:|:    |...:..|  :.||.:..|..:.||   ..:|..::       |||.
  Rat  1239 FEDYHLDTSSLLTS----PLLKRFTWTETKPKASMKIDLRITS---KSKEAGLS-------DLPG 1289

  Fly  1125 PLLDATANGQV--LRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVP 1176
            |....::.|.:  :|.|::....|. ::|.|:|        ||...|:..||.|
  Rat  1290 PSFCFSSCGHIRPVRQEDEDDPELG-KESCCSP--------PPDYNSVVLYSSP 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	128/383 (33%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	126/326 (39%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653
		IG_like	237..328	CDD:214653
		Ig	245..327	CDD:299845
		Ig	353..424	CDD:299845
		IG_like	439..552	CDD:214653
		Ig	451..549	CDD:143165
		IG	568..640	CDD:214652
		IGc2	569..640	CDD:197706
		I-set	661..748	CDD:254352	12/65 (18%)
		IGc2	676..738	CDD:197706	9/55 (16%)
		PKc_like	819..1157	CDD:304357	132/337 (39%)
		Pkinase_Tyr	827..1154	CDD:285015	126/326 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910